Výsledky vyhledávání

Increased expression of c-jun, but not retinoic acid receptor beta, is associated with F9 teratocarcinoma stem cell differentiation induced by polyamine depletion

Autor: J L, Bjersing, A, Brorsson, O, Heby

Publikováno v: Journal of cellular biochemistry. 67(3)

alpha-Difluoromethylornithine (DFMO), an enzyme-activated irreversible inhibitor of ornithine decarboxylase, and all-trans-retinoic acid (RA) are known to induce F9 teratocarcinoma stem cell differentiation. Both compounds induce the formation of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4234525d0a367dc605aaaa689bd6fabe
https://pubmed.ncbi.nlm.nih.gov/9361192

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Development of resistance to hydroxyurea during treatment of human myelogenous leukemia K562 cells with alpha-difluoromethylornithine as a result of coamplification of genes for ornithine decarboxylase and ribonucleotide reductase R2 subunit

Autor: A, Ask, L, Persson, A, Rehnholm, L, Frostesjö, I, Holm, O, Heby

Publikováno v: Cancer research. 53(21)

alpha-Difluoromethylornithine (DFMO), an enzyme-activated irreversible inhibitor of ornithine decarboxylase (ODC), was used to select two very highly drug-resistant cell lines, designated K562-DFMOr and V79-DFMOr. Both DFMO-resistant cell lines exhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f1bf09fabb4fa3c4d8e8d7ba1e1266cb
https://pubmed.ncbi.nlm.nih.gov/8221660

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Akademický článek

Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagasâ disease, and leishmaniasis.

Autor: O. Heby, L. Persson, M. Rentala

Publikováno v: Amino Acids; Aug2007, Vol. 33 Issue 2, p359-366, 8p

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Changes in polyamine metabolism in WI38 cells stimulated to proliferate

Autor: Laurence J. Marton, O. Heby, L. Zardi, David H. Russell, Renato Baserga

Publikováno v: Experimental Cell Research. 90:8-14

Quiescent confluent monolayers of WI38 human diploid fibroblasts were stimulated to proliferate by replacement of the exhausted medium with fresh medium containing 10% fetal calf serum. The cellular content of the polyamines, putrescine, spermidine,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05dc2df3ce549d17c5cabadc7a2b13fd
https://doi.org/10.1016/0014-4827(75)90350-x

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Interactions of polyamines and acid macromolecules observed in double diffusion in gel experiments

Autor: I.P.S. Agrell, O. Heby

Publikováno v: Experimental Cell Research. 50:668-671

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d513b5feb652f9c1ce709dbdc32fb3a6
https://doi.org/10.1016/0014-4827(68)90433-3

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Urinary polyamine excretion during the menstrual cycle

Autor: S Rosén, S Osterberg, O Heby

Publikováno v: Clinical Chemistry. 24:769-771

Urinary polyamines were measured by a fluorometric thin-layer chromatographic technique in samples collected daily throughout a single menstrual cycle by each of 13 healthy women. Polyamine excretion fluctuated considerably, but excretion of putresci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c9f6a9d4f1b2552a9fa86ed75dbb477
https://doi.org/10.1093/clinchem/24.5.769

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A method for the determination of polyamines in cerebrospinal fluid

Autor: L J, Marton, O, Heby, C B, Wilson, P L, Lee

Publikováno v: FEBS Letters. (1-2):305-307

1. Introduction Data are rapidly accumulating which indicate that the determination of polyamine levels in physiological fluids may prove useful in diagnosing cancer and in evaluating the efficacy of various cancer treatment modes [l-3]. Methods are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5b13a3ffedb96545c29c9cb12f26ab

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Localization of ornithine decarboxylase in mutant CHO cells that overproduce the enzyme. Differences between the intracellular distribution of monospecific ornithine decarboxylase antibodies and radiolabeled alpha-difluoromethylornithine

Autor: S, Anehus, H, Emanuelsson, L, Persson, F, Sundler, I E, Scheffler, O, Heby

Publikováno v: European journal of cell biology. 35(2)

The intracellular localization of ornithine decarboxylase (ODC), a key enzyme in polyamine synthesis and cell growth, is a matter of present debate. Using two independent methods of analysis, we have attempted to determine the actual distribution of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::65205bd7da10981e504a85c841743731
https://pubmed.ncbi.nlm.nih.gov/6440787

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Effects of methylglyoxal-bis(guanylhydrazone) on polyamine metabolism in spleens of mice with disseminated L1210 lymphoid leukemia

Autor: O, Heby, D H, Russell

Publikováno v: Cancer research. 34(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed776d9afc2288991a993c7b63a0f02b
https://pubmed.ncbi.nlm.nih.gov/4815000

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Nuclear ornithine decarboxylase. Electron microscope autoradiographic identification of the active enzyme using alpha-[5-3H]difluoromethylornithine

Autor: H, Emanuelsson, O, Heby

Publikováno v: European journal of cell biology. 30(2)

alpha-Difluoromethylornithine (DFMO) is an enzyme-activated irreversible inhibitor of ornithine decarboxylase, that forms a covalent bond with the active enzyme. The highly selective binding of tritium-labeled DFMO to ornithine decarboxylase in vivo,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::55ca01fbbcd51dc1eb7289629e5495c4
https://pubmed.ncbi.nlm.nih.gov/11596505

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