Zobrazeno 1 - 10
of 171
pro vyhledávání: '"O, Mazzoni"'
Autor:
Congyi Lu, Görkem Garipler, Chao Dai, Timothy Roush, Jose Salome-Correa, Alex Martin, Noa Liscovitch-Brauer, Esteban O. Mazzoni, Neville E. Sanjana
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Neurogenins are proneural transcription factors required to specify neuronal identity. Their overexpression in human pluripotent stem cells rapidly produces cortical-like neurons with spiking activity and, because of this, they have been wid
Externí odkaz:
https://doaj.org/article/ad8ef460a1204559942a2bc78de5322f
Autor:
Begüm Aydin, Michael Sierk, Mireia Moreno-Estelles, Link Tejavibulya, Nikathan Kumar, Nuria Flames, Shaun Mahony, Esteban O. Mazzoni
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Neuronal programming by forced expression of transcription factors (TFs) holds promise for clinical applications of regenerative medicine. However, the mechanisms by which TFs coordinate their activities on the genome and control distinct neuronal fa
Externí odkaz:
https://doaj.org/article/7f1cb8a0d28b411c88f0b01e3a7958e8
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-25 (2021)
Abstract Background Transcription factor (TF) binding specificity is determined via a complex interplay between the transcription factor’s DNA binding preference and cell type-specific chromatin environments. The chromatin features that correlate w
Externí odkaz:
https://doaj.org/article/c6e3cec6127c4286bb8ea182719b614a
Publikováno v:
ACS Omega, Vol 5, Iss 25, Pp 15537-15546 (2020)
Externí odkaz:
https://doaj.org/article/93df5560f0ac4e52aa6f42d0915e5a42
Autor:
Ayana Sawai, Sarah Pfennig, Milica Bulajić, Alexander Miller, Alireza Khodadadi-Jamayran, Esteban O Mazzoni, Jeremy S Dasen
Publikováno v:
eLife, Vol 11 (2022)
Polycomb repressive complexes (PRCs) 1 and 2 maintain stable cellular memories of early fate decisions by establishing heritable patterns of gene repression. PRCs repress transcription through histone modifications and chromatin compaction, but their
Externí odkaz:
https://doaj.org/article/ae50bea8eb184126ac6cad25c8e5f861
Autor:
Alessandra Zappulo, David van den Bruck, Camilla Ciolli Mattioli, Vedran Franke, Koshi Imami, Erik McShane, Mireia Moreno-Estelles, Lorenzo Calviello, Andrei Filipchyk, Esteban Peguero-Sanchez, Thomas Müller, Andrew Woehler, Carmen Birchmeier, Enrique Merino, Nikolaus Rajewsky, Uwe Ohler, Esteban O. Mazzoni, Matthias Selbach, Altuna Akalin, Marina Chekulaeva
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Subcellular localization of RNAs and proteins is important for polarized cells such as neurons. Here the authors differentiate mouse embryonic stem cells into neurons, and analyze the local transcriptome, proteome, and translated transcriptome in the
Externí odkaz:
https://doaj.org/article/78855abe544f4175b8a66cdc42637e8a
Publikováno v:
Cell Reports, Vol 16, Iss 4, Pp 907-916 (2016)
The motor neuron progenitor domain in the ventral spinal cord gives rise to multiple subtypes of motor neurons and glial cells. Here, we examine whether progenitors found in this domain are multipotent and which signals contribute to their cell-type-
Externí odkaz:
https://doaj.org/article/26367d2994024c198cba90098e181501
Autor:
Yi Fu, Pedro P. Rocha, Vincent M. Luo, Ramya Raviram, Yan Deng, Esteban O. Mazzoni, Jane A. Skok
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
The ability to target Cas9 to specific genomic loci offers the potential for applications beyond genome editing. Here the authors use deactivated Cas9 and chimeric guide RNAs to visualise individual repetitive loci in living cells.
Externí odkaz:
https://doaj.org/article/635bafc37e314ac384163cddf0d14810
Autor:
Julie R. Perlin, William J. Anderson, Sina Bartfeld, Anna Couturier, Yvanka de Soysa, R. Scott Hawley, Ping Hu, Yuin-Han Loh, Lolitika Mandal, Zubin Master, Alysson R. Muotri, Eugenia Piddini, Jose M. Polo, Esteban O. Mazzoni
Publikováno v:
Stem cell reports, vol 18, iss 2
The rapidly evolving stem cell field puts much stress on developing educational resources. The ISSCR Education Committee has created a flexible stem cell syllabus rooted in core concepts to facilitate stem cell literacy. The free syllabus will be upd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057cac52cdda03625f79a26fa6844747
https://escholarship.org/uc/item/6488f3b0
https://escholarship.org/uc/item/6488f3b0
Autor:
Sudarshan Pinglay, Milica Bulajić, Dylan P. Rahe, Emily Huang, Ran Brosh, Nicholas E. Mamrak, Benjamin R. King, Sergei German, John A. Cadley, Lila Rieber, Nicole Easo, Timothée Lionnet, Shaun Mahony, Matthew T. Maurano, Liam J. Holt, Esteban O. Mazzoni, Jef D. Boeke
Publikováno v:
Science
INTRODUCTION: Despite an ever-expanding catalog of noncoding elements that are implicated in the control of mammalian gene expression, how the regulatory input from multiple elements is integrated across a genomic neighborhood has remained largely un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7772d22daf61c45f770cf5e49e7233
https://doi.org/10.1126/science.abk2820
https://doi.org/10.1126/science.abk2820