Psychological distress and trauma in doctors providing frontline care during the COVID-19 pandemic in the United Kingdom and Ireland: a prospective longitudinal survey cohort study

Autor: Daniel Horner, Jo Daniels, Charles Reynard, James Foley, Blair Graham, Mark David Lyttle, M Anderson, J Browning, M Clark, S Foster, S Hartshorn, M Jacobs, S Messahel, N Mullen, J Brown, Michael Barrett, S Subramaniam, S Williams, A Ahmed, E Williams, S Hall, Edward Carlton, C Bi, M Khan, R Hannah, S Taylor, L Dunlop, J Gumley, K Knight, C Williams, J Turner, B Taylor, R Mills, M Lim, J Evans, C O’Connell, Tom Roberts, A Rai, P Singh, M Williams, S Graham, Etimbuk Umana, R Taylor, S Rahman, J Wright, J Lynch, S Lewis, P Fitzpatrick, J Ng, V Talwar, N Ali, G Pells, P Ellis, J Bailey, John Cronin, J Morgan, K Samuel, A Ali, M Patel, R Evans, S Morgan, A Hill, S Rao, S Currie, C Thomas, K Thomas, William Hulme, Katie Samuel, Robert Hirst, H Cooper, L McKechnie, S Pradhan, A Brookes, W Niven, L Kane, C Rimmer, K Kaur, R Stewart, T Hussan, P Cuthbert, M Alex, F Barham, R Macfarlane, M Jee Poh Hock, C Ward, C Weegenaar, O Williams, S Manou, MH Elwan, C Nunn, C Reynard, L How, D McConnell, J Muller, H Malik, K Challen, C Magee, S Pintus, S Langston, C Szekeres, L Kehler, C Leech, Y Moulds, A Mackay, R Wright, A Saunders, S Naeem, N Cherian, C Boulind, L Brown, E Grocholski, A Tabner, M Colmar, D Raffo, L Somerset, C Holmes, L Armstrong, S Collins, J Lowe, J Ritchie, F Wood, M Mohammad, S Wilson, R O'Sullivan, R Ellis, M MacKenzie, B Johnson, R Das, L Robinson, P Turton, L Robertson, A Robertson, J Hunt, João Vinagre, H Millar, R Freeman, A Corfield, R McQuillan, A Hormis, L Mackenzie, S Sharma Hajela, J Phizacklea, J Maney, K Malik, D Metcalfe, N Mathai, S Timmis, A Sattout, R Newport, E Fadden, D Bawden, B O'Hare, C Roe, D Bewick, F Taylor, L Barnicott, A Charlton, L McCrae, C Munday, E Godden, A Turner, R Sainsbury, A Lawrence-Ball, R House, S Patil, I Skene, M Winstanley, N Tambe, D Mawhinney, M Elkanzi, T Perry, W Kan, M Cheema, A Clarey, R Greenhalgh, A Gulati, S Marimuthu, K Webster, A Howson, R Doonan, B Shrestha, L Stanley, A Trimble, E Colley, J Lockwood, T Mohamed, H Jarman, S Ramraj, V Worsnop, N Masood, R McLatchie, A Peasley, S Bongale, U Bait, S Nagendran, A Hay, F Mendes, H Raybould, T Baron, C Ponmani, M Depante, R Sneep, Z Al-Janabi, A Rainey, N Marriage, B Mallon, J McLaren, S Hart, M Elsheikh, L Cocker, S Keers, K L Vincent, D Craver, N Sarja, N Moultrie, M Viegas, S Purvis, E Wooffinden, C Davies, S Foreman, A Da-Costa, C Ngua, S Duckitt, N Hoskins, J Fryer, T Hine, F Ihsan, L Frost, H Abdullah, K Bader, K Gray, M Manoharan, R Muswell, P Amiri, M Bonsano, S Shrivastava, F Raza, E Christmas, M Riyat, L O'Rourke, H Knott, K Adeboye, M Ramazany, K Iftikhar, N Abela, R Darke, D Maasdorp, H Murphy, H Edmundson, c Orjioke, L Harwood, D Worley, K Lines, W Collier, J Everson, D Ranasinghe, N Maleki, A Stafford, S Gokani, M Charalambos, A Olajide, H Ahmad, K Holzman, A Patton, S Gilmartin, S Uí Bhroin, S Kukaswadia, C Prendergast, C Dalla Vecchia, M Grummell, I Grossi, B MacManus, A Boyle, A Waite, J Vinagre, D George, C Battle, J Anandarajah, I Hancock, D Manthalapo, Ramesh Babu, FM Burton, I Musliam, Veettil Asif, M JeePoh Hock

Publikováno v: BMJ Open, Vol 11, Iss 7 (2021)

Objectives The psychological impact of the COVID-19 pandemic on doctors is a significant concern. Due to the emergence of multiple pandemic waves, longitudinal data on the impact of COVID-19 are vital to ensure an adequate psychological care response

Externí odkaz: https://doaj.org/article/8bb128d7ad9a43de9f2244ace53ef9c0

Deterministic Multistage Constellation Reconfiguration Using Integer Programming and Sequential Decision-Making Methods

Autor: Lee, Hang Woon, Rogers, David O. Williams, Pearl, Brycen D., Chen, Hao, Ho, Koki

In this paper, we address the problem of reconfiguring Earth observation satellite constellation systems through multiple stages. The Multi-stage Constellation Reconfiguration Problem (MCRP) aims to maximize the total observation rewards obtained by

Externí odkaz: http://arxiv.org/abs/2401.11567

Mutation of the galectin‐3 glycan‐binding domain (Lgals3‐R200S) enhances cortical bone expansion in male mice and trabecular bone mass in female mice

Autor: Kevin A. Maupin, Cassandra R. Diegel, Payton D. Stevens, Daniel Dick, VAI Vivarium and Transgenic Core, Bart O. Williams

Publikováno v: FEBS Open Bio, Vol 12, Iss 10, Pp 1717-1728 (2022)

We previously observed that genomic loss of galectin‐3 (Gal‐3; encoded by Lgals3) in mice has a significant protective effect on age‐related bone loss. Gal‐3 has both intracellular and extracellular functionality, and we wanted to assess whet

Externí odkaz: https://doaj.org/article/874c659405224149baacd2786c3095d3

Modulation of immune cell function, IDO expression and kynurenine production by the quorum sensor 2-heptyl-3-hydroxy-4-quinolone (PQS)

Autor: Joy Ogbechi, Yi-Shu Huang, Felix I. L. Clanchy, Eirini Pantazi, Louise M. Topping, L. Gail Darlington, Richard O. Williams, Trevor W. Stone

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Many invasive micro-organisms produce ‘quorum sensor’ molecules which regulate colony expansion and may modulate host immune responses. We have examined the ability of Pseudomonas Quorum Sensor (PQS) to influence cytokine expression under conditi

Externí odkaz: https://doaj.org/article/0a21a9ffbdb34293be6dd44fbdbdf370

Standardization of Antigen-Emulsion Preparations for the Induction of Autoimmune Disease Models

Autor: Louise M. Topping, Laura Romero-Castillo, Vilma Urbonaviciute, Hans Bolinsson, Felix I. Clanchy, Rikard Holmdahl, B. Thomas Bäckström, Richard O. Williams

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Autoimmune murine disease models are vital tools for identifying novel targets and finding better treatments for human diseases. Complete Freund’s adjuvant is commonly used to induce disease in autoimmune models, and the quality of the adjuvant/aut

Externí odkaz: https://doaj.org/article/b164c77abfec4f66a5c07ab3578ba63a