Zobrazeno 1 - 10
of 18
pro vyhledávání: '"O L, Sharko"'
Publikováno v:
Proceedings of the National Academy of Sciences of Belarus, Chemical Series. 58:398-406
A synthetic protocol was developed and optimal reagents have been selected for obtaining guide RNA oligonucleotides for the CRISPR/Cas system using ASM-2000 automatic synthesizer in 500 nmol scale. Methods for the isolation, purification and analytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48457435105d309e9e521b1552dcecf5
https://doi.org/10.29235/1561-8331-2022-58-4-398-406
https://doi.org/10.29235/1561-8331-2022-58-4-398-406
Publikováno v:
Russian Journal of Bioorganic Chemistry. 46:187-198
A comparative analysis of the interaction of the chimeric protein BCR-ABL, of the normal type and with the T315I mutation, with known inhibitors as well as compounds potentially capable of inhibiting the mutant protein has been carried out by compute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fae297459828b45ba3cb51bff1be37d
https://doi.org/10.1134/s1068162020020089
https://doi.org/10.1134/s1068162020020089
Autor:
A M, Firsov, M S F, Franco, D V, Chistyakov, S V, Goriainov, M G, Sergeeva, E A, Kotova, M A, Fomich, A V, Bekish, O L, Sharko, V V, Shmanai, R, Itri, M S, Baptista, Y N, Antonenko, M S, Shchepinov
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Lipid peroxidation (LPO) plays a key role in many age-related neurodegenerative conditions and other disorders. Light irradiation can initiate LPO through various mechanisms and is of importance in retinal and dermatological pathologies. The introduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef71766339a5d6f8602e956aa10fe04c
https://doi.org/10.1016/j.jphotobiol.2022.112425
https://doi.org/10.1016/j.jphotobiol.2022.112425
Autor:
Nina Entelis, Konstantin Severinov, Vadim V. Shmanai, Natalia Nikitchina, Ilya O. Mazunin, Nikita Shebanov, Regina Tkach, Vladimir Mekler, Egor A. Ulashchik, Ivan Tarassov, O. L. Sharko
CRISPR RNAs (crRNAs) directing target DNA cleavage by type V-A Cas12a nucleases consist of repeat-derived 5’-scaffold moiety and 3’-spacer moiety. We demonstrate that removal of most of the 20-nucleotide scaffold has only a slight effect on in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc73c67a15281bf4fe8b2dc61d75caf
https://doi.org/10.1101/2020.12.21.423781
https://doi.org/10.1101/2020.12.21.423781
Publikováno v:
Proceedings of the National Academy of Sciences of Belarus, Chemical Series. 54:197-203
Polyethyleneglycol (PEG) is nontoxic, nonimmunogenic, hydrophilic, chargeless and nonbiodegradable poliymer. Its usage as a part of therapeutics protein drugs is common in medicine practice. It is known that covalent attachment of PEG conduces to pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1142766f211c0ea1641fdac4442ea6ef
https://doi.org/10.29235/1561-8331-2018-54-2-197-203
https://doi.org/10.29235/1561-8331-2018-54-2-197-203
Publikováno v:
Proceedings of the National Academy of Sciences of Belarus, Chemical Series. 54:72-79
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b8f5772b31c8f893b1736f409696688
https://doi.org/10.29235/1561-8331-2018-54-1-72-79
https://doi.org/10.29235/1561-8331-2018-54-1-72-79
Publikováno v:
Proceedings of the National Academy of Sciences of Belarus, Chemical Series. 54:46-57
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::871f5af636ef794b9d02a97c4dc6def3
https://doi.org/10.29235/1561-8331-2018-54-1-46-57
https://doi.org/10.29235/1561-8331-2018-54-1-46-57
Publikováno v:
Russian Journal of General Chemistry. 88:452-461
Alkylation of pentaerythritol symmetrically substituted with propylene glycol with propargyl bromide afforded compounds containing two or three alkyne moieties. Amidophosphite reagents and solid supports were prepared for the introduction of two and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6a0674078b6a16bdf99df2410fcd913
https://doi.org/10.1134/s1070363218030118
https://doi.org/10.1134/s1070363218030118
Autor:
Igor A. Prokhorenko, Maksim V. Kvach, N. V. Pilchenko, M. Yu. Tatulchenkov, Vladimir A. Korshun, O. L. Sharko, Sergey V. Gontarev, Irina A. Stepanova, M. E. Navakouski, Vadim V. Shmanai
Publikováno v:
Russian Journal of Bioorganic Chemistry. 43:386-396
The synthesis of phosphoramidite reagents and solid-phase supports based on hydroxyprolinol for the introduction of the residues of biotin, lipoic acid, amino groups, and terminal acetylene groups at different positions of the oligonucleotide chain h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20bc3a71b739acfa5b170832d8c2c207
https://doi.org/10.1134/s1068162017040148
https://doi.org/10.1134/s1068162017040148
Autor:
O. L. Sharko, Alexander M. Firsov, Yuri N. Antonenko, Mikhail S. Shchepinov, Andrei V. Bekish, Elena A. Kotova, Vadim V. Shmanai, Maksim A. Fomich
Publikováno v:
Biophysical Journal. 118:229a-230a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1b7dd42d4fc01fd091328a7a0fd3bef
https://doi.org/10.1016/j.bpj.2019.11.1358
https://doi.org/10.1016/j.bpj.2019.11.1358