Zobrazeno 1 - 10
of 264
pro vyhledávání: '"O, Tjernberg"'
Autor:
Anders Sandberg, Ernesto Berenjeno-Correa, Rosa Crespo Rodriguez, Michael Axenhus, Sophia Schedin Weiss, Kevin Batenburg, Jeroen J. M. Hoozemans, Lars O. Tjernberg, Wiep Scheper
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-20 (2022)
Abstract Background In Alzheimer’s disease (AD), amyloid-β 1–42 (Aβ42) neurotoxicity stems mostly from its soluble oligomeric aggregates. Studies of such aggregates have been hampered by the lack of oligomer-specific research tools and their in
Externí odkaz:
https://doaj.org/article/cee0908148f64f599e9891ba7768079f
Autor:
Hazal Haytural, Rui Benfeitas, Sophia Schedin-Weiss, Erika Bereczki, Melinda Rezeli, Richard D. Unwin, Xusheng Wang, Eric B. Dammer, Erik C. B. Johnson, Nicholas T. Seyfried, Bengt Winblad, Betty M. Tijms, Pieter Jelle Visser, Susanne Frykman, Lars O. Tjernberg
Publikováno v:
Scientific Data, Vol 8, Iss 1, Pp 1-11 (2021)
Abstract Mass spectrometry (MS)-based proteomics is a powerful tool to explore pathogenic changes of a disease in an unbiased manner and has been used extensively in Alzheimer disease (AD) research. Here, by performing a meta-analysis of high-quality
Externí odkaz:
https://doaj.org/article/d189ee05892c4b5e8df9e6a2031f9246
Autor:
Jolanta L. Lundgren, Lina Vandermeulen, Anna Sandebring-Matton, Saheeb Ahmed, Bengt Winblad, Monica Di Luca, Lars O. Tjernberg, Elena Marcello, Susanne Frykman
Publikováno v:
BMC Neuroscience, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background Synaptic degeneration and accumulation of amyloid β-peptides (Aβ) are hallmarks of the Alzheimer diseased brain. Aβ is synaptotoxic and produced by sequential cleavage of the amyloid precursor protein (APP) by the β-secretase
Externí odkaz:
https://doaj.org/article/015fd95e45944b449a0bb53f742f6273
Autor:
Anna Sandebring-Matton, Michael Axenhus, Nenad Bogdanovic, Bengt Winblad, Sophia Schedin-Weiss, Per Nilsson, Lars O. Tjernberg
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Novel insights on proteins involved in Alzheimer’s disease (AD) are needed. Since multiple cell types and matrix components are altered in AD, bulk analysis of brain tissue maybe difficult to interpret. In the current study, we isolated pyramidal c
Externí odkaz:
https://doaj.org/article/b8e169d732ac4e29afd84eac3f2589c9
Autor:
C. E. Matt, D. Sutter, A. M. Cook, Y. Sassa, M. Månsson, O. Tjernberg, L. Das, M. Horio, D. Destraz, C. G. Fatuzzo, K. Hauser, M. Shi, M. Kobayashi, V. N. Strocov, T. Schmitt, P. Dudin, M. Hoesch, S. Pyon, T. Takayama, H. Takagi, O. J. Lipscombe, S. M. Hayden, T. Kurosawa, N. Momono, M. Oda, T. Neupert, J. Chang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
The essential physics of cuprate superconductors is often described by single-band models. Here, Matt et al. report direct observation of a two-band electronic structure in La-based cuprates.
Externí odkaz:
https://doaj.org/article/8e98210fe47b42c2af77538e100afa11
Publikováno v:
Biomedicines, Vol 9, Iss 7, p 801 (2021)
Alzheimer’s disease (AD) is the most common type of dementia, contributing to 60–80% of cases. It is a neurodegenerative disease that usually starts symptomless in the first two to three decades and then propagates into a long-term, irreversible
Externí odkaz:
https://doaj.org/article/efa78d8b969c414188eaf504fc6db385
Autor:
Sophia Schedin-Weiss, Mitsuhiro Inoue, Lenka Hromadkova, Yasuhiro Teranishi, Natsuko Goto Yamamoto, Birgitta Wiehager, Nenad Bogdanovic, Bengt Winblad, Anna Sandebring-Matton, Susanne Frykman, Lars O. Tjernberg
Publikováno v:
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-19 (2017)
Abstract Background Increased levels of the pathogenic amyloid β-peptide (Aβ), released from its precursor by the transmembrane protease γ-secretase, are found in Alzheimer disease (AD) brains. Interestingly, monoamine oxidase B (MAO-B) activity i
Externí odkaz:
https://doaj.org/article/e013012247bd498c9c9baac88e3a9855
Autor:
Hazal Haytural, Jolanta L. Lundgren, Tansu B. Köse, Tomàs Jordà-Siquier, Marinela Kalcheva, Mohammed Seed Ahmed, Bengt Winblad, Erik Sundström, Gaël Barthet, Lars O. Tjernberg, Susanne Frykman
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
The use of human post-mortem brain material is of great value when investigating which pathological mechanisms occur in human brain, and to avoid translational problems which have for example been evident when translating animal research into Alzheim
Externí odkaz:
https://doaj.org/article/e2b58afc23234ecf8a2fb5d7b085315d
Publikováno v:
Biomolecules, Vol 11, Iss 6, p 858 (2021)
Proteomics—large-scale studies of proteins—has over the last decade gained an enormous interest for studies aimed at revealing proteins and pathways involved in disease. To fully understand biological and pathological processes it is crucial to a
Externí odkaz:
https://doaj.org/article/2abeed48cf2c4d58b5f2e348ba52179f
Autor:
Johanna Wanngren, Patricia Lara, Karin Öjemalm, Silvia Maioli, Nasim Moradi, Lu Chen, Lars O. Tjernberg, Johan Lundkvist, IngMarie Nilsson, Helena Karlström
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 393-406 (2014)
The enzyme complex γ-secretase generates amyloid β-peptide (Aβ), a 37–43-residue peptide associated with Alzheimer disease (AD). Mutations in presenilin 1 (PS1), the catalytical subunit of γ-secretase, result in familial AD (FAD). A unifying th
Externí odkaz:
https://doaj.org/article/d575a72492234136bf2c6d4143b2d91f