The native ABC-F proteins of Staphylococcus aureus do not contribute to intrinsic resistance against ribosome-targeting antibacterial drugs.

Autor: Galarion LH; Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Trigwell J; Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Mohamad M; Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Nakamoto JA; Department of Experimental Medical Science, Lund University, Lund, Sweden., Clarke JE; Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Atkinson GC; Department of Experimental Medical Science, Lund University, Lund, Sweden., O'Neill AJ; Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.

Publikováno v: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2023 Oct 03; Vol. 78 (10), pp. 2601-2603.

An extensively validated whole-cell biosensor for specific, sensitive and high-throughput detection of antibacterial inhibitors targeting cell-wall biosynthesis.

Autor: Galarion LH; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK., Mitchell JK; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK., Randall CP; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK., O'Neill AJ; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

Publikováno v: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2023 Mar 02; Vol. 78 (3), pp. 646-655.

Comment on: Identification of a novel tedizolid resistance mutation in rpoB of MRSA after in vitro serial passage.

Autor: Galarion LH; Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Clarke JE; Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Schofield H; Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., O'Neill AJ; Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.

Publikováno v: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2022 Dec 23; Vol. 78 (1), pp. 317-318.

Revisiting unexploited antibiotics in search of new antibacterial drug candidates: the case of gamma-actinorhodin

Autor: Nass, NM, Farooque, S, Hind, C, Wand, ME, Randall, CP, Sutton, JM, Seipke, RF, Rayner, C, O'Neill, AJ

Of the thousands of natural product antibiotics discovered to date, only a handful have been developed for the treatment of bacterial infection. The clinically unexploited majority likely include compounds with untapped potential as antibacterial dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::aaa13654eefef2e3ad1065055c215d49

Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens.

Autor: Crowe-McAuliffe C; Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany., Murina V; Department of Molecular Biology, Umeå University, Umeå, Sweden.; Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden., Turnbull KJ; Department of Molecular Biology, Umeå University, Umeå, Sweden.; Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden., Kasari M; University of Tartu, Institute of Technology, Tartu, Estonia., Mohamad M; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Polte C; Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany., Takada H; Department of Molecular Biology, Umeå University, Umeå, Sweden.; Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden., Vaitkevicius K; Department of Molecular Biology, Umeå University, Umeå, Sweden.; Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden., Johansson J; Department of Molecular Biology, Umeå University, Umeå, Sweden.; Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden., Ignatova Z; Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany., Atkinson GC; Department of Molecular Biology, Umeå University, Umeå, Sweden., O'Neill AJ; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Hauryliuk V; Department of Molecular Biology, Umeå University, Umeå, Sweden. vasili.hauryliuk@med.lu.se.; Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden. vasili.hauryliuk@med.lu.se.; University of Tartu, Institute of Technology, Tartu, Estonia. vasili.hauryliuk@med.lu.se.; Department of Experimental Medical Science, Lund University, Lund, Sweden. vasili.hauryliuk@med.lu.se., Wilson DN; Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany. Daniel.Wilson@chemie.uni-hamburg.de.

Publikováno v: Nature communications [Nat Commun] 2021 Jun 11; Vol. 12 (1), pp. 3577. Date of Electronic Publication: 2021 Jun 11.