Zobrazeno 1 - 10
of 324
pro vyhledávání: '"O Nikaido"'
Publikováno v:
Mutation Research/DNA Repair. 293:143-150
Xeroderma pigmentosum complementation group A was partially complemented by a cosmid genomic clone containing a 42-kb human DNA insert selected with a cDNA clone that we obtained through cDNA competition between the repair-proficient and repair-defic
Autor:
E, Otoshi, T, Yagi, T, Mori, T, Matsunaga, O, Nikaido, S T, Kim, K, Hitomi, M, Ikenaga, T, Todo
Publikováno v:
Cancer research. 60(6)
The role of UV light-induced photoproducts in initiating base substitution mutation in human cells was examined by determining the frequency and spectrum of mutation in a supF tRNA gene in a shuttle vector plasmid transfected into DNA repair deficien
Publikováno v:
The British journal of dermatology. 140(2)
Major photoproducts induced by carcinogenic ultraviolet (UV) radiation are the cylobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone (6-4) photoproducts (6-4 PPs). 8-Hydroxy-2 -deoxyguanosine (8-OHdG) is also a DNA base-modified product gener
Publikováno v:
Nucleic acids symposium series. (37)
A monoclonal antibody (TDM-2) specific to a UV-induced cyclobutane pyrimidine dimer has previously been established. We investigated here the structural requirements of antigen recognition by the antibody using chemically synthesized antigen analogs.
Publikováno v:
Laboratory animal science. 46(4)
We introduced two mutant genes (beige or bg, which induces a deficiency of natural killer activity, and xid, which decreases the production of immunoglobulins) into KSN nude mice with high reproductive performance. At first we produced the KSN-bg/bg(
Publikováno v:
Cancer research. 55(11)
Immunocytochemistry was used for the direct measurement of cyclobutane pyrimidine dimers, (6-4) photoproducts, and Dewar isomers in normal human mononuclear cells following irradiation by natural sunlight or by a FS20 broad spectrum UVB sunlamp. The
Publikováno v:
Anticancer research. 15(3)
Human osteosarcoma cells, that were cultured to confluence and maintained under low nutrient conditions, showed potentially lethal damage repair after cisplatin treatment. This repair was inhibited by a non-toxic dose of caffeine. Flow cytometric ana
Autor:
N W Schipper, T Matsunaga, A J Cohen, O Nikaido, Antony R. Young, Caroline A Chadwick, Christopher S Potten
Publikováno v:
International journal of radiation biology. 63(3)
The incidence of the various types of skin cancer in the general population has been increasing at an annual rate of 2-8% over the past 2 decades. In spite of considerable media coverage on the risk of skin cancer the acquisition of a suntan is still
Publikováno v:
Cancer research. 53(3)
UVS1 is an intermediately UV-sensitive Chinese hamster ovary mutant originally isolated by its hypersensitivity to an anticancer drug, 1-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-3-(2-chloroethyl)-3-nitrosour ea hydrochloride. By cell fusion analysis,
Autor:
C F, Arlett, J E, Lowe, S A, Harcourt, A P, Waugh, J, Cole, L, Roza, B L, Diffey, T, Mori, O, Nikaido, M H, Green
Publikováno v:
Cancer research. 53(3)
T-lymphocytes from three normal human donors, irradiated with broad-spectrum UV-B (peak emission, 312 nm), are 20-fold more sensitive than fibroblasts from four normal donors in a clonogenic assay. We have compared the formation of thymine cyclobutan