Zobrazeno 1 - 10
of 11
pro vyhledávání: '"O'connell James Philip"'
Autor:
Tim Bourne, Prashant Mori, Rachel Davis, Tom Ceska, Alastair D. G. Lawson, O'connell James Philip, Bruce Carrington, John Robert Porter, David A. Fox, Carlos Martinez-Fleites, David McMillan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Tumour necrosis factor (TNF) is a trimeric protein which signals through two membrane receptors, TNFR1 and TNFR2. Previously, we identified small molecules that inhibit human TNF by stabilising a distorted trimer and reduce the number of receptors bo
Autor:
Alison Maloney, John Robert Porter, O'connell James Philip, Bruce Carrington, Alison Turner, David A. Fox, Tom Ceska, David McMillan, Anthony Scott-Tucker, Antje Schmidt, Daniel John Lightwood, Tim Bourne, Rebecca Munro, Alastair D. G. Lawson, Elizabeth S. Hickford
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications
Nature Communications
We have recently described the development of a series of small-molecule inhibitors of human tumour necrosis factor (TNF) that stabilise an open, asymmetric, signalling-deficient form of the soluble TNF trimer. Here, we describe the generation, chara
Publikováno v:
Bluntzer, M T J, O'Connell, J, Baker, T S, Michel, J & Hulme, A N 2020, ' Designing stapled peptides to inhibit protein-protein interactions: An analysis of successes in a rapidly changing field ', Peptide Science . https://doi.org/10.1002/pep2.24191
Two decades after their discovery, stapled peptide methodologies have evolved to a point where they can be used with confidence to generate therapeutic leads. Research groups across the world are testing innovative methodologies for their design, wit
Autor:
David A. Fox, Bruce Carrington, Rachel Davis, Alex Vugler, John Robert Porter, Timothy John Norman, Benjamin P. Cossins, Boris Kroeplien, Fabien Claude Lecomte, David McMillan, Alastair D. G. Lawson, Alex B. Burgin, Tim Bourne, Stephen Edward Rapecki, Tom Ceska, O'connell James Philip, Alison Maloney, Tracy Arakaki
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Tumour necrosis factor (TNF) is a cytokine belonging to a family of trimeric proteins; it has been shown to be a key mediator in autoimmune diseases such as rheumatoid arthritis and Crohn’s disease. While TNF is the target of several successful bio
4-Pyridin-5-yl-2-(3,4,5-trimethoxyphenylamino)pyrimidines: Potent and selective inhibitors of ZAP 70
Autor:
Peter G Davis, Mark James Batchelor, Martin J. Perry, Tom Carabbe, Daniel Berg, Jeremy Martin Davis, O'connell James Philip, Martin Clive Hutchings, David Festus Charles Moffat, James E. Johnson, Jean Delgado, Richard J. Martin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:3351-3356
Activation of the tyrosine kinase ZAP 70 has been shown to be crucial to the transduction of the T-cell receptor signalling pathway, which leads ultimately to proliferation, cytokine gene expression and T-cell effector functions. A series of 2-phenyl
Autor:
Stanley W. Botchway, Rahul B. Yadav, Rodger A. Allen, Pierre Burgos, Valentina Iadevaia, Christopher D. Stubbs, O'connell James Philip, Anthony W. Parker, Christopher G. Proud, Ananya Jeshtadi
Publikováno v:
BMC Cell Biology, Vol 14, Iss 1, p 3 (2013)
BMC Cell Biology
BMC Cell Biology
Background The mammalian target of rapamycin (mTOR) signalling pathway has a key role in cellular regulation and several diseases. While it is thought that Rheb GTPase regulates mTOR, acting immediately upstream, while raptor is immediately downstrea
Autor:
Byron A. Boyce, Nigel Robert Arnold Beeley, J. Richard Morphy, Andrew T. Millican, Joanna Leonard, Barbara Mason, Kenneth Millar, John Robert Porter, O'connell James Philip
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2747-2752
A series of zinc binding groups was introduced into a pseudopeptide sequence containing aromatic groups in the P1′ position in order to obtain selective inhibitors of gelatinase-A. Carboxylic acid and phosphonic acid groups provided the most potent
Autor:
Kenneth Millar, Joanna Leonard, O'connell James Philip, Andrew T. Millican, Byron A. Boyce, J. Richard Morphy, Barbara Mason, John Robert Porter, Nigel Robert Arnold Beeley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2741-2746
A series of hydroxamic acid derivatives were prepared. By introducing aromatic substituents at the P1′ and P3′ positions highly potent gelatinase-A inhibitors, which possess a high degree of selectivity over collagenase and stromelysin, were obta
Autor:
Peter J. Connolly, Michael Reuman, Dana L. Johnson, Martin J. Perry, Gilles Bignan, Anne Foley, Angel R. Fuentes-Pesquera, David Moffatt, O'connell James Philip, Tuman Robert W, Susan J. Hazel, Stuart Emanuel, Jennifer A. Seamon, Beth Hollister, Rodger A. Allen, Cheryl Napier, Rose Tominovich, Steven A. Middleton, Mark James Batchelor, Robert H. Gruninger, Linda K. Jolliffe, Michael R. D'Andrea
Publikováno v:
Molecular pharmacology. 66(3)
Inhibition of angiogenesis may have wide use in the treatment of cancer; however, this approach alone will not cause tumor regression but may only slow the growth of solid tumors. The clinical potential of antiangiogenic agents may be increased by co
Autor:
O'Connell, James Philip
Processes leading to the in vitro activation of progelatinase-A, progelatinase-B and procollagenase were examined. Progelatinase-A can be activated by treatment with 4-aminophenyl mercuric acetate or by matrilysin and collagenase. The former induces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30169b3ae2deed7ae2d5d2e88611fe3c