Zobrazeno 1 - 10 of 10 pro vyhledávání: '"O N Koç"'
1
Potentiation of lymphomagenesis by methylnitrosourea in mice transgenic for LMO1 is blocked by O6-alkylguanine DNA-alkyltransferase
Autor: S L Gerson, O N Koç, J S Reese, E A McGuire, Esther Allay, N Sedransk
Publikováno v: Oncogene. 15:2127-2132
We evaluated induction of lymphomas by the methylating carcinogen, N-methylnitrosourea [MNU], in transgenic mice expressing both LMO1 and the DNA repair gene, MGMT, in the thymus. The goal was to determine whether environmental mutagens shorten the l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd1175703b80b258f3f1cf8e8db5c07
https://doi.org/10.1038/sj.onc.1201384
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2
Persistent vacuoles in leukocytes: Familial Jordans anomaly
Autor: Nukhet Tuzuner, M Taşyürekli, Lamia Ulukutlu, Fügen Çullu, R A Seger, O N Koç, O N Ulutin, L Sağlamer, F Oz
Publikováno v: Pediatrics International. 37:177-181
Multiple persistent vacuoles were seen in the neutrophils, monocytes and eosinophils of a 9 year old boy and his 10 year old sister. The siblings were both asymptomatic. In the bone marrow, the cytoplasmic vacuoles were also present in the promyelocy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1f2b47bed8ab0a20f1d712711481a6
https://doi.org/10.1111/j.1442-200x.1995.tb03293.x
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4
Limiting numbers of G156A O(6)-methylguanine-DNA methyltransferase-transduced marrow progenitors repopulate nonmyeloablated mice after drug selection
Autor: B M, Davis, O N, Koç, S L, Gerson
Publikováno v: Blood. 95(10)
The limited efficacy of hematopoietic gene therapy can be improved by in vivo selection for transduced long-term repopulating cells (LTRC). We selected for G156A MGMT (triangle upMGMT) transduced LTRC present in 5 x 10(4) to 100 x 10(4) marrow cells
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aafdf9d2ba0659988f60c5b3b493c34b
https://pubmed.ncbi.nlm.nih.gov/10807772
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6
Heterogeneity of O6-alkylguanine-DNA-alkyltransferase measured by flow cytometric analysis in blood and bone marrow mononuclear cells
Autor: L, Liu, K, Lee, J, Schupp, O N, Koç, S L, Gerson
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 4(2)
Alkyltransferase (AGT) repairs alkylation at O6-guanine in DNA and is a major determinant of susceptibility to alkylating chemotherapeutic agents and carcinogens. Using a newly developed flow cytometry assay with the monoclonal anti-AGT antibody, mT3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::102a96c871198f83883f942752a2284a
https://pubmed.ncbi.nlm.nih.gov/9516939
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7
Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea
Autor: B M, Davis, J S, Reese, O N, Koç, K, Lee, J E, Schupp, S L, Gerson
Publikováno v: Cancer research. 57(22)
A retroviral gene therapy approach was developed to protect early hematopoietic progenitors from 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a stem cell toxin, and O6-benzylguanine (BG), an inhibitor of a key BCNU resistance protein, O6-alkylguanine
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::44a8bb08cf967a8207c309aefa097d56
https://pubmed.ncbi.nlm.nih.gov/9371508
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8
Retroviral-mediated gene transduction of human alkyltransferase complementary DNA confers nitrosourea resistance to human hematopoietic progenitors
Autor: J A, Allay, O N, Koç, B M, Davis, S L, Gerson
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 2(8)
Myelosuppression is the dose-limiting toxicity for nitrosourea chemotherapy due to low levels of the DNA repair protein O6-alkylguanine-DNA alkyltransferase in myeloid precursors. We have shown that high-efficiency myeloproliferative sarcoma virus (v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30d569a25b69b39a54b898e232c9a8fd
https://pubmed.ncbi.nlm.nih.gov/9816307
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9
Transfer of drug resistance genes into hematopoietic progenitors to improve chemotherapy tolerance
Autor: O N, Koç, J A, Allay, K, Lee, B M, Davis, J S, Reese, S L, Gerson
Publikováno v: Seminars in oncology. 23(1)
A number of drug resistance genes have been identified that may be useful in gene therapy approaches to ameliorate chemotherapy toxicity. Hematopoietic tissue is the most suitable target for drug resistance gene therapy because myelosuppression is th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba026d354f9450f62e20211ea1c222a7
https://pubmed.ncbi.nlm.nih.gov/8607032
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10
Role of DNA repair in resistance to drugs that alkylate O6 of guanine
Autor: O N, Koç, W P, Phillips, K, Lee, L, Liu, N H, Zaidi, J A, Allay, S L, Gerson
Publikováno v: Cancer treatment and research. 87
The mechanism of cytotoxicity of a number of chemotherapeutic agents involves alkylation at the O6 position of guanine, a site that strongly influences cytotoxicity. Repair of these lesions by the alkyltransferase protects from cytotoxicity and is a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ef733de28e3d9d2fb06009271bd921e
https://pubmed.ncbi.nlm.nih.gov/8886451
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