Zobrazeno 1 - 10
of 46
pro vyhledávání: '"O S Zhukova"'
Publikováno v:
Bulletin of Experimental Biology and Medicine. 169:130-136
We studied cytotoxic activity of new tetranitrosyl NO-generating binuclear iron-sulfur [Fe-S] complexes containing different ligands in the molecule against tumor cells in vitro. Cytotoxic activity of the most active complex with cysteamine (CysAm) w
Autor:
O. V. Goryunova, G. N. Apryshko, L. V. Fetisova, R. B. Pugacheva, O. S. Zhukova, N. K. Vlasenkova
Publikováno v:
Russian Journal of Biotherapy. 16:46-54
Objective: to evaluate the prospects of the glycosides of indolocarbazole containing amino acid residues as potential antitumor compounds. Materials and methods. For 32 compounds by structural formulas using the methods of chemoinformatics, a number
Publikováno v:
Bulletin of experimental biology and medicine. 162(4)
We studied cytotoxic activity of a new NO-releasing tetranitrosyl binuclear iron complex with cysteamine (CysAm) for human tumor cells, the relationship between the expression of O6-methylguanine-DNA methyltransferase (MGMT) and cell sensitivity to C
Autor:
O S, Zhukova, L V, Fetisova, A V, Trishin, N Yu, Anisimova, A M, Scherbakov, A E, Shcherbakov, D V, Yashunskii, D E, Tsvetkov, V M, Men'shov, M V, Kiselevskii, N E, Nifant'ev
Publikováno v:
Bulletin of Experimental Biology and Medicine. 149:511-514
Here we present antiestrogenic effects of Knotolan, a new dietary lignan from Abies sibirica raw material. Knotolan abolished growth-stimulating effects of 17β-estradiol on hormone-dependent MCF-7 cells.
Publikováno v:
Russian Journal of Bioorganic Chemistry. 36:377-382
Novel 2,3-seco-triterpenic amides were prepared by the interaction of the chloride of 1-cyano-19β,28-epoxy-18α-oleane-3-oic acid with primary amines and synthetic and biogenic amino acids. A cytotoxic triterpenic conjugate with a residue of the eth
Publikováno v:
Russian Journal of Physical Chemistry A. 81:1525-1531
The adsorption of H2O and D2O on porous polymers, Chromosorb-102 (styrene-divinylbenzene copolymer) and MN-200 (supercross-linked polystyrene), was studied by gas chromatography. Test adsorbates used to study the properties of the surface of these po
Publikováno v:
Bulletin of Experimental Biology and Medicine. 144:231-234
We studied the ability of lymphokine-activated killer cells to lyse A549 human non-small cell lung cancer cells after preincubation with cisplatin. Lymphokine-activated killer cells obtained after incubation of human blood lymphocytes with interleuki
Publikováno v:
Russian Journal of Physical Chemistry A. 81:479-482
The adsorption properties of γ-Al2O3 were studied using gas chromatography. Isotherms of adsorption of n-alkanes (C6–C9), hex-1-ene, benzene, and isobutanol were measured within 70–100°C. The isosteric heats of adsorption and contributions to t
Publikováno v:
Bioorganicheskaia khimiia. 40(1)
N6-derivatives of N12-indolo[2,3-a]pirrolo[3,4-c]carbazole-5,7-dione are synthesized as potential antitumor agents. The pyrrol N6 atom of these compounds is included into the dipeptide residue of the general formula >N6-(CH2) n -CO-Ala/βAla-OMe (n =
[Synthesis, structure and farmacologycal activity of (7R,8S)-epoxy-(13R,17R)-trioxolaneabietic acid]
Autor:
Oxana B. Kazakova, Dmitri V. Kazakov, Elena V. Tretyakova, Farit E. Safarov, G. N. Apryshko, A. F. Ismagilova, Tkhankh Tra Nguen, Tolstikov Genrikh A, O. S. Zhukova, I. V. Chudov, H. Do Tkhi Tkhu, N. I. Medvedeva, T. I. Nazyrov, I. E. Smirnova, K. Yu. Suponitsky
Publikováno v:
Bioorganicheskaia khimiia. 39(2)
The synthesis and X-ray diffraction established the structure of (7R,8S)-(see text for symbol)-(13R,17R)-trioxolaneabietic acid. Predicted by the computer system PASS antineoplastic activity and the ability to induce apoptosis, a mechanism of cell de