Zobrazeno 1 - 10
of 10
pro vyhledávání: '"O O, Ryabaya"'
Autor:
O. O. Ryabaya, A. A. Prokofieva
Publikováno v:
Успехи молекулярной онкологии, Vol 7, Iss 2, Pp 8-19 (2020)
Autophagy and epithelial-to-mesenchymal transition (EMT) are the main biological processes involved in tumor progression, and are closely linked. On the one hand, activation of autophagy provides energy and essential nutrients for EMT during the meta
Externí odkaz:
https://doaj.org/article/f3cef8746ad746ada41b609cb1cb3eaf
Autor:
A. A. Vartanian, O. S. Burova, Kh. S. Vishnyakova, I. V. Samoylenko, V. A. Misyurin, E. E. Egorov, O. O. Ryabaya, M. A. Baryshnikova
Publikováno v:
Успехи молекулярной онкологии, Vol 6, Iss 4, Pp 47-57 (2019)
Background. Activating mutations in the BRAF gene leads to a constitutive activation of the MAPK signaling. The highly selective BRAFV600E inhibitor, vemurafenib, improves the overall survival of BRAF-mutant melanoma patients. However, despite the ex
Externí odkaz:
https://doaj.org/article/2c60eba51be74945a5a4cbe6c09cdbeb
Autor:
O. O. Ryabaya, A. A. Prokofieva, D. A. Khochenkov, R. A. Akasov, S. V. Burov, E. A. Markvicheva, E. V. Stepanova
Publikováno v:
Сибирский онкологический журнал, Vol 18, Iss 3, Pp 54-63 (2019)
Introduction. Cutaneous melanoma is a challenge to treat due to rapid progression of disease and acquired resistance to therapy. Autophagy and the epithelial-to-mesenchymal transition (EMT) are closely interrelated and play a key role in tumor progre
Externí odkaz:
https://doaj.org/article/7976f6fa311a426aaf368f305bc99661
The role of autophagy inhibition in the enhanced cytotoxicity of temozolomide on melanoma cell lines
Autor:
O. O. Ryabaya, A. N. Inshakov, A. A. Malysheva, I. S. Abramov, N. V. Sholina, D. A. Khochenkov, E. V. Stepanova
Publikováno v:
Успехи молекулярной онкологии, Vol 4, Iss 3, Pp 75-82 (2017)
Background. Despite advantages in treatment of metastatic melanoma it remains resistant to current therapy. Recent evidence indicates that tumor cells could overcome death through autophagy, a process that degrades cellular proteins and organelles to
Externí odkaz:
https://doaj.org/article/64f31968e27d49eaa26f9b75033fac70
Autor:
O. O. Ryabaya, L. A. Ostrovskaya, E. I. Nekrasova, D. B. Korman, K. A. Abzaeva, N. V. Bluhterova
Publikováno v:
Biophysics. 64:930-935
The cytotoxic effect of the antitumor drug aurumacryl (gold polyacrylate) against human tumor cells of various origins has been studied. It has been shown that aurumacryl exhibits significant cytotoxic activity against cells of lung carcinoma А549 (
Publikováno v:
Molecular Biology. 52:398-405
Publikováno v:
Molekuliarnaia biologiia. 53(4)
Acral melanoma is one of the most aggressive and fast-growing forms of cutaneous melanoma and is characterized by a predominant location on the palms and feet. Primary tumors, metastases, and normal tissue samples from five acral melanoma patients we
Autor:
Y I, Ammour, O O, Ryabaya, A V, Milovanova, A V, Sidorov, I E, Shohin, V V, Zverev, T V, Nasedkina
Publikováno v:
Molekuliarnaia biologiia. 52(4)
The oncolytic potential of the attenuated mumps virus (MV) vaccine strain Leningrad-3 (L-3) was evaluated in a panel of four human metastatic melanoma cell lines. The lines were shown to be susceptible and permissive to MV infection. Efficient MV rep
Publikováno v:
Molekuliarnaia biologiia. 52(3)
The discovery of B-RAF activating mutations in malignant melanoma cells has led to the development of a number of targeted drugs, which block exclusively the mutant B-RAF protein. Tumor cells often acquire resistance to B-RAF inhibitors via activatio
Publikováno v:
Doklady. Biochemistry and biophysics. 478(1)
The possibility of using VEGF-R1 receptor for targeted therapy in oncology was investigated. Using the approach to measuring the protein content in intact nuclei of cells, which was developed by us, we showed the presence of this receptor in the nucl