Zobrazeno 1 - 10
of 83
pro vyhledávání: '"O M Colvin"'
Autor:
Clayton A. Smith, Robert W. Storms, O M Colvin, L Shah, A P Trujillo, Susan M. Ludeman, J B Springer
Publikováno v:
Proceedings of the National Academy of Sciences. 96:9118-9123
Because hematopoietic stem cells are rich in aldehyde dehydrogenase (ALDH) activity, we developed a fluorescent substrate for ALDH, termed BODIPY aminoacetaldehyde (BAAA), and tested its potential for isolating primitive human hematopoietic cells. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bdd4f0fc5a0d21410404c4c365f2283
https://doi.org/10.1073/pnas.96.16.9118
https://doi.org/10.1073/pnas.96.16.9118
Publikováno v:
The Journal of Organic Chemistry. 63:7218-7222
To investigate the mechanism(s) of bisalkylation by isophosphoramide mustard (IPM), IPM-beta,beta,beta',beta'-d(4) was synthesized and the products of its reaction with thiosulfate (at pD 7.0) were analyzed by NMR. By both (1)H and (13)C NMR, the dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c75bbe9fef0e8b52a10e638abb2df37
https://doi.org/10.1021/jo980546s
https://doi.org/10.1021/jo980546s
Autor:
Milada S. Vala, John Hilton, O M Colvin, Anita L. Hawkins, James Barber, MJ Fackler, WS May, Barbara A. Zehnbauer, Richard J. Jones, Constance A. Griffin, Michael I. Collector, Saul J. Sharkis
Publikováno v:
Blood. 88:487-491
The classical definition of lymphohematopoietic stem cells (LHSC), the most primitive progenitors of all blood cells, requires that they have the capacity for self-renewal and for the long-term production of all blood cell lineages. However, other ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::378927032f9667b4e67d81ae2fbb76ee
https://doi.org/10.1182/blood.v88.2.487.bloodjournal882487
https://doi.org/10.1182/blood.v88.2.487.bloodjournal882487
Autor:
Darell D. Bigner, Michael L. Graham, David M. Ashley, Geoffrey B. Mccowage, Robert D. Tien, Lisa Meier, J. R. Casey, JM Pipas, Roger E. McLendon, Margaret Duncan-Brown, Janice F. Olson, Elizabeth S. Stewart, Linda D. Ferrell, Tracy Kerby, O M Colvin, Herbert E. Fuchs, Joanne Kurtzberg, Darryl C. Longee, Henry S. Friedman
Publikováno v:
Medical and Pediatric Oncology. 26:387-392
The outcome for patients with pineoblastoma has historically been very poor, with most patients dying of disseminated disease despite irradiation. Furthermore, the low incidence of this tumor has hindered progress toward defining better treatment str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93739bf445e0583e28ea009b4dc1cbb4
https://doi.org/10.1002/(sici)1096-911x(199606)26:6<387::aid-mpo3>3.0.co
https://doi.org/10.1002/(sici)1096-911x(199606)26:6<387::aid-mpo3>3.0.co
Publikováno v:
International Journal of Cancer. 62:605-609
Camptothecin, a naturally occurring inhibitor of the DNA-replicating enzyme topoisomerase I, demonstrated promising anti-tumor activity in pre-clinical testing; however, because of unexpected toxicity and low anti-tumor effects in the initial clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e4d44ab4c3d14225207c25dece41af
https://doi.org/10.1002/ijc.2910620519
https://doi.org/10.1002/ijc.2910620519
Autor:
Deborah K. Armstrong, B Clarke, M J Kennedy, Louise B. Grochow, A M Huelskamp, O. M. Colvin, Nancy E. Davidson, T L Chen, Karen Ohly
Publikováno v:
Journal of Clinical Oncology. 13:1136-1143
PURPOSE Resistance to alkylators may potentially be overcome by drugs that inhibits DNA repair, thus improving the efficacy of high-dose chemotherapy. This trial was performed to determine if novobiocin, an agent that inhibits DNA repair, could be gi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d170b28ddcaf39a5167b350072f5d2
https://doi.org/10.1200/jco.1995.13.5.1136
https://doi.org/10.1200/jco.1995.13.5.1136
Autor:
Alessandro Olivi, Buahin Kg, Judy Kd, Abraham J. Domb, Jonathan I. Epstein, Henry Brem, O M Colvin
Publikováno v:
Journal of Neurosurgery. 82:481-486
✓ Most malignant gliomas grow despite treatment by standard chemotherapeutic agents. The authors explored the use of an innovative drug, 4-hydroperoxycyclophosphamide (4HC), delivered via a controlled-release biodegradable polymer to determine whet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6710373216c03dc5a6524420e19b196
https://doi.org/10.3171/jns.1995.82.3.0481
https://doi.org/10.3171/jns.1995.82.3.0481
Publikováno v:
Cancer Chemotherapy and Pharmacology. 37:242-246
Cyclophosphamide is one of the most active agents in the treatment of medulloblastoma. However, development of resistance to this alkylator frequently occurs and is the harbinger of tumor progression and death. In order to understand the biochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea03106d57cf63626b292c29565a44cd
https://doi.org/10.1007/bf00688323
https://doi.org/10.1007/bf00688323
Autor:
Michael L. Graham, Gertrude B. Elion, R H Aaron, Darell D. Bigner, Henry S. Friedman, O M Colvin, Stephen T. Keir
Publikováno v:
Cancer Chemotherapy and Pharmacology. 35:127-131
We evaluated the antitumor activity of busulfan against a panel of tumor cell lines and xenografts in athymic nude mice derived from childhood high-grade glioma, adult high-grade glioma, ependymoma, and medulloblastoma. Busulfan displayed similar act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd2d091a01e2609e434c1e7eecb3101
https://doi.org/10.1007/bf00686634
https://doi.org/10.1007/bf00686634
Publikováno v:
Blood. 75:1947-1950
Relative levels of cytoplasmic aldehyde dehydrogenase (ALDH) were determined in selected subpopulations of normal human bone marrow cells using a flow cytometric assay that simultaneously detects a cell surface antigen (as a marker of cell lineage an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ade02ae6dbc9f48da2d5baed3c7f4e5
https://doi.org/10.1182/blood.v75.10.1947.1947
https://doi.org/10.1182/blood.v75.10.1947.1947