Zobrazeno 1 - 10
of 142
pro vyhledávání: '"O Isozaki"'
Publikováno v:
Journal of Endocrinology. 161:511-516
Growth hormone (GH) is known to interact with adipose tissue and to induce lipolysis. Adipocytes produce leptin which regulates appetite and energy expenditure. In order to elucidate the role of GH in leptin production, we studied the effect of GH on
Autor:
N. Onoda, O. Isozaki, Hiroshi Demura, Toshio Tsushima, M. Arai, M. Miyakawa, Kazuo Shizume, M. Etoh
Publikováno v:
Journal of Endocrinological Investigation. 15:289-295
We summarized the clinical course of 10 patients with silent thyroiditis and evaluated the clinical usefulness of ultrasonography, in combination with clinical and laboratory findings, for the differentiation from Graves' disease. Serum T3 and T4 wer
Publikováno v:
Clinical chemistry. 45(8 Pt 1)
In a previous study, we found that the amino acid substitution R218H in human serum albumin (HSA) was the cause of familial dysalbuminemic hyperthyroxinemia (FDH) in several Caucasian patients. Subsequently the substitution R218P was shown to be the
Autor:
S, Kosugi, Y, Sato, A, Matsuda, Y, Ohyama, K, Fujieda, H, Inomata, T, Kameya, O, Isozaki, S M, Jhiang
Publikováno v:
The Journal of clinical endocrinology and metabolism. 83(11)
A missense and loss of function mutation of the Na+/I- symporter (NIS) gene, T354P [Thr354--Pro (ACA--CCA)], was found in the homozygous state in two unrelated Japanese patients with iodide transport defect. In this study we have identified the homoz
Autor:
H Demura, H. Murakami, Naoya Emoto, M. Miyakawa, M. Arai, T. Tsushima, O Isozaki, Y Nozoe, K. Shizume
Publikováno v:
The Journal of endocrinology. 142(3)
Although endothelins were originally discovered as peptides with vasoconstrictor activity, recent studies have indicated a number of endothelin (ET)-induced hormonal functions in various tissues. We have studied the interaction of endothelins with po
Autor:
O. Isozaki, R. K. Robins, H Demura, N. Onoda, H. Murakami, Naoya Emoto, T. Tsushima, K. Shizume, K. Wakai, E. Ohmura
Publikováno v:
British Journal of Cancer
The effects of cholera toxin (CT) and 8-chloro-cAMP (8-Cl-cAMP) on cell growth were investigated using two human pancreatic carcinoma cell lines (MIA PaCa-2, Panc-1). CT, which catalyses the ADP ribosylation of Gs, suppresses the proliferation of MIA
Publikováno v:
Japanese Journal of Cancer Research : Gann
Glucocorticoids are widely used for the treatment of malignancy‐associated hypercalcemia to delay the occurrence of an escape phenomenon inherent in calcitonin therapy. Using parathyroid hormone‐related protein (PTHrP)‐producing squamous carcin
Autor:
J Y, Chan, M I, Lerman, B S, Prabhakar, O, Isozaki, P, Santisteban, R C, Kuppers, E L, Oates, A L, Notkins, L D, Kohn
Publikováno v:
The Journal of biological chemistry. 264(7)
cDNA clones were isolated by screening a human thyroid carcinoma lambda gt11 library with immunoglobulins purified from serum of a patient with autoimmune Graves' disease. One clone (ML8) containing a 1.25-kilobase (kb) insert hybridized with a singl
Autor:
L D, Kohn, M, Saji, T, Akamizu, S, Ikuyama, O, Isozaki, A D, Kohn, P, Santisteban, J Y, Chan, S, Bellur, C M, Rotella
Publikováno v:
Advances in experimental medicine and biology. 261
A basic reason for undertaking these studies was to further our knowledge of the structure and function of the TSH receptor as well as its interaction with other receptors on thyroid cells. The multiplicity of observations suggests the approach is be
Autor:
M Miyakawa, O. Isozaki, Victoria Savchenko, Vasily Vasko, C De Micco, Kenneth D. Burman, Motoyasu Saji, T Tsushima, Matthew D. Ringel, A Larin, Elena Hardy, H Murakami, M Kruhlak
Publikováno v:
Scopus-Elsevier
Introduction: Akt activation is involved in the pathogenesis of inherited thyroid cancer in Cowden's syndrome and in sporadic thyroid cancers. In cell culture, Akt regulates thyroid cell growth and survival; but recent data suggest that Akt also regu
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