Zobrazeno 1 - 10
of 65
pro vyhledávání: '"O, Tomé"'
Autor:
Sandra O. Tomé, Grigoria Tsaka, Alicja Ronisz, Simona Ospitalieri, Klara Gawor, Luis Aragão Gomes, Markus Otto, Christine A. F. von Arnim, Philip Van Damme, Ludo Van Den Bosch, Estifanos Ghebremedhin, Celeste Laureyssen, Kristel Sleegers, Rik Vandenberghe, Frederic Rousseau, Joost Schymkowitz, Dietmar Rudolf Thal
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-18 (2023)
Abstract Background Most Alzheimer’s Disease (AD) cases also exhibit limbic predominant age-related TDP-43 encephalopathy neuropathological changes (LATE-NC), besides amyloid-β plaques and neurofibrillary tangles (NFTs) containing hyperphosphoryla
Externí odkaz:
https://doaj.org/article/6d4c20f39ade433fbec5db315642c427
Autor:
Marta J. Koper, Sandra O. Tomé, Klara Gawor, Annelies Belet, Evelien Van Schoor, Jolien Schaeverbeke, Rik Vandenberghe, Mathieu Vandenbulcke, Estifanos Ghebremedhin, Markus Otto, Christine A. F. von Arnim, Sriram Balusu, Matthew B. Blaschko, Bart De Strooper, Dietmar Rudolf Thal
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-16 (2022)
Abstract It has become evident that Alzheimer’s Disease (AD) is not only linked to its hallmark lesions—amyloid plaques and neurofibrillary tangles (NFTs)—but also to other co-occurring pathologies. This may lead to synergistic effects of the r
Externí odkaz:
https://doaj.org/article/29e354dc5df743a1a8dfb1b935ec35c6
Autor:
Sandra O. Tomé, Rik Vandenberghe, Simona Ospitalieri, Evelien Van Schoor, Thomas Tousseyn, Markus Otto, Christine A. F. von Arnim, Dietmar Rudolf Thal
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-22 (2020)
Abstract The co-existence of multiple pathologies and proteins is a common feature in the brains of cognitively impaired elderly individuals. Transactive response DNA-binding protein (TDP-43) has been discovered to accumulate in limbic brain regions
Externí odkaz:
https://doaj.org/article/b65a58e10bb441299d9e03fef187ab0c
Autor:
Akila Weerasekera, Melissa Crabbé, Sandra O. Tomé, Willy Gsell, Diana Sima, Cindy Casteels, Tom Dresselaers, Christophe Deroose, Sabine Van Huffel, Dietmar Rudolf Thal, Philip Van Damme, Uwe Himmelreich
Publikováno v:
NeuroImage: Clinical, Vol 27, Iss , Pp 102327- (2020)
Currently TAR DNA binding protein 43 (TDP-43) pathology, underlying Amyotrophic Lateral Sclerosis (ALS), remains poorly understood which hinders both clinical diagnosis and drug discovery efforts. To better comprehend the disease pathophysiology, pos
Externí odkaz:
https://doaj.org/article/7b12c240f7ce41c28bf8719be368b7ab
Autor:
Dietmar Rudolf, Thal, Sandra O, Tomé
Publikováno v:
Brain Research Bulletin. 190:204-217
The tau protein (τ) is one of the two hallmark proteins of Alzheimer's disease (AD) together with the amyloid β protein (Aβ). In contrast to Aβ, abnormally phosphorylated τ (p-τ) can also be found in non-AD tauopathies. In AD, p-τ is the main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d4a5f8122aee077b85c3914b512de0
https://doi.org/10.1016/j.brainresbull.2022.10.006
https://doi.org/10.1016/j.brainresbull.2022.10.006
Akademický článek
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Autor:
