Inhibition of nitric oxide production is associated with enhanced weight loss, decreased survival, and impaired alloengraftment in mice undergoing graft-versus-host disease after bone marrow transplantation

Autor: W R, Drobyski, C A, Keever, G A, Hanson, T, McAuliffe, O W, Griffith

Publikováno v: Blood. 84:2363-2373

The pathophysiologic role of nitric oxide (NO) in graft-versus-host disease (GVHD) was investigated in a murine bone marrow (BM) transplantation model where donor and recipient were H-2-matched but differed at multiple minor histocompatibility antige

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ea37258885a2463c4647c0385de8d4
https://doi.org/10.1182/blood.v84.7.2363.bloodjournal8472363

Evolutionary Analysis of the Mammalian IL-17 Cytokine Family Suggests Conserved Roles in Female Fertility.

Autor: Giangrazi F; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Buffa D; Department of Biology, Maynooth University, Maynooth, Ireland., Lloyd AT; Department of Science and Health, Institute of Technology, Carlow, Ireland., Redmond AK; School of Medicine, University College Dublin, Dublin 4, Ireland., Glover LE; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; Department of Reproductive Medicine, Merrion Fertility Clinic, Dublin 2, Ireland., O'Farrelly C; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; School of Medicine, Trinity College Dublin, Dublin, Ireland.

Publikováno v: American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2024 Aug; Vol. 92 (2), pp. e13907.

L-arginine binding to nitric-oxide synthase. The role of H-bonds to the nonreactive guanidinium nitrogens

Autor: B R, Babu, C, Frey, O W, Griffith

Publikováno v: The Journal of biological chemistry. 274(36)

Nitric-oxide synthase (NOS) catalyzes the oxidation of L-arginine to nitric oxide and L-citrulline. Because overproduction of nitric oxide causes tissue damage in neurological, inflammatory, and autoimmune disorders, design of NOS inhibitors has rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cdef7c46811f81e3e56e73f981ca2f01
https://pubmed.ncbi.nlm.nih.gov/10464242

N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase

Autor: B R, Babu, O W, Griffith

Publikováno v: The Journal of biological chemistry. 273(15)

Nitric oxide synthase (NOS) catalyzes the NADPH- and O2-dependent conversion of L-arginine to nitric oxide (NO) and citrulline; three isoforms, the neuronal (nNOS), endothelial, and inducible, have been identified. Because overproduction of NO is kno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::24330e0816da8a658ca5569bd7b9e84b
https://pubmed.ncbi.nlm.nih.gov/9535869

S-alkyl-L-thiocitrullines. Potent stereoselective inhibitors of nitric oxide synthase with strong pressor activity in vivo

Autor: K, Narayanan, L, Spack, K, McMillan, R G, Kilbourn, M A, Hayward, B S, Masters, O W, Griffith

Publikováno v: The Journal of biological chemistry. 270(19)

Nitric oxide synthase catalyzes the oxidation of a guanidino nitrogen of L-arginine to nitric oxide with concomitant formation of citrulline. Enzyme activity is inhibited by a variety of N omega-monosubstituted L-arginine analogs including N omega-al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::66696df5bf4032ebd1389bbd25284a28
https://pubmed.ncbi.nlm.nih.gov/7538112