Increasing morbidity and mortality of candidemia over one decade in a Swiss university hospital

Autor: Emmanouil Glampedakis, Jean-Luc Pagani, O. Marchetti, Laetitia Kalbermatter, Julien Battistolo, Frédéric Lamoth, Bruno Grandbastien, Julien Poissy, Thierry Calandra, Pierre-Yves Bochud, Philippe Eggimann, Lauro Damonti

Publikováno v: Battistolo, Julien; Glampedakis, Emmanouil; Damonti, Lauro; Poissy, Julien; Grandbastien, Bruno; Kalbermatter, Laetitia; Pagani, Jean-Luc; Eggimann, Philippe; Bochud, Pierre-Yves; Calandra, Thierry; Marchetti, Oscar; Lamoth, Frederic (2021). Increasing morbidity and mortality of candidemia over one decade in a Swiss university hospital. Mycoses, 64(12), pp. 1512-1520. Wiley-Blackwell 10.1111/myc.13376
Mycoses, vol. 64, no. 12, pp. 1512-1520

BACKGROUND The epidemiology of candidemia is evolving with raising concern about the emergence of intrinsically resistant non-albicans Candida species and acquisition of antifungal resistance. In addition to microbiological surveys, epidemiological s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d988a1ace274f2d121352524fa6c31
https://doi.org/10.1111/myc.13376

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Dosing strategies of imipenem in neonates based on pharmacometric modelling and simulation

Autor: Eric Giannoni, Monia Guidi, Laurent A. Decosterd, Kim Dao, Chantal Csajka, Pascal André, Nicolas Widmer, Thierry Buclin, Sandra A. Asner, O. Marchetti, Marc Pfister, Aline Fuchs

Publikováno v: The Journal of antimicrobial chemotherapy, vol. 77, no. 2, pp. 457-465

Objectives Imipenem is a broad-spectrum antibacterial agent used in critically ill neonates after failure of first-line treatments. Few studies have described imipenem disposition in this population. The objectives of our study were: (i) to character

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41370c1534b6105d266b635c9f9aaee9
https://pubmed.ncbi.nlm.nih.gov/34791295

Validation and clinical application of a multiplex high performance liquid chromatography - tandem mass spectrometry assay for the monitoring of plasma concentrations of 12 antibiotics in patients with severe bacterial infections

Autor: Sabine Laila Lahrichi, Raphaël Burger, Jean-Luc Pagani, O. Marchetti, Nicole Guignard, Thomas Mercier, Nicolas Widmer, Chantal Csajka, Philippe Eggimann, Pascal André, Bertrand Rochat, Eva Choong, Benoît Pesse, Frédéric Lamoth, Sandra Cruchon, Laurent A. Decosterd, Thierry Buclin, Beatrice Ternon

Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, vol. 1157, pp. 122160
Journal of Chromatography. B (2020) P. 122160

Objective Unpredictable pharmacokinetics of antibiotics in patients with life-threatening bacterial infections is associated with drug under- or overdosing. Therapeutic drug monitoring (TDM) may guide dosing adjustment aimed at maximizing antibacteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf4c34c5310c3ad5cf39f2fa70091f0
https://serval.unil.ch/resource/serval:BIB_2ABB9B287690.P001/REF.pdf

Performance of the T2Candida Panel for the Diagnosis of Intra-abdominal Candidiasis

Autor: Cornelius J. Clancy, Martin Siegemund, Frederic Tissot, Philippe Eggimann, O. Marchetti, Christina Orasch, Minh Hong Nguyen, Thierry Calandra, Kevin Squires, Pierre-Yves Bochud, Frédéric Lamoth, Ursula Flückiger, Stefan Zimmerli

Publikováno v: Lamoth, Frederic; Clancy, Cornelius J; Tissot, Frederic; Squires, Kevin; Eggimann, Philippe; Flückiger, Ursula; Siegemund, Martin; Orasch, Christina; Zimmerli, Stefan; Calandra, Thierry; Marchetti, Oscar; Nguyen, Minh H; Bochud, Pierre-Yves (2020). Performance of the T2Candida Panel for the Diagnosis of Intra-abdominal Candidiasis. Open Forum Infectious Diseases, 7(3), ofaa075. Oxford University Press 10.1093/ofid/ofaa075
Open forum infectious diseases, vol. 7, no. 3, pp. ofaa075
Open Forum Infectious Diseases

Performance of T2Candida for detecting intra-abdominal candidiasis (IAC) was assessed in 48 high-risk patients. T2Candida sensitivity/specificity and positive/negative predictive values were 33%/93% and 71%/74%, respectively. IAC was present in 100%

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c221ad18f03e2ae33aefe395863003
https://boris.unibe.ch/142242/1/ofaa075.pdf