Zobrazeno 1 - 10
of 22
pro vyhledávání: '"O'shea Morgan Welzel"'
Autor:
Manav Korpal, Nathalie Rioux, O'shea Morgan Welzel, Pete Smith, Sherri Smith, Markus Warmuth, Sudeep Prajapati, Zheng Guo Zhu
Publikováno v:
Cancer Chemotherapy and Pharmacology. 83:151-160
H3B-6545, a novel selective estrogen receptor (ER)α covalent antagonist (SERCA) which inactivates both wild-type and mutant ERα, is in clinical development for the treatment of metastatic breast cancer. Preclinical studies were conducted to charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5eb3b5b1915edbafb3d21dde20c76a0
https://doi.org/10.1007/s00280-018-3716-3
https://doi.org/10.1007/s00280-018-3716-3
Autor:
Sean Eckley, Markus Warmuth, Ping Zhu, Deepti Banka, Zhenhua J. Wu, Nicholas A. Larsen, Sudeep Prajapati, Ricardo Ribas, Ming-Hong Hao, Pavan Kumar, Pete Smith, Michael J. Wick, Kiran Aithal, Crystal Mackenzie, John D. Norris, Sasirekha Sivakumar, V. Subramanian, Tuong-Vi Nguyen, Lihua Yu, Sean Irwin, Andrew Hart, Craig Furman, Alyssa Moriarty, Amy Kim, Benjamin Caleb, O'shea Morgan Welzel, Craig Karr, Sunil Pancholi, Frédéric H. Vaillancourt, Silvia Buonamici, Manav Korpal, Namita Kumar, Weidong G. Lai, Diana Melchers, Peter Fekkes, René Houtman, Lesley-Ann Martin, Xiaoling Puyang, Victoria Rimkunas, Michael Thomas, Amy Siu, Reynolds Dominic, Sujatha Rajagopalan, Suzanne E. Wardell, John Wang, Jaya Julie Joshi, Zheng Guo Zhu, David M. Bolduc, Nathalie Rioux, Subhasree Das, Sergei Agoulnik, Shihua Yao, Galina Kuznetsov
Publikováno v:
Cancer Discovery. 8:1176-1193
Mutations in estrogen receptor alpha (ERα) that confer resistance to existing classes of endocrine therapies are detected in up to 30% of patients who have relapsed during endocrine treatments. Because a significant proportion of therapy-resistant b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0120259fcf7ad9215e86543a6ac089d0
https://doi.org/10.1158/2159-8290.cd-17-1229
https://doi.org/10.1158/2159-8290.cd-17-1229
Autor:
Sean Irwin, Guo-Zhu Zheng, Sherri Smith, Craig Furman, Deepti Banka, Nathalie Rioux, Victoria Rimkunas, J Norris, Prashant Kumar, Nicholas A. Larsen, Y Yu, Anand Selvaraj, Sergei Agoulnik, Craig Karr, Andrew Hart, T Bowser, Lorna Helen Mitchell, Crystal MacKenzie, Huilan Yao, Pete Smith, Tarek Sahmoud, Peter Fekkes, Jiayi Wu, T-V Nguyen, Zhaojie Zhang, Frédéric H. Vaillancourt, Betty Chan, Mike Thomas, Benjamin Caleb, O'shea Morgan Welzel, Manav Korpal, Markus Warmuth, Ping Zhu, S Wardell, Amy K. Kim, Galina Kuznetsov, Sean Eckley, Allison Davis, Sudeep Prajapati, Jun Wang, Ming-Hong Hao, V. Subramanian, Naresh Kumar, Xiaoling Puyang, Lihua Yu, Jaya Julie Joshi, Reynolds Dominic, G W Lai
Publikováno v:
Cancer Research. 78:P1-10
Mutations in estrogen receptor alpha (ERα) are detected in up to 30% of breast cancer patients who have relapsed during endocrine therapy. ERα mutations functionally confer resistance to existing classes of endocrine therapies, likely through gaini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07d855e8c12d90a391ebb18e38827bdf
https://doi.org/10.1158/1538-7445.sabcs17-p1-10-08
https://doi.org/10.1158/1538-7445.sabcs17-p1-10-08
Autor:
Markus Warmuth, Manav Korpal, Deepti Banka, Peter Fekkes, Pavan Kumar, Andrew Hart, Lihua Yu, Ping Zhu, Lorna Helen Mitchell, Joyce Yang, W. George Lai, Amy Kim, Craig Karr, Pete Smith, Tarek Sahmoud, Xiaoling Puyang, Sherri Smith, Mike Thomas, Benjamin Caleb, O'shea Morgan Welzel, Victoria Rimkunas, Huilan Yao, Sean Eckley, Allison Davis, Silvia Buonamici, Crystal MacKenzie, V. Subramanian, Jeremy Wu, Zheng Guo Zhu, Christopher Rowbottom, Reynolds Dominic, Nicholas A. Larsen, Nathalie Rioux, Sean Irwin, Craig Furman
Publikováno v:
Cancer Research. 77:DDT01-04
Mutations in the estrogen receptor (ER) are detected in up to 30% of patients that initially respond but subsequently relaps to anti-endocrine therapies. ERα mutations, likely through constitutively activating ERα, can functionally confer resistanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71b5b0fa7e9d8e6795b2dcf66171548d
https://doi.org/10.1158/1538-7445.am2017-ddt01-04
https://doi.org/10.1158/1538-7445.am2017-ddt01-04