Peter T. Nelson, Edward B. Lee, Matthew D. Cykowski, Irina Alafuzoff, Konstantinos Arfanakis, Johannes Attems, Carol Brayne, Maria M. Corrada, Brittany N. Dugger, Margaret E. Flanagan, Bernardino Ghetti, Lea T. Grinberg, Murray Grossman, Michel J. Grothe, Glenda M. Halliday, Masato Hasegawa, Suvi R. K. Hokkanen, Sally Hunter, Kurt Jellinger, Claudia H. Kawas, C. Dirk Keene, Naomi Kouri, Gabor G. Kovacs, James B. Leverenz, Caitlin S. Latimer, Ian R. Mackenzie, Qinwen Mao, Kirsty E. McAleese, Richard Merrick, Thomas J. Montine, Melissa E. Murray, Liisa Myllykangas, Sukriti Nag, Janna H. Neltner, Kathy L. Newell, Robert A. Rissman, Yuko Saito, S. Ahmad Sajjadi, Katherine E. Schwetye, Andrew F. Teich, Dietmar R. Thal, Sandra O. Tomé, Juan C. Troncoso, Shih-Hsiu J. Wang, Charles L. White, Thomas Wisniewski, Hyun-Sik Yang, Julie A. Schneider, Dennis W. Dickson, Manuela Neumann
Publikováno v:
Acta neuropathologica 145(2), 159-173 (2023). doi:10.1007/s00401-022-02524-2
An international consensus report in 2019 recommended a classification system for limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC). The suggested neuropathologic staging system and nomenclature have proven useful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72494332571ed755e236f6b2d683266
https://pubmed.ncbi.nlm.nih.gov/36512061
https://pubmed.ncbi.nlm.nih.gov/36512061
Autor:
Jolien Schaeverbeke, Sandra O. Tomé, Alicja Ronisz, Simona Ospitalieri, Christine A. F. von Arnim, Markus Otto, Rik Vandenberghe, Dietmar Rudolf Thal
Publikováno v:
Alzheimer'sdementia : the journal of the Alzheimer's AssociationREFERENCES.
INTRODUCTION: Imaging studies indicated basal forebrain reduction in primary progressive aphasia (PPA), which might be a candidate marker for cholinergic treatment. Nucleus basalis of Meynert (nbM) neuronal loss has been reported, but a systematic qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6268455c92f36686b621a299bffecc9
https://pubmed.ncbi.nlm.nih.gov/36170544
https://pubmed.ncbi.nlm.nih.gov/36170544
Autor:
Patrik Verstreken, Dietmar Rudolf Thal, Rik Vandenberghe, Thomas Tousseyn, Luis Aragão Gomes, Christine A. F. von Arnim, Diego Lopez-Sanmartin, Sandra O. Tomé, Mathieu Vandenbulcke, Valerie Uytterhoeven
Publikováno v:
Acta Neuropathologica
In Alzheimer's disease (AD), tau-protein undergoes a multi-step process involving the transition from a natively unfolded monomer to large, aggregated structures such as neurofibrillary tangles (NFTs). However, it is not yet clear which events initia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5a0c6a4cb81d6086908acd22dacdc1
https://doi.org/10.1007/s00401-020-02251-6
https://doi.org/10.1007/s00401-020-02251-6
Autor:
Evelien Van Schoor, Simona Ospitalieri, Sebastiaan Moonen, Sandra O. Tomé, Alicja Ronisz, Orkun Ok, Jochen Weishaupt, Albert C. Ludolph, Philip Van Damme, Ludo Van Den Bosch, Dietmar Rudolf Thal
Publikováno v:
Acta neuropathologica 144(3), 393-411 (2022). doi:10.1007/s00401-022-02466-9
Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motor neurons in the motor cortex, brainstem, and spinal cord. Although ALS is considered a motor neuron disorder, neuroinflammation also plays an important role. Recent evid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3c53395a7b4e2afdc364d08dc754e8
https://pubmed.ncbi.nlm.nih.gov/35867112
https://pubmed.ncbi.nlm.nih.gov/35867112