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Akademický článek

Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset.

Autor: Hanlon MM; Molecular Rheumatology, School of Medicine, Trinity College Dublin, Dublin, Ireland.; Centre for Arthritis and Rheumatic Diseases, St. Vincent's University Hospital, University College Dublin, Dublin, Ireland., Smith CM; School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland., Canavan M; Molecular Rheumatology, School of Medicine, Trinity College Dublin, Dublin, Ireland.; Centre for Arthritis and Rheumatic Diseases, St. Vincent's University Hospital, University College Dublin, Dublin, Ireland.; Translational Immunopathology, School of Biochemistry and Immunology and School of Medicine, Trinity College Dublin, Dublin, Ireland., Neto NGB; Department of Mechanical and Manufacturing Engineering, Trinity Biomedical Sciences Institute, Dublin, Ireland., Song Q; Immunology and Discovery Sciences, Janssen Research and Development, Spring House, PA, USA., Lewis MJ; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London and Barts NIHR BRC and Barts Health NHS Trust, London, UK., O'Rourke AM; Molecular Rheumatology, School of Medicine, Trinity College Dublin, Dublin, Ireland.; Centre for Arthritis and Rheumatic Diseases, St. Vincent's University Hospital, University College Dublin, Dublin, Ireland.; Translational Immunopathology, School of Biochemistry and Immunology and School of Medicine, Trinity College Dublin, Dublin, Ireland., Tynan O; Molecular Rheumatology, School of Medicine, Trinity College Dublin, Dublin, Ireland.; Centre for Arthritis and Rheumatic Diseases, St. Vincent's University Hospital, University College Dublin, Dublin, Ireland., Barker BE; Molecular Rheumatology, School of Medicine, Trinity College Dublin, Dublin, Ireland.; Centre for Arthritis and Rheumatic Diseases, St. Vincent's University Hospital, University College Dublin, Dublin, Ireland., Gallagher P; Centre for Arthritis and Rheumatic Diseases, St. Vincent's University Hospital, University College Dublin, Dublin, Ireland., Mullan R; Department of Rheumatology, Adelaide and Meath Hospital, Dublin, Ireland., Hurson C; Department of Orthopaedics, St. Vincent's University Hospital, Dublin, Ireland., Moran B; School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland., Monaghan MG; Department of Mechanical and Manufacturing Engineering, Trinity Biomedical Sciences Institute, Dublin, Ireland., Pitzalis C; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London and Barts NIHR BRC and Barts Health NHS Trust, London, UK.; Department of Biomedical Sciences, Humanitas University and Humanitas Research Hospital, Milan, Italy., Fletcher JM; School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Nagpal S; Immunology and Discovery Sciences, Janssen Research and Development, Spring House, PA, USA., Veale DJ; Centre for Arthritis and Rheumatic Diseases, St. Vincent's University Hospital, University College Dublin, Dublin, Ireland., Fearon U; Molecular Rheumatology, School of Medicine, Trinity College Dublin, Dublin, Ireland.; Centre for Arthritis and Rheumatic Diseases, St. Vincent's University Hospital, University College Dublin, Dublin, Ireland.

Publikováno v: Science advances [Sci Adv] 2024 Sep 27; Vol. 10 (39), pp. eadj1252. Date of Electronic Publication: 2024 Sep 25.

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Akademický článek

Effect of Immunosuppression on the Immune Response to SARS-CoV-2 Infection and Vaccination.

