Výsledky vyhledávání - "O'Neill Shane"

Akademický článek

Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke

Autor: Dorscheid Delbert R, Greene Catherine M, MacRedmond Ruth E, McElvaney Noel G, O'Neill Shane J

Publikováno v: Respiratory Research, Vol 8, Iss 1, p 84 (2007)

Abstract The toll-like receptors (TLRs) are a key component of host defense in the respiratory epithelium. Cigarette smoking is associated with increased susceptibility to infection, while COPD is characterised by bacterial colonisation and infective

Externí odkaz: https://doaj.org/article/422a3604068d48d8a3b7fe0ea21c18b1

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Akademický článek

Antimicrobial proteins and polypeptides in pulmonary innate defence

Autor: Taggart Clifford C, O'Neill Shane J, Greene Catherine M, Geraghty Patrick, Rogan Mark P, McElvaney Noel G

Publikováno v: Respiratory Research, Vol 7, Iss 1, p 29 (2006)

Abstract Inspired air contains a myriad of potential pathogens, pollutants and inflammatory stimuli. In the normal lung, these pathogens are rarely problematic. This is because the epithelial lining fluid in the lung is rich in many innate immunity p

Externí odkaz: https://doaj.org/article/fe38198224af4055a22d087c57068e03

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Akademický článek

Respiratory epithelial cells require Toll-like receptor 4 for induction of Human β-defensin 2 by Lipopolysaccharide

Autor: McElvaney Noel, Taggart Clifford C, Greene Catherine, MacRedmond Ruth, O'Neill Shane

Publikováno v: Respiratory Research, Vol 6, Iss 1, p 116 (2005)

Abstract Background The respiratory epithelium is a major portal of entry for pathogens and employs innate defense mechanisms to prevent colonization and infection. Induced expression of human β-defensin 2 (HBD2) represents a direct response by the

Externí odkaz: https://doaj.org/article/106e32dc2ae44e2fa57896e8c166ffc9

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