Zobrazeno 1 - 10
of 419
pro vyhledávání: '"O, Stutman"'
Publikováno v:
The Journal of Immunology. 156:2062-2067
T cells may discriminate between stimuli in a variety of ways, including the presence of cytokines or other costimulatory signals, the type of Ag (peptide, superantigen, or allorecognition), or the magnitude of the signal through the TCR. We have use
Autor:
O, Stutman
Publikováno v:
Medicina. 60(1)
Immunology is a young science, much younger than MEDICINA, since its modern biological foundations were established only in the 70s-80s with the definition of the T and B cell receptors. In spite of its relative youth, many key basic biological knowl
Autor:
S C, Shih, O, Stutman
Publikováno v:
Cancer research. 56(7)
To determine if tumor necrosis factor (TNF)-mediated apoptosis affects cells at defined stages of the cell cycle, WEHI-164/2F (WEHI) cells were synchronized at G0-G1 after 3-day cultures in medium containing RPMI 1640 and 0.5% FCS (RPMI-0.5% FCS). Th
Autor:
T, Hernández-Caselles, O, Stutman
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 151(8)
Murine rTNF produces at least three effects on mouse thymocytes in vitro: 1) Is a modest co-stimulator of proliferation with low PHA-P doses. 2) Has a bi-directional interaction with rIL-6-depending on PHA concentration: at low PHA (5 to 10 microgram
Autor:
E C, Lattime, O, Stutman
Publikováno v:
Natural immunity. 11(1)
Based on their enhanced susceptibility to tumor necrosis factor (TNF), sublines of the BALB/c fibrosarcoma WEHI-164 are more and more frequently being used to measure levels of TNF in cell-free supernatants. In studies aimed at characterizing the cyt
Publikováno v:
The Journal of Immunology. 133:45-51
Bulk culture and limiting dilution analysis (LDA) were used to follow the ontogeny of the tolerant state in CBA/ HT6T6 mice neonatally tolerized to allogeneic histocompatibility antigens. Advantage was taken of the fact that the lymph nodes (LN) of y
Autor:
C E Calkins, O Stutman
Publikováno v:
The Journal of Experimental Medicine
The activity of suppressor cells from spleens of mice of varying ages was assessed by their addition to cultures of normal or SRBC immune spleen cells together with a challenge of SRBC. 1-wk and adult spleen cells were highly suppressive of the secon
Autor:
R A Miller, O Stutman
Publikováno v:
The Journal of Immunology. 133:2925-2932
Mice depleted of T cells by thymectomy, lethal irradiation, and reconstitution with Thy-1-depleted syngeneic bone marrow were given graded doses of splenic T cells to see whether post-thymic cells had the ability to regenerate immune function in thes
Publikováno v:
The Journal of Immunology. 130:2075-2078
The study of cell surface antigens has accelerated in the few years since the advent of hybridoma technology to the point where many dozens of such markers have now been described. The functional heterogeneity of post-thymic T cells in the immune res
Publikováno v:
The Journal of Immunology. 128:480-485
In the murine syngeneic mixed lymphocyte response (SMLR), the co-culture of nylon wool-nonadherent spleen cells or young (4 to 6-day-old) thymocytes with syngeneic nylon wool-adherent adult spleen cells, results in proliferation and Interleukin 2 (IL