Randomised, open-label, multicentric phase III trial to evaluate the safety and efficacy of palbociclib in combination with endocrine therapy, guided by ESR1 mutation monitoring in oestrogen receptor-positive, HER2-negative metastatic breast cancer patients: study design of PADA-1

Autor: C Cheneau, S Barthier, J Lemonnier, Fabrice Andre, C Dubot, L Teixeira, A Escande, T De La Motte Rouge, T Petit, L Arnould, Laurent Arnould, Suzette Delaloge, Jerome Lemonnier, A Marti, L Stefani, F Berger, C Levy, P Barthelemy, S Nguyen, M Gardner, A Lortholary, François-Clément Bidard, J Plaza, L Joly, Thibault de la Motte Rouge, F Andre, I Bièche, C Alleaume, R Sabatier, B Lucas, Ivan Bieche, O Derbel, L Venat-Bouvet, F Del Piano, Florian Clatot, Anne-Claire Hardy-Bessard, Frédérique Berger, Margaux Marce, Thomas Bachelot, Anne Pradines, Jean-Luc Canon, Sandrine Marques, M Achille, H Ammarguellat, O Arsene, T Bachelot, C Bernard-Marty, F-C Bidard, N Bonichon-Lamichhane, N Bonnin, R Bouaita, A Boudrant, V-A Brunel, C Chakiba, F Clatot, F Dalenc, A De Gramont, L Deiana, C Delbaldo, V Delecroix, H Desclos, V D'Hondt, N Dohollou, J-M Ferrero, C Foa, J-S Frenel, C Garnier Tixidre, D Genet, O Gisserot, M Gozy, C Greilsamer, J Grenier, F Guinet, A-C Hardy-Bessard, J-P Jacquin, E Lachaier, S Ladoire, A-P Laurenty, R Le Scodan, N Leduc, E Legouffe, C Levache, F Lorchel, N Marques, J Medioni, A Melis, D Mille, D Mollon, L Moreau, I Moullet, M-A Mouret-Reynier, A Najem, H Orfeuvre, J-F Paitel, B Pistilli, C Riedl, P Soulie, D Spaeth, F Trouboul, C Valmar, H Vegas, A Zannetti, FC Bidard, S Delaloge, A Pradines, JL Canon, S Marques

Publikováno v: BMJ Open, Vol 12, Iss 3 (2022)

Introduction The combination of a CDK4/6 inhibitor with an aromatase inhibitor (AI) has recently become the gold standard for AI-sensitive first line treatment of oestrogen receptor-positive (ER+) HER2-negative (HER2−) advanced breast cancer. Howev

Externí odkaz: https://doaj.org/article/8faf6bbc845f4ceeb90674dd08e198da

[Acquired, non-amyloid related factor X deficiency: A first case associated with atypical chronic lymphocytic leukemia and literature review]

Autor: L, Boudin, M, Patient, E, Roméo, J-S, Bladé, O, Gisserot, J-P, de Jauréguiberry

Publikováno v: La Revue de medecine interne. 38(7)

Acquired factor X deficiency is in most cases associated with AL amyloidosis. Acquired non-amyloid related factor X deficiency (DNAA-FX) has been exceptionally reported in the literature.We report the first case of acquired, non-amyloid related facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::549c409ca07984b5436e3176e81ae042
https://pubmed.ncbi.nlm.nih.gov/28110969

Principes de traitement des tumeurs métastatiques

Autor: É. ROMÉO, O. GISSEROT, J.-P. DE JAURÉGUIBERRY, J.-S. BLADÉ

Publikováno v: Médecine et Armées Vol. 39 No. 1. :25-32

Les tumeurs germinales métastatiques affectent majoritairement les jeunes adultes. Ces tumeurs sont de bon pronostic avec, approximativement, un taux de guérison global de 80 % après trois à quatre cycles de chimiothérapie associant la bléomyci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32d1f4d3c5c398573e6767fc2b4d0ae5
https://doi.org/10.17184/eac.6429

Comprehensive geriatric assessment predicts tolerance to chemotherapy and survival in elderly patients with advanced ovarian carcinoma: a GINECO study

Autor: Gilles Freyer, Nicole Tubiana-Mathieu, Eric Pujade-Lauraine, Bettina Weber, Jean-Philippe Jacquin, O. Gisserot, J.-F. Geay, G. Ganem, S. Touzet, Judith L. Provencal

Publikováno v: Annals of Oncology. 16:1795-1800

Background: Data from prospective clinical trials are needed to better define standards of care in elderly patients with advanced ovarian carcinoma and to demonstrate the interest of Comprehensive Geriatric Assessment (CGA) in this fragile and hetero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abcfea208bc2a8d90e4b4bb40f39e37f
https://doi.org/10.1093/annonc/mdi368

Maladie de Crohn cutanée métastatique. À propos d'une observation

Autor: F. Carsuzaa, J. P. Terrier, O Gisserot, F Marrot, M Lombard

Publikováno v: La Revue de Médecine Interne. 18:477-480

Resume Les auteurs rapportent l'observation d'un homme de 54 ans presentant une eruption papulonodulaire de la face. Il est suivi pour une maladie de Crohn connue depuis 36 ans, asymptomatique lors de l'apparition des signes cutanes. La biopsie d'une

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::213b0c2c4929e4d62652705fa365392c
https://doi.org/10.1016/s0248-8663(97)80620-0