Autor: Leacy EJ; Trinity Kidney Centre, Trinity Translational Medicine Institute, School of Medicine, Trinity College Dublin, D08 W9RT Dublin, Ireland., Teh JW; Department of Nephrology, Galway University Hospital, H91 YR71 Galway, Ireland., O'Rourke AM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, D02 R590 Dublin, Ireland., Brady G; Trinity Kidney Centre, Trinity Translational Medicine Institute, School of Medicine, Trinity College Dublin, D08 W9RT Dublin, Ireland., Gargan S; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, D08 W9RT Dublin, Ireland., Conlon N; Department of Immunology, St. James's Hospital, D08 NHY1 Dublin, Ireland., Scott J; Trinity Kidney Centre, Trinity Translational Medicine Institute, School of Medicine, Trinity College Dublin, D08 W9RT Dublin, Ireland., Dunne J; Department of Immunology, St. James's Hospital, D08 NHY1 Dublin, Ireland., Phelan T; Trinity Kidney Centre, Trinity Translational Medicine Institute, School of Medicine, Trinity College Dublin, D08 W9RT Dublin, Ireland., Griffin MD; Department of Nephrology, Galway University Hospital, H91 YR71 Galway, Ireland.; Regenerative Medicine Institute (REMEDI) at CÚRAM SFI Research Centre for Medical Devices, School of Medicine, University of Galway, H91 TK33 Galway, Ireland., Power J; Vasculitis Ireland Awareness, Belfast & Dublin, Ireland., Mooney A; Department of Immunology, St. James's Hospital, D08 NHY1 Dublin, Ireland., Naughton A; Department of Immunology, St. James's Hospital, D08 NHY1 Dublin, Ireland., Kiersey R; Department of Immunology, St. James's Hospital, D08 NHY1 Dublin, Ireland., Gardiner M; Department of Immunology, St. James's Hospital, D08 NHY1 Dublin, Ireland., O'Brien C; Department of Immunology, St. James's Hospital, D08 NHY1 Dublin, Ireland., Mullan R; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, D08 W9RT Dublin, Ireland.; Department of Rheumatology, Tallaght University Hospital, D24 NR0A Dublin, Ireland., Flood R; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, D08 W9RT Dublin, Ireland.; Department of Rheumatology, Tallaght University Hospital, D24 NR0A Dublin, Ireland., Clarkson M; Department of Nephrology, Cork University Hospital, T12 DC4A Cork, Ireland., Townsend L; Department of Infectious Diseases, St. James's Hospital, D08 NHY1 Dublin, Ireland., O'Shaughnessy M; Department of Nephrology, Galway University Hospital, H91 YR71 Galway, Ireland.; Department of Nephrology, Cork University Hospital, T12 DC4A Cork, Ireland., Dyer AH; Discipline of Medical Gerontology, School of Medicine, Trinity College Dublin, D08 W9RT Dublin, Ireland., Moran B; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, D02 R590 Dublin, Ireland., Fletcher JM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, D02 R590 Dublin, Ireland., Zgaga L; Department of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, D02 PN40 Dublin, Ireland., Little MA; Trinity Kidney Centre, Trinity Translational Medicine Institute, School of Medicine, Trinity College Dublin, D08 W9RT Dublin, Ireland.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 May 11; Vol. 25 (10). Date of Electronic Publication: 2024 May 11.

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Akademický článek

Metformin has anti-inflammatory effects and induces immunometabolic reprogramming via multiple mechanisms in hidradenitis suppurativa.

Autor: Petrasca A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Hambly R; Department of Dermatology, St. Vincent's University Hospital, Dublin, Ireland.; Charles Institute of Dermatology, Dublin, Ireland., Kearney N; Department of Dermatology, St. Vincent's University Hospital, Dublin, Ireland.; Charles Institute of Dermatology, Dublin, Ireland., Smith CM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Pender EK; Department of Dermatology, St. Vincent's University Hospital, Dublin, Ireland.; Charles Institute of Dermatology, Dublin, Ireland., Mac Mahon J; Department of Dermatology, St. Vincent's University Hospital, Dublin, Ireland.; Charles Institute of Dermatology, Dublin, Ireland., O'Rourke AM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Ismaiel M; Department of Surgery, St. Michael's Hospital, Dublin, Ireland., Boland PA; Department of Surgery, St. Michael's Hospital, Dublin, Ireland., Almeida JP; Department of Surgery, St. Michael's Hospital, Dublin, Ireland., Kennedy C; Department of Surgery, St. Michael's Hospital, Dublin, Ireland., Zaborowski A; Department of Surgery, St. Michael's Hospital, Dublin, Ireland., Murphy S; Department of Plastic Reconstructive and Aesthetic Surgery, Blackrock Clinic, Dublin, Ireland., Winter D; Department of Surgery, St. Michael's Hospital, Dublin, Ireland., Kirby B; Department of Dermatology, St. Vincent's University Hospital, Dublin, Ireland.; Charles Institute of Dermatology, Dublin, Ireland., Fletcher JM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

Publikováno v: The British journal of dermatology [Br J Dermatol] 2023 Nov 16; Vol. 189 (6), pp. 730-740.

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