Monocyte NLRP3 inflammasome and interleukin-1β activation modulated by alpha-1 antitrypsin therapy in deficient individuals.

Autor: Gogoi D; Pulmonary Clinical Science, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Yu H; Department of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA., Casey M; Irish Centre for Genetic Lung Disease, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Baird R; Pulmonary Clinical Science, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Yusuf A; Pulmonary Clinical Science, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Forde L; Pulmonary Clinical Science, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., O' Brien ME; Irish Centre for Genetic Lung Disease, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., West JR; Division of Pulmonary, Critical Care and Sleep Medicine, J. Hillis Miller Health Science Center, University of Florida College of Medicine, Gainesville, Florida, USA., Flagg T; Division of Pulmonary, Critical Care and Sleep Medicine, J. Hillis Miller Health Science Center, University of Florida College of Medicine, Gainesville, Florida, USA., McElvaney NG; Irish Centre for Genetic Lung Disease, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Eden E; Icahn School of Medicine, Mount Sinai, New York, New York, USA., Mueller C; The Li Weibo Institute for Rare Diseases Research, Horae Gene Therapy Center, Worcester, MA, USA.; Department of Pediatrics, University of Massachusetts Chan Medical School, Worcester, MA, USA., Brantly ML; Division of Pulmonary, Critical Care and Sleep Medicine, J. Hillis Miller Health Science Center, University of Florida College of Medicine, Gainesville, Florida, USA., Geraghty P; Department of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA., Reeves EP; Pulmonary Clinical Science, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland emerreeves@rcsi.ie.

Publikováno v: Thorax [Thorax] 2024 Aug 19; Vol. 79 (9), pp. 822-833. Date of Electronic Publication: 2024 Aug 19.