Zobrazeno 1 - 10
of 57
pro vyhledávání: '"O J Finn"'
Publikováno v:
The Journal of Immunology. 155:4766-4774
Epithelial cell mucin encoded by the MUC-1 gene is overexpressed and aberrantly glycosylated on pancreatic, breast, and ovarian cancers as well as on multiple myelomas. It is recognized by patients' Ab and by T cells derived from tumor-draining lymph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a9ec0638bff701450bfac0b6d872d7a
https://doi.org/10.4049/jimmunol.155.10.4766
https://doi.org/10.4049/jimmunol.155.10.4766
Publikováno v:
The Journal of Immunology. 153:3630-3638
The aim of our study was to examine the potential usefulness of transducing the protein kinase C-gamma (PKC-gamma) cDNA gene into tumor-specific T cells as a technique for facilitating the generation of large numbers of functional Ag-specific T for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ee6a311ed71cce2e796d2ada37e7cd0
https://doi.org/10.4049/jimmunol.153.8.3630
https://doi.org/10.4049/jimmunol.153.8.3630
Publikováno v:
The Journal of Immunology. 151:3693-3703
CTL isolated from tumor infiltrating lymphocytes/tumor associated lymphocytes (TAL) infiltrating ovarian tumors have been demonstrated to mediate lysis of tumor targets after in vitro culture. These effector cells are of particular interest as cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aafd80b1bcf174ba8afba2cfa852989
https://doi.org/10.4049/jimmunol.151.7.3693
https://doi.org/10.4049/jimmunol.151.7.3693
Publikováno v:
The Journal of Immunology. 151:1654-1662
Human breast and pancreatic adenocarcinomas are tumors of ductal epithelial cell origin and as such produce and express on their surface polymorphic epithelial cell mucin encoded by the MUC 1 gene. We have previously reported that tumor-specific cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::969c40288e77d7ce665d57f73a261e3d
https://doi.org/10.4049/jimmunol.151.3.1654
https://doi.org/10.4049/jimmunol.151.3.1654
Publikováno v:
The Journal of Immunology. 146:1099-1103
The molecular pathways that are responsible for delivering the proliferative signals from the cell surface to the nucleus in T lymphocytes are still unresolved, but recent data implicates protein kinase C (PKC) involvement in the TCR signaling pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4541b3057b6fc6a1e6580eb9f0d80fc
https://doi.org/10.4049/jimmunol.146.4.1099
https://doi.org/10.4049/jimmunol.146.4.1099
Autor:
Binfeng Lu, O J Finn
Publikováno v:
Cell death and differentiation. 15(1)
Cancer patients mount adaptive immune responses against their tumors. However, tumor develops many mechanisms to evade effective immunosurveillance. T-cell death caused by tumor plays a critical role in establishing tumor immunotolerance. Chronic sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f481767097c1566f2a0981c090c1ea2a
https://pubmed.ncbi.nlm.nih.gov/18007660
https://pubmed.ncbi.nlm.nih.gov/18007660
Autor:
L A, Vella, O J, Finn
Publikováno v:
Novartis Foundation symposium. 279
The immune system is alerted to the presence of a pathogen through the activation of the innate immune system. The message is transmitted to the cells of the adaptive immunity through activated antigen-presenting cells. The development of specific im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9a9bc9c5a61214499c73af0e86482869
https://pubmed.ncbi.nlm.nih.gov/17278396
https://pubmed.ncbi.nlm.nih.gov/17278396
Autor:
J, Schmielau, O J, Finn
Publikováno v:
Cancer research. 61(12)
Impaired T-cell function in patients with advanced cancer has been a widely acknowledged finding, but mechanisms reported thus far are those primarily operating in the tumor microenvironment. Very few mechanisms have been put forth to explain several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9efba8dcd71f8994287d2ac665c8f0a
https://pubmed.ncbi.nlm.nih.gov/11406548
https://pubmed.ncbi.nlm.nih.gov/11406548
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7
Transmembrane glycoprotein tumor antigen MUC1 that is overexpressed on pancreatic and breast tumor cells can be found in large amounts in soluble form in serum and ascites fluid. MUC1 has been identified as a target of human antitumor antibody and CT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f655b6a62d08e1c08c5f9ef640cc9a83
https://pubmed.ncbi.nlm.nih.gov/11300473
https://pubmed.ncbi.nlm.nih.gov/11300473
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7
We describe a method for discovery of new tumor antigens that uses dendritic cells (DCs) as antigen-presenting cells to prime autologous naive CD4+ and CD8+ T cells from healthy donors against tumor proteins and peptides. For the identification of HL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c210583e83743447a056c3a70450081d
https://pubmed.ncbi.nlm.nih.gov/11300472
https://pubmed.ncbi.nlm.nih.gov/11300472