Zobrazeno 1 - 10
of 63
pro vyhledávání: '"O N Shilova"'
Publikováno v:
Molekuliarnaia biologiia. 56(1)
Proteins of the AID/APOBEC family are capable of cytidine deamination in nucleic acids forming uracil. These enzymes are involved in mRNA editing, protection against viruses, the introduction of point mutations into DNA during somatic hypermutation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118cf2bdfbb2d5f307ff107b30904fa0
https://pubmed.ncbi.nlm.nih.gov/35082258
https://pubmed.ncbi.nlm.nih.gov/35082258
Autor:
O N Shilova, Sergey M. Deyev
Publikováno v:
Acta Naturae
Monoclonal antibodies are the classical basis for targeted therapy, but the development of alternative binding proteins has made it possible to use non-immunoglobulin proteins as targeting modules. The advantages of DARPins, scaffold proteins based o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a15d9cca4e22f7eed3d15b588262cb
https://pubmed.ncbi.nlm.nih.gov/31993234
https://pubmed.ncbi.nlm.nih.gov/31993234
Publikováno v:
Journal of Photochemistry and Photobiology B: Biology. 188:107-115
Photodynamic therapy (PDT) is a clinical, minimally invasive method for destroying cancer cells in the presence of a photosensitizer, oxygen, and a light source. The main obstacle for the PDT treatment of deep tumors is a strong reduction of the exci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63eefb3237c6d8885b785194a756927e
https://doi.org/10.1016/j.jphotobiol.2018.09.006
https://doi.org/10.1016/j.jphotobiol.2018.09.006
Publikováno v:
Doklady Biochemistry and Biophysics. 482:245-248
It was found that the fluorescent properties of the phototoxic domain of miniSOG allow to assess the ability of toxins to bind to human breast adenocarcinoma cells SK-BR-3 and study the dynamics of their internalization. We established that the main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cde34da2656d5a82f347c0185bdb698
https://doi.org/10.1134/s1607672918050046
https://doi.org/10.1134/s1607672918050046
Publikováno v:
Journal of Controlled Release. 286:125-136
Despite an enhanced permeability and retention effect typical of many solid tumors, drug penetration is not always sufficient. Possible strategies for the drug delivery improvement are a modification of the tumor cell-to-cell junctions and usage of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abcd0625df74130bd73a500546c98fd
https://doi.org/10.1016/j.jconrel.2018.07.030
https://doi.org/10.1016/j.jconrel.2018.07.030
Publikováno v:
Russian Journal of Bioorganic Chemistry. 44:225-228
The bioluminescent platform based on a genetically engineered luciferase NanoLuc and its synthetic substrate furimazine is widely used in modern molecular biology for optical imaging and therapy of deep tissue tumors. Taking into account the perspect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95051043e5db27854df6883c0b464d16
https://doi.org/10.1134/s1068162018020085
https://doi.org/10.1134/s1068162018020085
Autor:
G. M. Proshkina, D. V. Kiseleva, O. N. Shilova, A. V. Ryabova, E. I. Shramova, O. A. Stremovskiy, S. M. Deyev
Publikováno v:
Molecular Biology. 51:865-873
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3587fd195778a2c9c6be810ee32c7f92
https://doi.org/10.1134/s0026893317060140
https://doi.org/10.1134/s0026893317060140
Publikováno v:
Cytometry Part A. 91:917-925
Controlling background fluorescence remains an important challenge in flow cytometry, as autofluorescence can interfere with the detection of chromophores. Furthermore, experimental procedures can also affect cellular fluorescence in certain regions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd85f91e2e122c7ba129392a9eb12410
https://doi.org/10.1002/cyto.a.23199
https://doi.org/10.1002/cyto.a.23199
Autor:
Oleg A. Stremovskiy, G. M. Proshkina, E. I. Shramova, D V Kiseleva, Anastasiya V. Ryabova, O N Shilova, Sergey M. Deyev
Publikováno v:
Молекулярная биология. :997-1007
We have generated and characterized HER2-specific targeted toxin based on the low-immunogenic variant of Pseudomonas exotoxin A (LoPE), in which most of the human immunodominant B-cell epitopes have been inactivated. Nonimmunoglobulin DARPin-based HE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af3238237bc569dc28fc3f76ef6ee9ca
https://doi.org/10.7868/s0026898417060118
https://doi.org/10.7868/s0026898417060118
Autor:
Alexey A. Schulga, Daria Kiseleva, Sergey M. Deyev, Irina V. Balalaeva, E. A. Sokolova, O N Shilova
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 10
International Journal of Molecular Sciences, Vol 20, Iss 10, p 2399 (2019)
Volume 20
Issue 10
International Journal of Molecular Sciences, Vol 20, Iss 10, p 2399 (2019)
High immunogenicity and systemic toxicity are the main obstacles limiting the clinical use of the therapeutic agents based on Pseudomonas aeruginosa exotoxin A. In this work, we studied the immunogenicity, general toxicity and antitumor effect of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5873f832e09f153de0037e4542245f