Zobrazeno 1 - 10
of 22
pro vyhledávání: '"O'Neil Wiggan"'
Publikováno v:
Cells, Vol 10, Iss 10, p 2726 (2021)
Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons express cofilin-1 as the major isoform, but ADF and cofilin-2 are also exp
Externí odkaz:
https://doaj.org/article/5fd5f401e4a24a16a2483cabf110bfca
Publikováno v:
Molecular Biology of the Cell.
During mitosis, kinetochore-microtubule attachments are monitored by a molecular surveillance system known as the spindle assembly checkpoint. The prevailing model posits that dynein evicts checkpoint proteins (e.g., Mad1, Mad2) from stably attached
Publikováno v:
Molecular Biology of the Cell
Nuclear envelope proteins influence cell cytoarchitecure by poorly understood mechanisms. Here we show that small interfering RNA-mediated silencing of lamin A/C (LMNA) promotes contrasting stress fiber assembly and disassembly in individual cells an
Nuclear envelope proteins influence cell cytoarchitecure by poorly understood mechanisms. Here we show that siRNA-mediated silencing of lamin A/C (LMNA) promotes contrasting stress fiber assembly and disassembly in individual cells and within cell po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb052a194463339cc8b9a955c902ebe7
https://doi.org/10.1101/2020.07.10.197731
https://doi.org/10.1101/2020.07.10.197731
Publikováno v:
Scientific Reports
Structural features of the nucleus including shape, size and deformability impact its function affecting normal cellular processes such as cell differentiation and pathological conditions such as tumor cell migration. Despite the fact that abnormal n
Autor:
J. R. Jensen, James R. Bamburg, Alisa E. Shaw, Michael T. Maloney, Ian T. Marsden, Barbara W. Bernstein, Kevin C. Flynn, Claire Goldsbury, Ineka T. Whiteman, O'Neil Wiggan, Laurie S. Minamide, Richard C. Davis, Chi W. Pak
Publikováno v:
Current Alzheimer Research. 7:241-250
Dephosphorylation (activation) of cofilin, an actin binding protein, is stimulated by initiators of neuronal dysfunction and degeneration including oxidative stress, excitotoxic glutamate, ischemia, and soluble forms of beta-amyloid peptide (Abeta).
Publikováno v:
Cellular Signalling. 18:1501-1514
We previously showed that the transcription factor Pax3 regulates mesenchymal-to-epithelial transition (MET) in cultured osteogenic Saos-2 cells. Herein we demonstrate that Pax3 induced MET in these cells requires intact Pax3 DNA binding motifs and i
Autor:
Ora Bernard, Patrick D. Sarmiere, Nathalie Moussi, Boris Sarcevic, James R. Bamburg, Rashmi Sampath, Sankar Maiti, Juliana Soosairajah, O'Neil Wiggan
Publikováno v:
The EMBO Journal. 24:473-486
Slingshot (SSH) phosphatases and LIM kinases (LIMK) regulate actin dynamics via a reversible phosphorylation (inactivation) of serine 3 in actin-depolymerizing factor (ADF) and cofilin. Here we demonstrate that a multi-protein complex consisting of S
Autor:
James R. Bamburg, O'Neil Wiggan
Publikováno v:
Trends in Cell Biology. 12:598-605
ADF/cofilins are key regulators of actin dynamics in normal cells. Recent findings suggest that, under cellular stress, the wild-type proteins might form complexes with actin that can alter cell function. Owing to their rapid formation, these complex
Publikováno v:
Developmental Dynamics. 213:159-169
We have recently demonstrated that the retinoblastoma family of negative cell cycle regulators can form complexes with a class of developmental factors which contain paired-like (PL) homeodomains (Wiggan et al. [1998] Oncogene 16:227-236). Our screen