Serum testosterone, sex hormone-binding globulin and sex-specific risk of incident type 2 diabetes in a retrospective primary care cohort

Autor: O'Reilly, MW, Glisic, Marija, Kumarendran, B, Subramanian, A, Manolopoulos, KN, Tahrani, AA, Keerthy, D, Muka, Taulant, Toulis, KA, Hanif, W, Thomas, GN, Franco Duran, OH, Arlt, W, Nirantharakumar, K

Publikováno v: O'Reilly, Michael W; Glisic, Marija; Kumarendran, Balachandran; Subramanian, Anuradhaa; Manolopoulos, Konstantinos N; Tahrani, Abd A; Keerthy, Deepi; Muka, Taulant; Toulis, Konstantinos A; Hanif, Wasim; Thomas, G Neil; Franco, Oscar H; Arlt, Wiebke; Nirantharakumar, Krishnarajah (2019). Serum testosterone, sex hormone-binding globulin and sex-specific risk of incident type 2 diabetes in a retrospective primary care cohort. Clinical endocrinology, 90(1), pp. 145-154. Blackwell Scientific Publications 10.1111/cen.13862
Clinical Endocrinology, 90(1), 145-154. Wiley-Blackwell Publishing Ltd

OBJECTIVE Previous studies suggest that androgens have a sexually dimorphic impact on metabolic dysfunction. However, the sex-specific link between circulating androgens and risk of type 2 diabetes mellitus (T2DM) has not been examined in a large sca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d8037c56c1fdc5a859e892f2346999

SFRP2 Is Associated with Increased Adiposity and VEGF Expression

Autor: Crowley, RK, O’Reilly, MW, Bujalska, IJ, Hassan-Smith, ZK, Hazlehurst, JM, Foucault, DR, Stewart, PM, Tomlinson, JW

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 9, p e0163777 (2016)

Aims The aim of this study was to assess depot-specific expression and secretion of secreted frizzled-related protein 2 (sFRP2) by adipose tissue and its effect on adipocyte biology. We measured serum sFRP2 concentrations in 106 patients in vivo to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cdfc63cb264599f124b673ac8cbf7004
http://europepmc.org/articles/PMC5042473

The impact of maternal obesity on gestational outcomes.

Autor: Dennedy MC, Avalos G, O'Reilly MW, O'Sullivan EP, Dunne FP

Publikováno v: Irish Medical Journal; May2012, Vol. 105 Issue 5, p23-25, 3p

Impaired 11β-hydroxysteroid dehydrogenase type 2 activity in kidney disease disrupts 11-oxygenated androgen biosynthesis.

Autor: Tomkins M; Androgens in Health and Disease Research Group, Academic Division of Endocrinology, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.; Department of Endocrinology, Beaumont Hospital, Dublin, Ireland., McDonnell T; Androgens in Health and Disease Research Group, Academic Division of Endocrinology, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.; Department of Endocrinology, Beaumont Hospital, Dublin, Ireland., Cussen L; Androgens in Health and Disease Research Group, Academic Division of Endocrinology, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.; Department of Endocrinology, Beaumont Hospital, Dublin, Ireland., Sagmeister MS; Steroid Metabolome Analysis Core (SMAC), Institute of Metabolism and Systems Research, University of Birmingham, UK.; Institute of Applied Health Research, University of Birmingham, Birmingham, UK., Oestlund I; Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa., Shaheen F; Steroid Metabolome Analysis Core (SMAC), Institute of Metabolism and Systems Research, University of Birmingham, UK., Harper L; Institute of Applied Health Research, University of Birmingham, Birmingham, UK., Hardy RS; Institute of Clinical Sciences, University of Birmingham, Birmingham, UK., Taylor AE; Steroid Metabolome Analysis Core (SMAC), Institute of Metabolism and Systems Research, University of Birmingham, UK., Gilligan LC; Steroid Metabolome Analysis Core (SMAC), Institute of Metabolism and Systems Research, University of Birmingham, UK., Arlt W; Steroid Metabolome Analysis Core (SMAC), Institute of Metabolism and Systems Research, University of Birmingham, UK.; Medical Research Council Laboratory of Medical Sciences, London, UK.; Institute of Clinical Sciences, Imperial College London, London, UK., McIlroy M; Androgens in Health and Disease Research Group, Academic Division of Endocrinology, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.; Department of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland., de Freitas D; Department of Nephrology, Beaumont Hospital/RCSI, Dublin, Ireland., Conlon P; Department of Nephrology, Beaumont Hospital/RCSI, Dublin, Ireland., Magee C; Department of Nephrology, Beaumont Hospital/RCSI, Dublin, Ireland., Denton M; Department of Nephrology, Beaumont Hospital/RCSI, Dublin, Ireland., O'Seaghdha C; Department of Nephrology, Beaumont Hospital/RCSI, Dublin, Ireland., Snoep JL; Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa.; Molecular Cell Biology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Storbeck KH; Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa.; Medical Research Council Laboratory of Medical Sciences, London, UK., Sherlock M; Androgens in Health and Disease Research Group, Academic Division of Endocrinology, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.; Department of Endocrinology, Beaumont Hospital, Dublin, Ireland., O'Reilly MW; Androgens in Health and Disease Research Group, Academic Division of Endocrinology, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.; Department of Endocrinology, Beaumont Hospital, Dublin, Ireland.

Publikováno v: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Oct 09. Date of Electronic Publication: 2024 Oct 09.

Replacement with sex steroids in hypopituitary men and women: implications for gender differences in morbidities and mortality.

Autor: Donald DM; Department of Endocrinology, Beaumont Hospital, Royal College of Surgeons of Ireland, Dublin 9, Dublin, Ireland.; Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., McDonnell T; Department of Endocrinology, Beaumont Hospital, Royal College of Surgeons of Ireland, Dublin 9, Dublin, Ireland.; Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., O'Reilly MW; Department of Endocrinology, Beaumont Hospital, Royal College of Surgeons of Ireland, Dublin 9, Dublin, Ireland.; Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Sherlock M; Department of Endocrinology, Beaumont Hospital, Royal College of Surgeons of Ireland, Dublin 9, Dublin, Ireland. marksherlock@rcsi.ie.; Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland. marksherlock@rcsi.ie.

Publikováno v: Reviews in endocrine & metabolic disorders [Rev Endocr Metab Disord] 2024 Oct; Vol. 25 (5), pp. 839-854. Date of Electronic Publication: 2024 Oct 07.