Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies

Autor: Ferguson, Mark WJ, Duncan, Jonathan, Bond, Jeremy, Bush, James, Durani, Piyush, So, Karen, Taylor, Lisa, Chantrey, Jonquille, Mason, Tracey, James, Gaynor, Laverty, Hugh, Occleston, Nick L, Sattar, Abdul, Ludlow, Anna, O'Kane, Sharon

Publikováno v: In The Lancet 2009 373(9671):1264-1274

New therapeutics for the prevention and reduction of scarring

Autor: Occleston, Nick L., O’Kane, Sharon, Goldspink, Nick, Ferguson, Mark W.J.

Publikováno v: In Drug Discovery Today 2008 13(21):973-981

Temporal and spatial expression of Pax9 and Sonic hedgehog during development of normal mouse palates and cleft palates in TGF- β3 null embryos

Autor: Sasaki, Yasunori, O’Kane, Sharon, Dixon, Jill, Dixon, Michael J., Ferguson, Mark W.J.

Publikováno v: In Archives of Oral Biology 2007 52(3):260-267

A synthetic gene increases TGFβ3 accumulation by 75-fold in tobacco chloroplasts enabling rapid purification and folding into a biologically active molecule

Autor: Gisby, Martin F., Mellors, Philip, Madesis, Panagiotis, Ellin, Marianne, Laverty, Hugh, O'Kane, Sharon, Ferguson, Mark W J, Day, Anil

Publikováno v: Gisby, M F, Mellors, P, Madesis, P, Ellin, M, Laverty, H, O'Kane, S, Ferguson, M W J & Day, A 2011, ' A synthetic gene increases TGFβ3 accumulation by 75-fold in tobacco chloroplasts enabling rapid purification and folding into a biologically active molecule ', Plant Biotechnology Journal, vol. 9, no. 5, pp. 618-628 . https://doi.org/10.1111/j.1467-7652.2011.00619.x

Human transforming growth factor-β3 (TGFβ3) is a new therapeutic protein used to reduce scarring during wound healing. The active molecule is a nonglycosylated, homodimer comprised of 13-kDa polypeptide chains linked by disulphide bonds. Expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::e95ac68182d665169fdb05bac27d9cf2
https://www.research.manchester.ac.uk/portal/en/publications/a-synthetic-gene-increases-tgf3-accumulation-by-75fold-in-tobacco-chloroplasts-enabling-rapid-purification-and-folding-into-a-biologically-active-molecule(b6244583-c7de-4f13-9492-a0939e386dcf).html

Therapeutic Improvement of Scarring: Mechanisms of Scarless and Scar-Forming Healing and Approaches to the Discovery of New Treatments

Autor: Occleston, Nick L., Metcalfe, Anthony D., Boanas, Adam, Burgoyne, Nicholas J., Nield, Kerry, O'Kane, Sharon, Ferguson, Mark W. J.

Publikováno v: Dermatology Research and Practice.

Scarring in the skin after trauma, surgery, burn or sports injury is a major medical problem, often resulting in loss of function, restriction of tissue movement and adverse psychological effects. Whilst various studies have utilised a range of model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=hindawi_publ::a663aca645a06da6a7372eb57320fa45