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Publikováno v:
Journal of Urban Ecology. 6
For the past 200 years, coyotes have steadily expanded their range eastward from the Midwestern USA. They have successfully colonized the contiguous landscape east of the Mississippi River and have been documented on Long Island, New York since 2009
Publikováno v:
Immunohematology. 32:29-31
Autor:
Reichel, O. Asher
Publikováno v:
Tradition: A Journal of Orthodox Jewish Thought, 1963 Apr 01. 5(2), 247-255.
Externí odkaz:
https://www.jstor.org/stable/23256129
Autor:
Michael P. Kozar, Xiannu Jin, Brandon S. Pybus, Victor Melendez, V. Collazo, Raul Olmeda, Constance O. Asher, N. Matlock, Thu Lan Luong, Dustin Carroll, Jason C. Sousa, Larry A. Walker, T. Logan, Sean R. Marcsisin
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 39(2)
The 8-aminoquinoline drug primaquine (PQ) is currently the only drug in use against the persistent malaria caused by the hypnozoite-forming strains P. vivax and P. ovale. However, despite decades of research, its complete metabolic profile is still p
Autor:
Lisa Xie, Constance O. Asher, ThuLan Luong, Qigui Li, Daniel A. Nichols, Clare E. Gutteridge, Gettayacamin Montip, Michael P. Kozar, Sean M. Curtis, Darshan S. Thota, Jing Zhang, Victor Melendez, Lucia Gerena
Publikováno v:
Pharmacology. 87(1-2)
4′-n-Butoxy-2,4-dimethoxy-chalcone (MBC) has been described as protecting mice from an otherwise lethal infection with Plasmodium yoelii when dosed orally at 50 mg/kg/dose, daily for 5 days. In contrast, we found that oral dosing of MBC at 640 mg/k
Autor:
Jason C. Sousa, Kirsten S. Smith, Michael P. Kozar, Damaris S. Diaz, David P. Jacobus, Constance O. Asher, Donald R. Skillman, Todd W Shearer, Guy A. Schiehser, Wilbur K. Milhous
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 36(2)
Phenoxypropoxybiguanides, such as PS-15, are antimalarial prodrugs analogous to the relationship of proguanil and its active metabolite cycloguanil. Unlike cycloguanil, however, WR99210, the active metabolite of PS-15, has retained in vitro potency a
Autor:
Kirsten S. Smith, Lucia Gerena, Charles A. DiTusa, Daniel A. Nichols, Sean M. Curtis, Joseph V. Vo, Apurba K. Bhattacharjee, Clare E. Gutteridge, Darshan S. Thota, Constance O. Asher, Gettayacamin Montip, Damaris S. Diaz
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(21)
Investigation of a series of 1-phenyl-3-aryl-2-propen-1-ones resulted in the identification of nine inhibitors with submicromolar efficacy against at least one Plasmodium falciparum strain in vitro. These inhibitors were inactive when given orally in
Autor:
N, Rahimi-Levene, A, Kornberg, G, Siegel, V, Morozov, E, Shinar, O, Asher, C, Levene, V, Yahalom
Publikováno v:
Immunohematology. 21(3)
The Drori (Dr(a)) antigen is one of the ten high-prevalence antigens of the Cromer blood system, which are carried on decayaccelerating factor (DAF, CD55). The Dr(a-) phenotype was first described in a 48-year-old Jewish woman from Bukhara. Her serum
Publikováno v:
Combinatorial chemistryhigh throughput screening. 8(1)
The high level of attrition of drugs in clinical development has led pharmaceutical companies to increase the efficiency of their lead identification and development through techniques such as combinatorial chemistry and high-throughput (HTP) screeni