Zobrazeno 1 - 10
of 29
pro vyhledávání: '"O T, Raitakari"'
Autor:
Tiinamaija Tuomi, Taru Tukiainen, Sanni Ruotsalainen, Ari Ahola-Olli, Mika Kähönen, Mars Nt, Leevi Lehtonen, O T Raitakari, Jaakko T. Leinonen, Samuli Ripatti, Terho Lehtimäki, Mark J. Daly, Matti Pirinen
Testosterone (T) is linked with diverse characteristics of human health, yet, whether these associations reflect correlation or causation remains debated. Here, we provide a broad perspective on the role of T on complex diseases in both sexes leverag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::420e68f0a3ee3e863d8c1f86038ce5e8
https://doi.org/10.1101/2021.04.23.21255981
https://doi.org/10.1101/2021.04.23.21255981
Autor:
O T Raitakari, Terho Lehtimäki, Mika Kähönen, M Hurme, Sara N. Lundgren, Markus Perola, Kirsi H. Pietiläinen, Satu Männistö, Miina Ollikainen, Kuitunen S, J Kaprio
BackgroundObesity is a heritable complex phenotype which can increase the risk of age-related outcomes. Biological age can be estimated from DNA methylation (DNAm) using various “epigenetic clocks.” Previous work suggests individuals with elevate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c69ef5c7049f617c4669d985ffc5e008
https://doi.org/10.1101/2021.03.11.21253271
https://doi.org/10.1101/2021.03.11.21253271
Autor:
Tobias Kurth, Nadine Pelzer, Hautakangas H, Artto, O T Raitakari, Julie E. Buring, Penninx Bwjh., Christian Erikstrup, Mikko Kallela, Matti Pirinen, Christian Benner, Daniel I. Chasman, Kristian Hveem, Kristoffersen Es, Torben Hansen, Olafur A. Sveinsson, Mika Kähönen, van den Maagdenberg Amjm., Mona Ameri Chalmer, Aarno Palotie, Elisabeth Widen, Thorgeir E. Thorgeirsson, Hreinn Stefansson, Lighart L, Paul M. Ridker, de Boer I, Gisela M. Terwindt, Garbrielsen Me, Jouke J. Hottenga, Kogelman Lja., Arpo Aromaa, Bendik S. Winsvold, Dale R. Nyholt, Ikram Ma, van Dijk Kw, Harder Ave, Martin Dichgans, Rainer Malik, Mohsen Ghanbari, Marianne Bakke Johnsen, Marjo-Ritta Jarvelin, Samuli Ripatti, Paavo Häppölä, Gyda Bjornsdottir, Martti Färkkilä, Anne Heidi Skogholt, Terho Lehtimäki, Sanni Ruotsalainen, Frits R. Rosendaal, Gudrun R. Sigurdardottir, Headache Ha, Gormley P, Kari Stefansson, J.A. Zwart, Oluf Pedersen, Raymond Noordam, Ben Michael Brumpton, Laurent F. Thomas, Karina Banasik, M.G. Hrafnsdottir, Lisanne S. Vijfhuizen, Sølvsten Burgdorf K, Jes Olesen, Sigurdur H. Magnusson, T. Freilinger, Kristen Hagen, Andrea Carmine Belin, Dorret I. Boomsma, Henrik Ullum, Maija Wessman, Ran C, Anna Bjornsdottir
Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. This genome-wide association study (GWAS) of 102,084 migraine cases and 771,257 controls identified 123 loci of which 86 are novel. The loci p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e64e0da2e2c833014db37279373369e
https://doi.org/10.1101/2021.01.20.21249647
https://doi.org/10.1101/2021.01.20.21249647
Autor:
Tom G. Richardson, Katja Pahkala, Kurt Taylor, Juha Mykkänen, Joshua A. Bell, Terho Lehtimäki, Mika Ala-Korpela, Jorma Viikari, O T Raitakari, G Davey Smith
BackgroundIndividuals who are obese in childhood have an elevated risk of cardiometabolic disease in adulthood. However, whether childhood adiposity directly impacts intermediate markers of this risk, independent of adult adiposity, is unclear.Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3bf68f2b84b8766f682433f4a25a9f2
https://doi.org/10.1101/2020.08.25.20181412
https://doi.org/10.1101/2020.08.25.20181412
Autor:
Marko Salmi, Sylvain Sebert, Sirpa Jalkanen, Mark J. Ponsford, Saranya Palaniswamy, Simon Jones, Martin Dichgans, M-R Jarvelin, Dipender Gill, Kostas Tsilidis, Salomaa, Juha Auvinen, Juha Veijola, O T Raitakari, Karl-Heinz Herzig, Minna Männikkö, Ahola-Olli A, Areti Papadopoulou, Sirkka Keinänen-Kiukaanniemi, Terho Lehtimäki, Shivaprakash Jagalur Mutt, Markku Timonen, Abbas Dehghan, Karhunen, Rainer Malik
Publikováno v:
medRxiv
