Výsledky vyhledávání

Akademický článek

Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life.

Autor: Filipski KJ; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Edmonds DJ; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Garnsey MR; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States.; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Smaltz DJ; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States.; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Coffman K; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Futatsugi K; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Lee J; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., O'Neil SV; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Wright A; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Nason D; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Gosset JR; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Orozco CC; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Blackler D; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Fakhoury G; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Gutierrez JA; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Perez S; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Ross T; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Stock I; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Tesz G; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Dullea R; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Oct 02; Vol. 14 (10), pp. 1427-1433. Date of Electronic Publication: 2023 Oct 02 (Print Publication: 2023).

Zobrazit plný text záznamu

Akademický článek

Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.

Autor: McAllister LA; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Butler CR; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Mente S; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., O'Neil SV; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Fonseca KR; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Piro JR; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Cianfrogna JA; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Foley TL; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Gilbert AM; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Harris AR; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Helal CJ; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Johnson DS; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Montgomery JI; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Nason DM; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Noell S; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Pandit J; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Rogers BN; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Samad TA; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Shaffer CL; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., da Silva RG; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Uccello DP; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Webb D; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Brodney MA; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Apr 12; Vol. 61 (7), pp. 3008-3026. Date of Electronic Publication: 2018 Mar 15.

Zobrazit plný text záznamu

Akademický článek

Design and Synthesis of γ- and δ-Lactam M 1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M 1 -Selective PAM with Weak Agonist Activity.

Autor: Davoren JE, Garnsey M, Pettersen B, Brodney MA, Edgerton JR, Fortin JP, Grimwood S, Harris AR, Jenkinson S; Drug Safety Research and Development, Pfizer Worldwide Research and Development , La Jolla, California 92121, United States., Kenakin T; Department of Pharmacology, University of North Carolina School of Medicine , Chapel Hill, North Carolina 27599, United States., Lazzaro JT, Lee CW, Lotarski SM, Nottebaum L; Drug Safety Research and Development, Pfizer Worldwide Research and Development , La Jolla, California 92121, United States., O'Neil SV, Popiolek M, Ramsey S, Steyn SJ, Thorn CA, Zhang L, Webb D

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Aug 10; Vol. 60 (15), pp. 6649-6663. Date of Electronic Publication: 2017 Jul 26.

Zobrazit plný text záznamu

Akademický článek

Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects.

Autor: Davoren JE, Lee CW, Garnsey M, Brodney MA, Cordes J, Dlugolenski K, Edgerton JR, Harris AR, Helal CJ, Jenkinson S; Drug Safety Research and Development, Pfizer Worldwide Research and Development , La Jolla, California 92121, United States., Kauffman GW, Kenakin TP; Department of Pharmacology, University of North Carolina School of Medicine , Chapel Hill, North Carolina 27599, United States., Lazzaro JT, Lotarski SM, Mao Y, Nason DM, Northcott C, Nottebaum L; Drug Safety Research and Development, Pfizer Worldwide Research and Development , La Jolla, California 92121, United States., O'Neil SV, Pettersen B, Popiolek M, Reinhart V, Salomon-Ferrer R, Steyn SJ, Webb D, Zhang L, Grimwood S

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 Jul 14; Vol. 59 (13), pp. 6313-28. Date of Electronic Publication: 2016 Jul 01.

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání