Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy

Autor: Campiani, Giuseppe, Khan, Tuhina, Ulivieri, Cristina, Staiano, Leopoldo, Papulino, Chiara, Magnano, Stefania, Nathwani, Seema, Ramunno, Anna, Lucena-Agell, Daniel, Relitti, Nicola, Federico, Stefano, Pozzetti, Luca, Carullo, Gabriele, Casagni, Alice, Brogi, Simone, Vanni, Francesca, Galatello, Paola, Ghanim, Magda, McCabe, Niamh, Lamponi, Stefania, Valoti, Massimo, Ibrahim, Ola, O'Sullivan, Jeffrey, Turkington, Richard, Kelly, Vincent P., VanWemmel, Ruben, Díaz, J. Fernando, Gemma, Sandra, Zisterer, Daniela, Altucci, Lucia, De Matteis, Maria Antonietta, Butini, Stefania, Benedetti, Rosaria

Publikováno v: In European Journal of Medicinal Chemistry 5 May 2022 235

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Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation

Autor: Francesca Vanni, Niamh H McCabe, Stefania Lamponi, Cristina Ulivieri, Federica Sarno, Fulvio Saccoccia, Sandra Gemma, Giulia Chemi, David W. Christianson, Ola Ibrahim, Margherita Brindisi, Simone Brogi, Giovina Ruberti, Stefano Federico, Manfred Jung, Giuseppe Campiani, Nicola Relitti, Vincent P. Kelly, Daniela M. Zisterer, Stefania Butini, Richard C. Turkington, Antonella Di Costanzo, Patricia Hannon Barroeta, Rebecca Amet, Lucia Altucci, Magda Ghanim, Jeff O'Sullivan, Alessandro Grillo, Jeremy D. Osko, A Prasanth Saraswati, Daniel Herp

Publikováno v: Saraswati, A P, Relitti, N, Brindisi, M, Osko, J D, Chemi, G, Federico, S, Grillo, A, Brogi, S, McCabe, N H, Turkington, R C, Ibrahim, O, O'Sullivan, J, Lamponi, S, Ghanim, M, Kelly, V P, Zisterer, D, Amet, R, Hannon Barroeta, P, Vanni, F, Ulivieri, C, Herp, D, Sarno, F, Di Costanzo, A, Saccoccia, F, Ruberti, G, Jung, M, Altucci, L, Gemma, S, Butini, S, Christianson, D W & Campiani, G 2020, ' Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation ', ACS MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 11, pp. 2268-2276 . https://doi.org/10.1021/acsmedchemlett.0c00395
ACS Med Chem Lett
ACS medicinal chemistry letters (2020). doi:10.1021/acsmedchemlett.0c00395
info:cnr-pdr/source/autori:A Prasanth Saraswati 1, Nicola Relitti 1, Margherita Brindisi 1, Jeremy D Osko 2, Giulia Chemi 1, Stefano Federico 1, Alessandro Grillo 1, Simone Brogi 3, Niamh H McCabe 4, Richard C Turkington 4, Ola Ibrahim 5, Jeffrey O'Sullivan 5, Stefania Lamponi 1, Magda Ghanim 6, Vincent P Kelly 6, Daniela Zisterer 6, Rebecca Amet 6, Patricia Hannon Barroeta 6, Francesca Vanni 7, Cristina Ulivieri 7, Daniel Herp 8, Federica Sarno 9, Antonella Di Costanzo 9, Fulvio Saccoccia 10, Giovina Ruberti 10, Manfred Jung 8, Lucia Altucci 9, Sandra Gemma 1, Stefania Butini 1, David W Christianson 2, Giuseppe Campiani/titolo:Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation/doi:10.1021%2Facsmedchemlett.0c00395/rivista:ACS medicinal chemistry letters/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
ACS Medicinal Chemistry Letters

[Image: see text] Histone deacetylase inhibitors (HDACi) have emerged as promising therapeutics for the treatment of neurodegeneration, cancer, and rare disorders. Herein, we report the development of a series of spiroindoline-based HDAC6 isoform-sel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdda0b9bb58feac3ff72ae889a7ab41
https://pure.qub.ac.uk/en/publications/spiroindolinecapped-selective-hdac6-inhibitors-design-synthesis-structural-analysis-and-biological-evaluation(5bed77f3-2eb8-4bef-8802-360242d740c1).html