In vitro selection and characterization of human immunodeficiency virus type 1 (HIV-1) isolates with reduced sensitivity to hydroxyethylamino sulfonamide inhibitors of HIV-1 aspartyl protease

Autor: O Futer, E E Blair, A B Cullinan, J. A. Partaledis, R E Myers, K Yamaguchi, B Maschera, C Falcione, S. Pazhanisamy, M. Tisdale

Human immunodeficiency virus type 1 (HIV-1) variants with reduced sensitivity to the hydroxyethylamino sulfonamide protease inhibitors VB-11,328 and VX-478 have been selected in vitro by two independent serial passage protocols with HIV-1 in CEM-SS a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15bb42c43e9463a0baffaa0308e0dea
https://europepmc.org/articles/PMC189353/

Charged surface residues of FKBP12 participate in formation of the FKBP12-FK506-calcineurin complex

Autor: R A, Aldape, O, Futer, M T, DeCenzo, B P, Jarrett, M A, Murcko, D J, Livingston

Publikováno v: The Journal of biological chemistry. 267(23)

The mechanism of FK506 immunosuppression has been proposed to proceed by formation of a tight-binding complex with the intracellular 12-kDa FK506-binding protein (FKBP12). The FK506-FKBP12 complex then acts as a specific high-affinity inhibitor of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::60837e53cc9a46bef35fe2c0816aa601
https://pubmed.ncbi.nlm.nih.gov/1379588

Mutants of Helicobacter pylori IMPDH: Kinetics and in silico Studies to Determine the Structural and Functional Role of Key Amino Acids.

Autor: Dilip, Haritha¹ (AUTHOR), Purushothaman, Gayathri² (AUTHOR), Sharma, Gaurav² (AUTHOR), Menon, Aishwarya² (AUTHOR), Thiruvenkatam, Vijay² (AUTHOR) vijay@iitgn.ac.in, Kirubakaran, Sivapriya¹ (AUTHOR) priyak@iitgn.ac.in

Publikováno v: Chemistry - An Asian Journal. 5/2/2022, Vol. 17 Issue 9, p1-7. 7p.

Three New Antibacterial Mycophenolic Acid Derivatives from the Marine-Derived Fungus Penicillium sp. HN-66.

Autor: Mo T; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, 571158, China., Qin Y; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, 571158, China., Zhang Y; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, 571158, China., Liang Y; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, 571158, China., Li X; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, 571158, China., Li W; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, 571158, China., Chen G; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, 571158, China.

Publikováno v: Chemistry & biodiversity [Chem Biodivers] 2024 Oct 07, pp. e202401657. Date of Electronic Publication: 2024 Oct 07.

Accelerating Vaccine Innovation for Emerging Infectious Diseases via Parallel Discovery.

Autor: Barberio, Joseph¹, Becraft, Jacob¹, Chaouch, Zied Ben², Bertsimas, Dimitris³, Kitada, Tasuku¹, Li, Michael L.⁴, Lo, Andrew W.⁵, Shi, Kevin¹, Xu, Qingyang⁶

Publikováno v: Entrepreneurship & Innovation Policy & the Economy. 2023, Vol. 2 Issue 1, p9-39. 31p.