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Evidence of a natural killer (NK) cell repertoire for (allo) antigen recognition: definition of five distinct NK-determined allospecificities in humans

Autor: L. Moretta, Gino Tripodi, Daniela Pende, C Di Donato, Alessandro Moretta, Anna Maria Orengo, Ermanno Ciccone, O Viale, John Guardiola

Publikováno v: The Journal of Experimental Medicine
Scopus-Elsevier

Previous studies indicated that CD3-CD16+ natural killer (NK) cells are capable of specific alloantigen recognition. Thus, alloreactive NK clones lysed normal allogeneic target cells (phytohemagglutinin [PHA] blasts) bearing the stimulating alloantig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75b5277c5ad79c04450842abbb95fee
http://europepmc.org/articles/PMC2119160

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Identification of four subsets of human CD3-CD16+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition

Autor: Daniela Pende, Gino Tripodi, Ermanno Ciccone, Giuseppe Tambussi, M Barbaresi, O Viale, Alessandro Moretta, Cristina Bottino, Anna Maria Orengo, Annalisa Merli

Publikováno v: The Journal of Experimental Medicine

In previous studies we identified a surface molecule (termed GL183) capable of mediating cell activation and selectively expressed by a subset of human CD3-CD16+ natural killer (NK) cells. In this study we analyzed whether other subset-specific funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d2f808d38a5f5431fdfe22b934f1d8
https://doi.org/10.1084/jem.172.6.1589

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Specific recognition of human CD3-CD16+ natural killer cells requires the expression of an autosomic recessive gene on target cells

Autor: Giuseppe Tambussi, Anna Longo, Ermanno Ciccone, Silvano Ferrini, Lorenzo Moretta, Alessandro Moretta, Roberto Biassoni, O Viale, Daniela Pende, John Guardiola

Publikováno v: The Journal of Experimental Medicine

We analyzed the recently defined ability of CD3-CD16+ cells to specifically recognize and lyse normal allogeneic target cells (PHA-induced blasts). The susceptibility to lysis by a given alloreactive natural killer (NK) clone ("1 anti-A") was express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b667fed09f655f48f642a44d1ca7b55
http://europepmc.org/articles/PMC2188160

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Control of B cell lymphoma recognition via natural killer inhibitory receptors implies a role for human Vgamma9/Vdelta2 T cells in tumor immunity

Autor: Eva Meuer, Pierre Coulie, Simon Rothenfußer, O Viale, Soldano Ferrone, Pierre van der Bruggen, Lorenzo Moretta, Daniela Pende, Thierry Boon, Didier Fradelizi, George Klein, Hans-Georg Rammensee, Paul Fisch, Sylvia Kock

The V gamma 9/V delta 2 T cell receptor (TCR) is expressed by most human gamma delta T cells, We show here that cytotoxic T lymphocytes of the V gamma 9/V delta 2 subset, but not of the V delta 1 subset of human gamma delta T cells, express natural k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd70936d6a63ea3c0f2eb651d14ff4fa
http://hdl.handle.net/11567/388169

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General role of HLA class I molecules in the protection of target cells from lysis by natural killer cells: evidence that the free heavy chains of class I molecules are not sufficient to mediate the protective effect

Autor: Massimo Vitale, Daniela Pende, Alessandro Moretta, C Di Donato, L. Nanni, Ermanno Ciccone, Simona Sivori, Lorenzo Moretta, O. Viale, A. Beretta

Publikováno v: International immunology. 7(3)

Some HLA-C alleles have been shown to exert a specific protective effect preventing target cells from lysis by groups of natural killer (NK) clones displaying a defined specificity. In this study, we analyzed whether class I-mediated protection is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aaec6ee39a24ee222e1de2bbc6c9766
https://pubmed.ncbi.nlm.nih.gov/7794819

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Antibodies to adhesion molecules inhibit the lytic function of MHC-unrestricted cytotoxic cells by preventing their activation

Autor: O Viale, Claudya Tenca, Walter Malorni, Daniela Zarcone, Carlo E. Grossi, Francesca Iosi, Ricciarda Galandrini, Giannamaria Cerruti, Andrea Velardi, Alessandro Moretta, Giuseppe Arancia

Publikováno v: Cellular immunology. 143(2)

We evaluated the effect of the antibodies to adhesion molecules CD2, CD11a/CD18 (LFA-1), and CD56 (N-CAM) on MHC-unrestricted cytotoxicity mediated by polyclonal NK cells and LAK cells or by CD3 + or CD3 − cytolytic cell clones against a panel of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c31c09342d5005d83fc8253ab6258d
https://pubmed.ncbi.nlm.nih.gov/1380897

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Specificity of Human T Lymphocytes Expressing a γ/δT Cell Antigen Receptor. Recognition of a Polymorphic Determinant of HLA Class I Molecules by a γ/δ+ Clone

Autor: Ermanno Ciccone, Daniela Pende, Alessandro Moretta, Lorenzo Moretta, O Viale, M. Malnati

Publikováno v: Function and Specificity of γ/δ T Cells ISBN: 9783642764943

In addition to the major T lymphocyte population, expressing surface receptors (TCR) for antigen/MHC composed of a disulphide-linked heterodimer (alpha/beta chains), a minor subset has recently been identified which expresses a different form (gamma/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72e35d139ebb8ac6c43c821246c99537
https://doi.org/10.1007/978-3-642-76492-9_31

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