Zobrazeno 1 - 10
of 39
pro vyhledávání: '"O'Neal Copeland"'
Autor:
O’neal Copeland, Andrew Messer, Andrew Jabbour, Corrado Poggesi, Sanjay Prasad, Steven Marston
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
In previous studies of septal heart muscle from HCM patients with hypertrophic obstructive cardiomyopathy (HOCM, LVOT gradient 50–120 mmHg) we found that the level of phosphorylation of troponin I (TnI) and myosin binding protein C (MyBP-C) was ext
Externí odkaz:
https://doaj.org/article/07f6047762bf4133aae2b9b6a732267e
Autor:
Andrew E. Messer, Jasmine Chan, Alex Daley, O'Neal Copeland, Steven B. Marston, David J. Connolly
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Hypertrophic cardiomyopathy (HCM) is the most common single gene inherited cardiomyopathy. In cats (Felix catus) HCM is even more prevalent and affects 16% of the outbred population and up to 26% in pedigree breeds such as Maine Coon and Ragdoll. Hom
Externí odkaz:
https://doaj.org/article/a15b31b712f7450db776b864cdd7c907
Autor:
Steven Marston, Cecile Montgiraud, Alex B Munster, O'Neal Copeland, Onjee Choi, Cristobal Dos Remedios, Andrew E Messer, Elisabeth Ehler, Ralph Knöll
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138568 (2015)
BackgroundStudies of the functional consequences of DCM-causing mutations have been limited to a few cases where patients with known mutations had heart transplants. To increase the number of potential tissue samples for direct investigation we perfo
Externí odkaz:
https://doaj.org/article/21b7a55348dd474487eea475a9a01194
Autor:
Andrew E. Messer, Corrado Poggesi, Andrew Jabbour, Sanjay K Prasad, O'Neal Copeland, Steven B. Marston
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Frontiers in Physiology
Frontiers in Physiology
In previous studies of septal heart muscle from HCM patients with hypertrophic obstructive cardiomyopathy (HOCM, LVOT gradient 50–120 mmHg) we found that the level of phosphorylation of troponin I (TnI) and myosin binding protein C (MyBP-C) was ext
Autor:
Petr G. Vikhorev, Natalia Smoktunowicz, Alex B. Munster, O’Neal Copeland, Sawa Kostin, Cecile Montgiraud, Andrew E. Messer, Mohammad R. Toliat, Amy Li, Cristobal G. dos Remedios, Sean Lal, Cheavar A. Blair, Kenneth S. Campbell, Maya Guglin, Manfred Richter, Ralph Knöll, Steven B. Marston
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Dilated cardiomyopathy (DCM) is an important cause of heart failure. Single gene mutations in at least 50 genes have been proposed to account for 25–50% of DCM cases and up to 25% of inherited DCM has been attributed to truncating mutations in the
Autor:
Mohammed El-Mezgueldi, M Mirza, Nikolaeva Op, Dimitry Levitsky, Paul Robinson, Elena Kremneva, Hugh Watkins, O'Neal Copeland, Charles Redwood, Steven B. Marston
E40K and E54K mutations in alpha-tropomyosin cause inherited dilated cardiomyopathy. Previously we showed, using Ala-Ser alpha-tropomyosin (AS-alpha-Tm) expressed in Escherichia coli, that both mutations decrease Ca(2+) sensitivity. E40K also reduces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eff9b5d068ab0ef03fc20d526f9ba8b
https://doi.org/10.1074/jbc.m701071200
https://doi.org/10.1074/jbc.m701071200
Autor:
Andrew E. Messer, Adam Jacques, Clare E. Gallon, Cristobal G. dos Remedios, Steven B. Marston, Christopher R. Bayliss, Charles Redwood, O'Neal Copeland, Man-Ching Leung, William J. McKenna, Douglas G. Ward
Publikováno v:
Cardiovascular Research
Cardiovascular Research; Vol 97
Cardiovascular Research; Vol 97
AIMS: We studied the relationship between myofilament Ca(2+) sensitivity and troponin I (TnI) phosphorylation by protein kinase A at serines 22/23 in human heart troponin isolated from donor hearts and from myectomy samples from patients with hypertr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cdae478b45f75452d02d0879c3c3fec
https://ora.ox.ac.uk/objects/uuid:6a4c5515-82ba-4813-98d8-1c82b19966d8
https://ora.ox.ac.uk/objects/uuid:6a4c5515-82ba-4813-98d8-1c82b19966d8
Autor:
Markus B. Sikkel, Iratxe Torre, Valentina Caorsi, Steven B. Marston, Pradeep K. Luther, Kenneth T. MacLeod, Timothy G. West, Alexander R. Lyon, Christopher N. Toepfer, Anupama Vydyanath, Michael A. Ferenczi, O'Neal Copeland
Publikováno v:
H475
H465
American Journal of Physiology-Heart and Circulatory Physiology
H465
American Journal of Physiology-Heart and Circulatory Physiology
Compensation postchronic myocardial infarction (CMI) in rats is characterized in trabeculae as increased force and power production during physiological shortening, which occurs alongside classical hypertrophy. Sarcomeric contractile gain is influenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366cc0f5660a20778dd9e2534bae35ae
http://hdl.handle.net/10044/1/34272
http://hdl.handle.net/10044/1/34272
Autor:
Jordi L. Tremoleda, Lorenzo Monserrat, Charles Redwood, Daniel J. Stuckey, Steven B. Marston, Kieran Clarke, Weihua Song, Michael D. Schneider, Kristen J. Nowak, Man-Ching Leung, Christopher Bayliss, Sian E. Harding, Andrew E. Messer, Emma Dyer, O'Neal Copeland, Ross Wilkinson, Dominic J. Wells
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry; Vol 286
Journal of Biological Chemistry; Vol 286
We generated a transgenic mouse model expressing the apical hypertrophic cardiomyopathy-causing mutation ACTC E99K at 50% of total heart actin and compared it with actin from patients carrying the same mutation. The actin mutation caused a higher Ca(
Autor:
Steven B. Marston, Ger J.M. Steinen, Jolanda van der Velden, Sakthivel Sadayappan, Andrew E. Messer, O'Neal Copeland
Publikováno v:
Journal of Molecular and Cellular Cardiology, 49(6), 1003-1011. Academic Press Inc.
Copeland, O, Sadayappan, S, Messer, A E, Stienen, G J M, van der Velden, J & Marston, S B 2010, ' Analysis of cardiac myosin binding protein-C phosphorylation in human heart muscle ', Journal of Molecular and Cellular Cardiology, vol. 49, no. 6, pp. 1003-1011 . https://doi.org/10.1016/j.yjmcc.2010.09.007
Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology; Vol 49
Copeland, O, Sadayappan, S, Messer, A E, Stienen, G J M, van der Velden, J & Marston, S B 2010, ' Analysis of cardiac myosin binding protein-C phosphorylation in human heart muscle ', Journal of Molecular and Cellular Cardiology, vol. 49, no. 6, pp. 1003-1011 . https://doi.org/10.1016/j.yjmcc.2010.09.007
Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology; Vol 49
A unique feature of MyBP-C in cardiac muscle is that it has multiple phosphorylation sites. MyBP-C phosphorylation, predominantly by PKA, plays an essential role in modulating contractility as part of the cellular response to β-adrenergic stimulatio