Výsledky vyhledávání - "O A, Raevskiĭ"

Linear and nonlinear QSAR models of acute intravenous toxicity to mice for organic chemicals

Autor: A P Vorts, E A Liplavskaia, O A Raevskiĭ, A V Iarkov, O E Raevskaia

Publikováno v: Scopus-Elsevier

QSAR analysis of acute intravenous toxicity to mice for 68 monofunctional chemicals is presented. There compounds represents seven classes of organic chemicals: hydrocarbons (6 chemicals), alcohols (13), amides (22), amines (12), ethers (5), ketones

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7a09ca8925c7fb735584210aa7a961
https://doi.org/10.18097/pbmc20125804357

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Computer classification models on the relationship between chemical structures of compounds and drugs with their blood brain barrier penetration

Autor: O A, Raevskiĭ, S L, Solodova, O E, Raevskaia, Ia V, Liplavskiĭ, R M, Mannhold

Publikováno v: Biomeditsinskaya Khimiya. 58:246-256

Ability of drugs to cross blood-brain barrier (BBB) (BBB+ for BBB-penetrating and BBB- for non-penetrating compounds) is one of the most important properties of chemicals acting on the central nervous system (CNS). This work presents the results of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c0e3758429ec90ca75caa949c9061b
https://doi.org/10.18097/pbmc20125803246

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[Linear and nonlinear QSAR models of acute intravenous toxicity to mice for organic chemicals]

Autor: O A, Raevskiĭ, E A, Liplavskaia, A V, Iarkov, O E, Raevskaia, A P, Vorts

Publikováno v: Biomeditsinskaia khimiia. 58(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::45295523f3aec4636a85ac16470914f6
https://pubmed.ncbi.nlm.nih.gov/23413681

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[Quantitative dependence of structure-antiseizure activity in a series of macrocyclic compounds]

Autor: N V, Lukoianov, O A, Raevskiĭ

Publikováno v: Voprosy meditsinskoi khimii. 44(2)

In the present study we have further examined the influence of some structure parameters of macrocyclic polyethers upon their anticonvulsant activity in order to determine basic pharmacophore fragments. The anticonvulsant activity was studied experim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f1515b11f2c0579b22ae8428bfb4997
https://pubmed.ncbi.nlm.nih.gov/9634722

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[Inhibition of the dopamine reuptake system by analogs of the neurotoxic metabolite MPP (1-methyl-4-phenylpyridine). The structure-activity relationship]

Autor: S O, Bachurin, N V, Lukoianov, L N, Petrova, L S, Soliakov, S E, Tkachenko, O A, Raevskiĭ

Publikováno v: Doklady Akademii nauk. 346(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dfaa5786a3573ae707783fa125e24a42
https://pubmed.ncbi.nlm.nih.gov/8640134

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[Formation of models of the interaction between organophosphate compound structure and their ability to inhibit cholinesterase]

Autor: O A, Raevskiĭ, V V, Chistiakov, R S, Agabekian, A M, Sapegin, N S, Zefirov

Publikováno v: Bioorganicheskaia khimiia. 16(11)

On the basis of a discrete-regression model earlier proposed by the authors, computer modelling of relationships between structure of organophosphorous compounds and their anticholinesterase activity was carried out. Values of kinetic constants of re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff08869134f7f5db19bf67024dbe2459
https://pubmed.ncbi.nlm.nih.gov/2096825

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[Synthetic Ca++-dependent proton carrier]

Autor: N V, Lukoianov, O A, Raevskiĭ, A S, Shtepanek, T N, Kudria

Publikováno v: Biofizika. 31(1)

Influence of 1,5-(3,3'-dimethylphosphate)diphenoxy-3-oxapentane (DDOP) on conductivity (G) of bilayers of common fabbit brain lipids is studied. It has been found that DDOP increases the bilayer conductivity in the presence of Ca++ and Mg++ (G-maximu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0ff8962b1e71bbea8bf38acb76b4adcf
https://pubmed.ncbi.nlm.nih.gov/3006792

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