Autor:
Huiming Zhang, Linda Lee, Sudeep Prajapati, Betty Chan, Kazunobu Kira, Mingde Shan, Laura Corson, Ming-Hong Hao, Kuo-Ming Wu, O'shea Morgan Welzel, Yoshiharu Mizui, Samantha Perino, John Wang, Eun Sun Park, Lisa A. Marcaurelle, Marta Nevalainen, Arai Kenzo, Guo-Zhu Zheng, Markus Warmuth, Lihua Yu, Atsushi Endo, Jason T. Lowe, Xiang Liu, Baudouin Gerard, Pete Smith, Tivitmahaisoon Parcharee, Craig Karr, Silvia Buonamici, Keaney Gregg F, Tuoping Luo
Publikováno v:
Organic Letters. 16:5560-5563
A total synthesis of the natural product 6-deoxypladienolide D (1) has been achieved. Two noteworthy attributes of the synthesis are (1) a late-stage allylic oxidation which proceeds with full chemo-, regio-, and diastereoselectivity and (2) the deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60a255bfd7796bff2bb3d4c8b6a0b4b
https://doi.org/10.1021/ol502556c
https://doi.org/10.1021/ol502556c
Autor:
Sherri Smith, Pete Smith, Ming-Hung Hao, John Wang, Nathalie Rioux, Sudeep Prajapati, Federico Colombo, O'shea Morgan Welzel, Darrel Nix, Markus Warmuth, Manav Korpal
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9db8e4d4b00c803aa828c50ef4bff278
https://doi.org/10.1016/j.dmpk.2018.09.093
https://doi.org/10.1016/j.dmpk.2018.09.093
Autor:
Lakshmi B. Akella, Eric N. Jacobsen, Etienne J. Donckele, O'shea Morgan Welzel, Baudouin Gerard, Sarathy Kesavan, Lisa A. Marcaurelle, Hao Xu
Publikováno v:
ACS Combinatorial Science. 14:621-630
A 2328-membered library of 2,3,4-trisubstituted tetrahydroquinolines was produced using a combination of solution- and solid-phase synthesis techniques. A tetrahydroquinoline (THQ) scaffold was prepared via an asymmetric Povarov reaction using cooper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d73ca79941da9077348174648e4593
https://doi.org/10.1021/co300098v
https://doi.org/10.1021/co300098v
Autor:
Jeremy R. Duvall, Sarathy Kesavan, Michael Foley, Byung-Chul Suh, O'shea Morgan Welzel, Jean-Charles Marie, Bérénice C. Lemercier, Bhaumik A. Pandya, Sivaraman Dandapani, Baudouin Gerard, Tiffanie Murillo, Lisa A. Marcaurelle, Mark E. Fitzgerald, Lakshmi B. Akella, Michael Dombrowski, Diane Hamann, Jason T. Lowe, Maurice D. Lee
Publikováno v:
The Journal of organic chemistry. 78(11)
A diversity-oriented synthesis (DOS) strategy was developed for the synthesis of stereochemically diverse fused-ring systems containing a pyran moiety. Each scaffold contains an amine and methyl ester for further diversification via amine capping and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e15888091458d338d6459327e2afda
https://pubmed.ncbi.nlm.nih.gov/23692141
https://pubmed.ncbi.nlm.nih.gov/23692141
Autor:
Mingde Shan, Samantha Perino, Zheng Guo Zhu, Linda Lee, Pete Smith, Eun Sun Park, Marta Nevalainen, Huiming Zhang, Kazunobu Kira, Markus Warmuth, Arai Kenzo, Atsushi Endo, Baudouin Gerard, Xiang Liu, Tivitmahaisoon Parcharee, Keaney Gregg F, Silvia Buonamici, Lihua Yu, Jason T. Lowe, John Wang, Craig Karr, Tuoping Luo, Laura Corson, Kuo-Ming Wu, Betty Chan, Lisa A. Marcaurelle, Sudeep Prajapati, Ming-Hong Hao, Yoshiharu Mizui, O'shea Morgan Welzel
Publikováno v:
Cancer Research. 75:5564-5564
Hotspot mutations in several components of the spliceosome have been reported in various hematological (CLL, MDS, etc.) and solid tumor (melanoma, pancreatic, etc.) malignancies. SF3B1 is a component of the U2 snRNP complex of the spliceosome and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4b3f513df548c8caf875d85523e2a8a
https://doi.org/10.1158/1538-7445.am2015-5564
https://doi.org/10.1158/1538-7445.am2015-5564
Autor:
Lakshmi B. Akella, Etienne J. Donckele, Lisa A. Marcaurelle, Baudouin Gerard, O'shea Morgan Welzel, Hao Xu, Sarathy Kesavan, Eric N. Jacobsen
Publikováno v:
ACS Combinatorial Science. 16:46-46
Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library Baudouin Gerard, Morgan Welzel O’Shea, Etienne Donckele, Sarathy Kesavan, Lakshmi B. Akella, Hao Xu, Eric N. Jacobsen, and Lisa A. Marcaurelle* ACS Comb. Sci. 2012, 14, 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05eefda263f1288f9097201ac68fb31
https://doi.org/10.1021/co400123x
https://doi.org/10.1021/co400123x