Zobrazeno 1 - 10
of 22
pro vyhledávání: '"O Yu, Abakumova"'
Autor:
G. Yu. Lomakina, S. S. Aleksandrova, O. V. Podobed, D. V. Grishin, N. S. Melik-Nubarov, I. D. Grozdova, O. Yu. Abakumova, M. V. Pokrovskaya, Nikolay N. Sokolov, V. S. Pokrovski
Publikováno v:
Applied Biochemistry and Microbiology. 53:165-172
N-hydroxysuccinimide ester of monomethoxy polyethylene glycol hemisuccinate was synthesized. It acylated amino groups in a molecule of recombinant L-asparaginase from Erwinia carotovora. A method of L-asparaginase modification by the obtained activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d8924a54c80efd41db628e81f9a5c42
https://doi.org/10.1134/s0003683817020119
https://doi.org/10.1134/s0003683817020119
Publikováno v:
Moscow University Chemistry Bulletin. 71:122-126
The ChitoPEGylation method, which is a novel approach to regulating the catalytic properties of enzymes that is based on the formation of a covalent conjugate of an enzyme with branched copolymers of chitosan, has been developed. The efficiency of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::155c5ac5bc2dfe1e3bfc99df01c1bb92
https://doi.org/10.3103/s0027131416020073
https://doi.org/10.3103/s0027131416020073
Autor:
N S, Melik-Nubarov, I D, Grozdova, G Yu, Lomakina, M V, Pokrovskaya, V S, Pokrovski, S S, Aleksandrova, O Yu, Abakumova, O V, Podobed, D V, Grishin, N N, Sokolov
Publikováno v:
Prikladnaia biokhimiia i mikrobiologiia. 53(2)
N-hydroxysuccinimide ester of monomethoxy polyethylene glycol hemisuccinate was synthesized. It acylated amino groups in a molecule of recombinant L-asparaginase from Erwinia carotovora. A method of L-asparaginase modification by the obtained activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::443b609dfcfdad27ee24fb572d2aee01
https://pubmed.ncbi.nlm.nih.gov/29508977
https://pubmed.ncbi.nlm.nih.gov/29508977
Autor:
O. V. Podobed, Alexander I. Archakov, M. V. Pokrovskaya, N. S. Melik-Nubarov, Michael A. Eldarov, S. S. Aleksandrova, Nikolay N. Sokolov, Elena V. Kudryashova, D. V. Grishin, O. Yu. Abakumova
Publikováno v:
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 9:325-338
For more than 40 years L-asparaginases are used in combined therapy of acute lymphoblastic leukemia in children and the range of tumors sensitive to these enzymes constantly extends. This review summarizes results of studies aimed at creation of new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b85e089aeea31667105176253c15366
https://doi.org/10.1134/s199075081504006x
https://doi.org/10.1134/s199075081504006x
Autor:
D. V. Grishin, S. S. Aleksandrova, O. V. Podobed, O. Yu. Abakumova, M. V. Pokrovskaya, Alexander V. Veselovsky, A. A. Mishin, Vadim S. Pokrovsky, Nikolay N. Sokolov, D. D. Zhdanov
Publikováno v:
Molecular Biotechnology. 57:251-264
Site-directed mutagenesis of Rhodospirillum rubrum L-asparaginase (RrA) was performed in order to identify sites of the protein molecule important for its therapeutic and physico-chemical properties. Ten multipoint mutant genes were obtained, and fiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ca17995b90c94ab136e77873538f87
https://doi.org/10.1007/s12033-014-9819-0
https://doi.org/10.1007/s12033-014-9819-0
Publikováno v:
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 6:307-316
The dose- and time-dependent antitumor and cytotoxic effects of L-asparaginases from Erwinia carotovora (ECAR LANS) and Escherichia coli (MEDAC) have been investigated using human leukemic cells and human and animal solid tumor cells. These included
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dff8c0702ea3189764dcc4a8d15aa7e6
https://doi.org/10.1134/s1990750812040026
https://doi.org/10.1134/s1990750812040026
Autor:
Alexei Medvedev, Vivette Glover, O. Yu. Abakumova, Merton Sandler, O. V. Podobed, Tsvetkova Ta
Publikováno v:
Life Sciences. 69:1783-1790
We have previously demonstrated that isatin (indole-2,3 dione), an endogenous compound widely distributed in mammalian tissues and body fluids, effectively inhibits atrial natriuretic peptide (ANP) receptor binding and ANP-stimulated guanylyl cvclase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4902416e19d86c2286d10253049f7e76
https://doi.org/10.1016/s0024-3205(01)01270-x
https://doi.org/10.1016/s0024-3205(01)01270-x
Publikováno v:
Biomeditsinskaia khimiia. 59(3)
Cytotoxic and antitumor activity of the biligand vanadyl derivative of L-malic acid (bis(L-malato)oxovanadium(IV) (VO(mal) ) was investigated in comparison with inorganic vanadium(IV) compound - vanadyl sulfate (VOSO ) and also with oxovanadium monoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf9420fbaca28fdb9393e742a8ac86b
https://pubmed.ncbi.nlm.nih.gov/23987068
https://pubmed.ncbi.nlm.nih.gov/23987068
Publikováno v:
Bulletin of Experimental Biology and Medicine. 121:249-252
Using the method of ATP luminometry it is shown that crude membrane preparations from human and rat hepatocytes accumulate ATP 20–100 nmol/mg protein during a 1-min incubation under conditions of oxidative phosphorylation. Application of appropriat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10947b4d4febcc93f527e56f388358af
https://doi.org/10.1007/bf02446760
https://doi.org/10.1007/bf02446760
Autor:
A. Yu. Chevokin, L. V. Platonova, O. Yu. Abakumova, G. R. Sakevarashvili, Tsvetkova Ta, L. I. Kondakova, N. I. Shono, E. I. Gal'perin
Publikováno v:
Bulletin of Experimental Biology and Medicine. 127:47-49
The relationship between energy metabolism in the remaining liver tissue after 60% hepatectomy and the activity of low-molecular-weight thermostable hepatocyte growth factor was studied in rats. The energy status of the liver was markedly reduced 6 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ace2cdc069ae8bba9f03f03f57303e23
https://doi.org/10.1007/bf02432798
https://doi.org/10.1007/bf02432798