Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue.

Autor: Dhavale DD; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA., Barclay AM; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA., Borcik CG; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA., Basore K; Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO, 63110, USA., Berthold DA; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA., Gordon IR; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA., Liu J; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA., Milchberg MH; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA., O'Shea JY; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA., Rau MJ; Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO, 63110, USA., Smith Z; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA., Sen S; Theoretical and Computational Biophysics Group, NIH Resource for Macromolecular Modeling and Visualization, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA., Summers B; Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO, 63110, USA., Smith J; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA., Warmuth OA; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA., Perrin RJ; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Perlmutter JS; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Radiology, Neuroscience, Physical Therapy and Occupational Therapy, Washington University School of Medicine, St. Louis, MO, 63110, USA., Chen Q; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA., Fitzpatrick JAJ; Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO, 63110, USA., Schwieters CD; Computational Biomolecular Magnetic Resonance Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Tajkhorshid E; Theoretical and Computational Biophysics Group, NIH Resource for Macromolecular Modeling and Visualization, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA., Rienstra CM; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. crienstra@wisc.edu.; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA. crienstra@wisc.edu.; Morgridge Institute for Research, University of Wisconsin-Madison, Madison, WI, 53706, USA. crienstra@wisc.edu.; National Magnetic Resonance Facility at Madison, University of Wisconsin-Madison, Madison, WI, 53706, USA. crienstra@wisc.edu., Kotzbauer PT; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA. kotzbauerp@wustl.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Mar 29; Vol. 15 (1), pp. 2750. Date of Electronic Publication: 2024 Mar 29.