Zobrazeno 1 - 10 of 407 pro vyhledávání: '"O, Kaufmann"'
1
Akademický článek
ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries
Autor: Jan O. Kaufmann, Julia Brangsch, Avan Kader, Jessica Saatz, Dilyana B. Mangarova, Martin Zacharias, Wolfgang E. Kempf, Timm Schwaar, Marco Ponader, Lisa C. Adams, Jana Möckel, Rene M. Botnar, Matthias Taupitz, Lars Mägdefessel, Heike Traub, Bernd Hamm, Michael G. Weller, Marcus R. Makowski
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
New biomarkers are required to improve the assessment of aortic wall integrity and risk of rupture. Here the authors report the development of an imaging probe for ADAMTS4, which they test in an abdominal aortic aneurysm mouse model and show in vivo
Externí odkaz: https://doaj.org/article/50cc7240c78643138e6d36a92e15e4de
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2
Akademický článek
Noninvasive imaging of vascular permeability to predict the risk of rupture in abdominal aortic aneurysms using an albumin-binding probe
Autor: Lisa C. Adams, Julia Brangsch, Carolin Reimann, Jan O. Kaufmann, Kristin Nowak, Rebecca Buchholz, Uwe Karst, Rene M. Botnar, Bernd Hamm, Marcus R. Makowski
Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Abdominal aortic aneurysm (AAA) remains a fatal disease. Its development encompasses a complex interplay between hemodynamic stimuli on and changes in the arterial wall. Currently available biomarkers fail to predict the risk of AAA rupture
Externí odkaz: https://doaj.org/article/610a4cd45a534f3e9c8facea371c27ed
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3
Akademický článek
Dual-probe molecular MRI for the in vivo characterization of atherosclerosis in a mouse model: Simultaneous assessment of plaque inflammation and extracellular-matrix remodeling
Autor: Carolin Reimann, Julia Brangsch, Jan O. Kaufmann, Lisa C. Adams, David C. Onthank, Christa Thöne-Reineke, Simon P. Robinson, Bernd Hamm, Rene M. Botnar, Marcus R. Makowski
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Molecular MRI is a promising in-vivo modality to detect and quantify morphological and molecular vessel-wall changes in atherosclerosis. The combination of different molecular biomarkers may improve the risk stratification of patients. This
Externí odkaz: https://doaj.org/article/67ea2411ff59459594a387f07d91f49e
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4
Akademický článek
Imaging groundwater infiltration dynamics in the karst vadose zone with long-term ERT monitoring
Autor: A. Watlet, O. Kaufmann, A. Triantafyllou, A. Poulain, J. E. Chambers, P. I. Meldrum, P. B. Wilkinson, V. Hallet, Y. Quinif, M. Van Ruymbeke, M. Van Camp
Publikováno v: Hydrology and Earth System Sciences, Vol 22, Pp 1563-1592 (2018)
Water infiltration and recharge processes in karst systems are complex and difficult to measure with conventional hydrological methods. In particular, temporarily saturated groundwater reservoirs hosted in the vadose zone can play a buffering role
Externí odkaz: https://doaj.org/article/ad0751e02db4484e88c5d72baf0a3846
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5
Akademický článek
Visualization and Quantification of the Extracellular Matrix in Prostate Cancer Using an Elastin Specific Molecular Probe
Autor: Avan Kader, Julia Brangsch, Carolin Reimann, Jan O. Kaufmann, Dilyana B. Mangarova, Jana Moeckel, Lisa C. Adams, Jing Zhao, Jessica Saatz, Heike Traub, Rebecca Buchholz, Uwe Karst, Bernd Hamm, Marcus R. Makowski
Publikováno v: Biology, Vol 10, Iss 11, p 1217 (2021)
Human prostate cancer (PCa) is a type of malignancy and one of the most frequently diagnosed cancers in men. Elastin is an important component of the extracellular matrix and is involved in the structure and organization of prostate tissue. The prese
Externí odkaz: https://doaj.org/article/4f93d5471fdf409b963d4d318a415b80
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6
Akademický článek
Assessment of Albumin ECM Accumulation and Inflammation as Novel In Vivo Diagnostic Targets for Multi-Target MR Imaging
Autor: Jana Möckel, Julia Brangsch, Carolin Reimann, Jan O. Kaufmann, Ingolf Sack, Dilyana B. Mangarova, Avan Kader, Matthias Taupitz, Lisa C. Adams, Sarah Keller, Antje Ludwig, Bernd Hamm, Rene M. Botnar, Marcus R. Makowski
Publikováno v: Biology, Vol 10, Iss 10, p 964 (2021)
Atherosclerosis is a progressive inflammatory vascular disease characterized by endothelial dysfunction and plaque burden. Extracellular matrix (ECM)-associated plasma proteins play an important role in disease development. Our magnetic resonance ima
Externí odkaz: https://doaj.org/article/1459b56f3180452e8e417056a67258b8
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8
Akademický článek
Author Correction: Simultaneous molecular MRI of extracellular matrix collagen and inflammatory activity to predict abdominal aortic aneurysm rupture
Autor: Lisa C. Adams, Julia Brangsch, Carolin Reimann, Jan O. Kaufmann, Rebecca Buchholz, Uwe Karst, Rene M. Botnar, Bernd Hamm, Marcus R. Makowski
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz: https://doaj.org/article/92ddcab7a2b34444a845143a424256f2
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10
Akademický článek
Molecular MR Imaging of Prostate Cancer
Autor: Avan Kader, Julia Brangsch, Jan O. Kaufmann, Jing Zhao, Dilyana B. Mangarova, Jana Moeckel, Lisa C. Adams, Ingolf Sack, Matthias Taupitz, Bernd Hamm, Marcus R. Makowski
Publikováno v: Biomedicines, Vol 9, Iss 1, p 1 (2020)
This review summarizes recent developments regarding molecular imaging markers for magnetic resonance imaging (MRI) of prostate cancer (PCa). Currently, the clinical standard includes MR imaging using unspecific gadolinium-based contrast agents. Spec
Externí odkaz: https://doaj.org/article/ea07f88d5fe346d9999d72dc19842b4a
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