Cytokines are the signalling molecules that underlie inflammatory processes. Here, we performed genome-wide association study (GWAS) analyses of 47 circulating cytokines in up to 13,365 individuals to identify protein quantitative trait loci (pQTL).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84871bc3d837f6e2a384af4046c54724
Publikováno v:
European Heart Journal. 40
Background Indoleamine 2,3-dioxygenase (IDO) is an intracellular enzyme that has an important immunomodulator function. Human inflammatory response promotes upregulation of IDO level in blood. This may lead to suppression of inflammation in atheroscl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6973156461bfa0368cef6cc73a85dee2
https://doi.org/10.1093/eurheartj/ehz745.0335
https://doi.org/10.1093/eurheartj/ehz745.0335
Autor:
Peter D. Sly, Re Foong, Ozren Polasek, Nicole Probst-Hensch, Ian P. Hall, Graham L. Hall, Tobin, Pirro G. Hysi, Teemu Palviainen, Mika Kähönen, Veronique Vitart, Louise V. Wain, Carl A. Melbourne, Don D. Sin, Anna L. Guyatt, Henry Völzke, Ca Wang, Katherine A. Fawcett, David J. Porteous, John M. Starr, Claudia Langenberg, Igor Rudan, Ke Hao, Stefan Weiss, Terho Lehtimäki, Kirsi H. Pietiläinen, David M. Evans, Ian J. Deary, Jian'an Luan, James F. Wilson, David P. Strachan, Taina Rantanen, Catherine John, Nicola Pirastu, O T Raitakari, Berge M van den, Karina Patasova, Claudia Flexeder, Medea Imboden, Thibaud Boutin, Mangino Massimo, Archie Campbell, Lucija Klaric, Leo-Pekka Lyytikäinen, Nick Shrine, Sebastian May-Wilson, Beate Stubbe, Ralf Ewert, Dirk Keidel, Sarah E. Harris, Tim D. Spector, Ma'en Obeidat, John Henderson, Cosetta Minelli, Moksnes, Raquel Granell, Blair H. Smith, Arnulf Langhammer, Craig E. Pennell, Nicholas J. Wareham, Caroline Hayward, Ben Michael Brumpton, Yohan Bossé, Peter K. Joshi, Susan M. Ring, Sandosh Padmanabhan, Cristen J. Willer, Kristian Hveem, Deborah Jarvis, J Kaprio, Laura Portas, Anne Richmond
Adult lung function is highly heritable and 279 genetic loci were recently reported as associated with spirometry-based measures of lung function. Though lung development and function differ between males and females throughout life, there has been n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d8b91786df855b049a3c8f757942a6
https://doi.org/10.1101/594457
https://doi.org/10.1101/594457
Autor:
Peppi Koivunen, Elitsa Y. Dimova, O T Raitakari, Karhunen, Pasi Soininen, Terho Lehtimäki, Katri Puukka, Juha Auvinen, Mika Kähönen, M-R Jarvelin, Mika Ala-Korpela, Johannes Kettunen, Joona Tapio, Emma Raitoharju, Raisa Serpi, Tuija Tammelin, Juha Mykkänen, Sirkka Keinänen-Kiukaanniemi
Hemoglobin (Hb) is the main carrier of oxygen. In general, high-end Hb levels within the normal range are considered beneficial for health1. However, activation of the hypoxia response has been shown to protect mice against metabolic dysfunction2-4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a743b5fe80a0c4d26f327532f6b340
P5362Metabolomic signature of incident type 2 diabetes: evidence from NMR in over 18,000 individuals
Autor:
Veikko Salomaa, Jorma Viikari, A. V. Ahola-Olli, Terho Lehtimäki, Tapani Rönnemaa, Markus Juonala, Pasi Soininen, Markus Perola, J. Jokelainen, Johannes Kettunen, Marjo-Riitta Järvelin, Peter Würtz, Mika Ala-Korpela, Antti J. Kangas, O T Raitakari
Publikováno v:
European Heart Journal. 38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6f53e1e53f22735ce7f90b8cabc1a8d
https://doi.org/10.1093/eurheartj/ehx493.p5362
https://doi.org/10.1093/eurheartj/ehx493.p5362
Autor:
Nina Tolonen, Ville-Petteri Mäkinen, Pasi Soininen, Carol Forsblom, Lena M. Thorn, O T Raitakari, Mika Ala-Korpela, Markku J. Savolainen, Jorma Viikari, Annika Kangas, Per-Henrik Groop
Publikováno v:
Journal of Internal Medicine; Vol 273
Background Circulating cholesterol (C) and triglyceride (TG) levels are associated with vascular injury in type 1 diabetes (T1DM). Lipoproteins are responsible for transporting lipids, and alterations in their subclass distributions may partly explai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6404e95524aba9bd48f65c4d655afc2a
https://doi.org/10.1111/joim.12026
https://doi.org/10.1111/joim.12026