Zobrazeno 1 - 8 of 8 pro vyhledávání: '"O Petter Veiby"'
1
Akademický článek
A monomethyl auristatin E-conjugated antibody to guanylyl cyclase C is cytotoxic to target-expressing cells in vitro and in vivo.
Autor: Melissa Gallery, Julie Zhang, Daniel P Bradley, Pamela Brauer, Donna Cvet, Jose Estevam, Hadi Danaee, Edward Greenfield, Ping Li, Mark Manfredi, Huay-Keng Loke, Claudia Rabino, Brad Stringer, Mark Williamson, Tim Wyant, Johnny Yang, Qing Zhu, Adnan Abu-Yousif, O Petter Veiby
Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0191046 (2018)
Guanylyl cyclase C (GCC) is a cell-surface protein that is expressed by normal intestinal epithelial cells, more than 95% of metastatic colorectal cancers (mCRC), and the majority of gastric and pancreatic cancers. Due to strict apical localization,
Externí odkaz: https://doaj.org/article/a7f83c04c46d4ef7a8377d00d5a34370
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5
A monomethyl auristatin E-conjugated antibody to guanylyl cyclase C is cytotoxic to target-expressing cells in vitro and in vivo
Autor: Tim Wyant, Melissa Gallery, Daniel Bradley, Adnan O. Abu-Yousif, Mark Williamson, Jose Estevam, Qing Zhu, Ping Li, Johnny J. Yang, Mark Manfredi, Claudia Rabino, Huay-Keng Loke, Edward A. Greenfield, O. Petter Veiby, Julie Zhang, Brad Stringer, Hadi Danaee, Donna Cvet, Pamela Brauer
Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0191046 (2018)
PLoS ONE
Guanylyl cyclase C (GCC) is a cell-surface protein that is expressed by normal intestinal epithelial cells, more than 95% of metastatic colorectal cancers (mCRC), and the majority of gastric and pancreatic cancers. Due to strict apical localization,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19937fd8f3e2cac3892c813081c2842b
http://europepmc.org/articles/PMC5784926?pdf=render
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6
Abstract 3916: Relationship of guanylyl cyclase C (GCC) expression and efficacy of TAK-164, a GCC-targeted antibody-drug conjugate in a panel of 68 subcutaneous HuPrime colorectal cancer PDX models
Autor: Adnan O. Abu-Yousif, Bradley Stringer, Mengkun Zhang, Erik Koenig, Brittany Bahamon, O. Petter Veiby, Cong Li, Bret Bannerman, Andy Z. X. Zhu, Huyuan Yang, Pooja Shah, Kazuho Nishimura
Publikováno v: Cancer Research. 78:3916-3916
Guanylyl cyclase C (GCC) is a cell surface protein expressed in more than 95% of metastatic colorectal cancers and in the majority of gastric and pancreatic cancers, making GCC an attractive antibody-drug conjugate (ADC) target. TAK-164 is an ADC com
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5129adc92ec8e99c3f1eae27136468fe
https://doi.org/10.1158/1538-7445.am2018-3916
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7
Abstract B120: TAK-164, a GCC-targeted antibody-drug conjugate (ADC) for the treatment of colorectal cancers and other GI malignancies
Autor: Cindy Q. Xia, Afrand Kamali, Mark G. Qian, Bradley Stringer, Thomas A. Keating, Kurt Eng, Michelle L. Ganno, Michael D. Smith, Secil Koseoglu, Bret Bannerman, O. Petter Veiby, Jayaprakasam Bolleddula, Katharine C. Lai, Donna Cvet, Melissa Gallery, Adnan O. Abu-Yousif
Publikováno v: Molecular Cancer Therapeutics. 17:B120-B120
TAK-164 is an antibody-drug conjugate comprising a full-length, fully human IgG1 monoclonal antibody (mAb) directed towards the extracellular domain of guanylyl cyclase C (GCC). The mAb is conjugated using the peptide-linked indolino-benzodiazepine D
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7934fdd47b4d5a9502a97e29622d9b44
https://doi.org/10.1158/1535-7163.targ-17-b120
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8
Akademický článek
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