Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes

Autor: J, Yang, Å, Lernmark, U M, Uusitalo, K F, Lynch, R, Veijola, C, Winkler, H E, Larsson, M, Rewers, J-X, She, A G, Ziegler, O G, Simell, W A, Hagopian, B, Akolkar, J P, Krischer, K, Vehik, Dan, Gallo

Publikováno v: International journal of obesity (2005)
Int. J. Obes. 38, 1491-1496 (2014)
International Journal of Obesity; 38(12), pp 1491-1496 (2014)

Objectives:Body size is postulated to modulate type 1 diabetes as either a trigger of islet autoimmunity or an accelerator to clinical onset after seroconversion. As overweight and obesity continue to rise among children, the aim of this study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7612d88a43db2944943fe60dd53def64
https://pubmed.ncbi.nlm.nih.gov/24694666

Pharmacokinetics of aminoguanidine administration and effects on the diabetes frequency in nonobese diabetic mice

Autor: M A, Bowman, O G, Simell, A B, Peck, J, Cornelius, R, Luchetta, Z, Look, N K, Maclaren, M A, Atkinson

Publikováno v: The Journal of pharmacology and experimental therapeutics. 279(2)

In vitro studies suggest that intra-islet nitric oxide production may contribute to the pathogenesis of autoimmune insulin-dependent diabetes mellitus. We tested whether aminoguanidine (AG), a competitive inhibitor of inducible nitric oxide synthase,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::91242331f229b2ba9ab5e27cb53f0266
https://pubmed.ncbi.nlm.nih.gov/8930185