The transcriptional landscape of Shh medulloblastoma

Autor: Patryk Skowron, Hamza Farooq, Florence M. G. Cavalli, A. Sorana Morrissy, Michelle Ly, Liam D. Hendrikse, Evan Y. Wang, Haig Djambazian, Helen Zhu, Karen L. Mungall, Quang M. Trinh, Tina Zheng, Shizhong Dai, Ana S. Guerreiro Stucklin, Maria C. Vladoiu, Vernon Fong, Borja L. Holgado, Carolina Nor, Xiaochong Wu, Diala Abd-Rabbo, Pierre Bérubé, Yu Chang Wang, Betty Luu, Raul A. Suarez, Avesta Rastan, Aaron H. Gillmor, John J. Y. Lee, Xiao Yun Zhang, Craig Daniels, Peter Dirks, David Malkin, Eric Bouffet, Uri Tabori, James Loukides, François P. Doz, Franck Bourdeaut, Olivier O. Delattre, Julien Masliah-Planchon, Olivier Ayrault, Seung-Ki Kim, David Meyronet, Wieslawa A. Grajkowska, Carlos G. Carlotti, Carmen de Torres, Jaume Mora, Charles G. Eberhart, Erwin G. Van Meir, Toshihiro Kumabe, Pim J. French, Johan M. Kros, Nada Jabado, Boleslaw Lach, Ian F. Pollack, Ronald L. Hamilton, Amulya A. Nageswara Rao, Caterina Giannini, James M. Olson, László Bognár, Almos Klekner, Karel Zitterbart, Joanna J. Phillips, Reid C. Thompson, Michael K. Cooper, Joshua B. Rubin, Linda M. Liau, Miklós Garami, Peter Hauser, Kay Ka Wai Li, Ho-Keung Ng, Wai Sang Poon, G. Yancey Gillespie, Jennifer A. Chan, Shin Jung, Roger E. McLendon, Eric M. Thompson, David Zagzag, Rajeev Vibhakar, Young Shin Ra, Maria Luisa Garre, Ulrich Schüller, Tomoko Shofuda, Claudia C. Faria, Enrique López-Aguilar, Gelareh Zadeh, Chi-Chung Hui, Vijay Ramaswamy, Swneke D. Bailey, Steven J. Jones, Andrew J. Mungall, Richard A. Moore, John A. Calarco, Lincoln D. Stein, Gary D. Bader, Jüri Reimand, Jiannis Ragoussis, William A. Weiss, Marco A. Marra, Hiromichi Suzuki, Michael D. Taylor

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Sonic Hedgehog medulloblastoma (Shh-MB) comprises four subtypes each with distinct clinical traits. Here the authors characterize the genome, transcriptome, and methylome of Shh-MB subtypes, revealing a complex fusion landscape and the molecular conv

Externí odkaz: https://doaj.org/article/091429a4162845e7a18371f487596c6f

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Staging of newly diagnosed Ewing sarcoma: Results of bone marrow aspiration and biopsy versus (18)FDG-PET/CT imaging for bone marrow involvement

Autor: A. Guinot, S. Tabone-Eglinger, V. Isnardi, H. Bahri, D. Surdez, O. Delattre, G. Pierron, M. Villemeur, E. Lapouble, M. Brahmi, A. Bouhamama, N. Corradini, Perrine Marec-Bérard

Publikováno v: European journal of cancer (Oxford, England : 1990). 179

Ewing sarcoma (ES) is an aggressive bone or extraosseous tumour with an unfavourable prognosis when bone marrow metastases are present at diagnosis. The gold standard diagnosis for bone marrow (BM) involvement is cytological and pathological analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5d669a6464043a5996d81fe6af86c0
https://pubmed.ncbi.nlm.nih.gov/36502618

Loss of SMARCB1 expression in colon carcinoma

Autor: Julien Taieb, Jean-François Emile, S. Melloul, P. Laurent Puig, D. Dansette, J. Masliah-Planchon, K. Le Malicot, Julien Edeline, O. Delattre, J.-F. Mosnier, J.-M. Gornet, Côme Lepage, Patrick Texereau

Publikováno v: Cancer Biomarkers
Cancer Biomarkers, IOS Press, 2020, 27 (3), pp.399-406. ⟨10.3233/CBM-190287⟩
Cancer Biomarkers, 2020, 27 (3), pp.399-406. ⟨10.3233/CBM-190287⟩

International audience; SMARCB1 is a tumor suppressor gene, which is part of SWI/SNF complex involved in transcriptional regulation. Recently, loss of SMARCB1 expression has been reported in gastrointestinal carcinomas. Our purpose was to evaluate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbc50db7ccc4cd0f2186ac6fbec8cce
https://doi.org/10.3233/cbm-190287