Výsledky vyhledávání

Use of Conventional or Replicating Nucleic Acid-Based Vaccines and Recombinant Semliki Forest Virus-Derived Particles for the Induction of Immune Responses Against Hepatitis C Virus Core and E2 Antigens

Autor: I. Nakano, Christian Trepo, Peter Liljeström, C. Brinster, Y. Fukuda, Thomas F. Baumert, Nathalie Renard, A. Fournillier, Margaret Chen, Geneviève Inchauspe, O. Vidalin, Delphine Boucreux, Erik Depla

Publikováno v: Virology. 276(2):259-270

Replicating and nonreplicating nucleic acid-based vaccines as well as Semliki Forest-recombinant Viruses (rSFVs) were evaluated for the development of a vaccine against hepatitis C virus (HCV). Replicating SFV-DNA vaccines (pSFV) and rSFVs expressing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ed85d56b99fddb3c1f1549128748f5

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Modulation of immune responses to hepatitis C virus envelope E2 protein following injection of plasmid DNA using single or combined delivery routes

Autor: A. Fournillier, Isao Nakano, Geert Maertens, Ludmila Vitvitski, O. Vidalin, Christian Trepo, Erik Depla, Geneviève Inchauspe

Publikováno v: Hepatology. 28:237-244

Different delivery routes of plasmid DNA may result in the induction of differential humoral and cellular immunity. We have studied the influence of two main routes of plasmid injection, performed intramuscularly and intraepidermally using a gene gun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2372d28390df54ea1ebe5fb9fd0aba1c
https://doi.org/10.1002/hep.510280131

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In vitro inhibition of hepatitis C virus gene expression by chemically modified antisense oligodeoxynucleotides

Autor: J L Imbach, M E Major, C. Trepo, B Rayner, O. Vidalin, Geneviève Inchauspe

Publikováno v: Antimicrobial Agents and Chemotherapy. 40:2337-2344

We have explored different domains within the hepatitis C virus (HCV) 5' noncoding region as potential targets for inhibition of HCV translation by antisense oligodeoxynucleotides (ODNs). Inhibition assays were performed with two different cell-free

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de82b147ce0fcd4e641987443839c21a
https://doi.org/10.1128/aac.40.10.2337

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Flow cytometric analysis of peptide binding to major histocampatibility complex class I for hepatitis C virus core T-cell epitopes

Autor: Tilman Sauerbruch, Ulrich Spengler, Bettina Langhans, O. Vidalin, Wolfgang Kraas, Susann Schweitzer, Geneviève Inchauspe, Angelika M. Schneiders, Günther Jung

Publikováno v: Cytometry. 41(4)

Background/Methods To characterize the repertoire of T-cell epitopes on the hepatitis C virus (HCV) core protein, we studied major histocompatibility complex (MHC) class I binding of 75 decapeptides on 20 human B-cell lines and murine spleen cells us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88415495c4e105d34793459ae9d77189
https://pubmed.ncbi.nlm.nih.gov/11084612

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Expression of Noncovalent Hepatitis C Virus Envelope E1-E2 Complexes Is Not Required for the Induction of Antibodies with Neutralizing Properties following DNA Immunization

Autor: Christian Trepo, Geneviève Inchauspe, O. Vidalin, Peter Karayiannis, Geert Maertens, A. Fournillier, Erik Depla

Publikováno v: Scopus-Elsevier

Hepatitis C virus (HCV) is the major causative agent of transfusion-associated and community-acquired non-A, non-B hepatitis worldwide (6, 22). More than 70% of HCV infections become chronic, with a significant risk in 5 to 20% of cases of progressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6e4e4c0cb68006214896342518e312
https://europepmc.org/articles/PMC104276/

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Targeting of hepatitis C virus core protein for MHC I or MHC II presentation does not enhance induction of immune responses to DNA vaccination

Autor: Geneviève Inchauspe, O. Vidalin, Ulrich Spengler, Eiji Tanaka, Christian Trepo

Publikováno v: DNA and cell biology. 18(8)

We analyzed different vaccine approaches aimed at enhancing CD4(+)- and CD8(+)-dependent responses against hepatitis C virus (HCV) core antigen. Specific DNA vectors expressing various forms of the core in fusion with the ubiquitin or the lysosome-as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d611df08c2e81e7757971e1f76b8cb
https://pubmed.ncbi.nlm.nih.gov/10463057

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Specific detection of hepatitis C virus minus strand RNA in hematopoietic cells

Autor: C Trépo, M A Trabaud, O. Vidalin, M E Major, Hervé Lerat, F Berby, Geneviève Inchauspe

The presence of hepatitis C virus (HCV) negative strand RNA in extrahepatic compartments based on PCR detection assays has been suggested in many reports with a very heterologous detection rate (from 0 to 100%). In this study, we have analyzed the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8cf99e2967aa0e1e59c9682debd239
https://europepmc.org/articles/PMC507124/

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