mRNA- and factor-driven dynamic variability controls eIF4F-cap recognition for translation initiation

Autor: O’Leary Se, Burak Çetin

SUMMARYmRNA 5ʹ cap recognition by eIF4F is a key step in eukaryotic translational control. While different mRNAs respond differently to eIF4F-directed regulation, the molecular basis for this variability remains unclear. We developed single-molecule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c1e0358122b80c5b1e6bc1255325251
https://doi.org/10.1101/2021.06.17.448745

Single-molecule tracking reveals dynamic regulation of ribosomal scanning.

Autor: Hong HJ; Department of Biochemistry, University of California Riverside, Riverside, CA 92521, USA., Zhang AL; Department of Biochemistry, University of California Riverside, Riverside, CA 92521, USA., Conn AB; Department of Biochemistry, University of California Riverside, Riverside, CA 92521, USA., Blaha G; Department of Biochemistry, University of California Riverside, Riverside, CA 92521, USA.; Center for RNA Biology and Medicine, University of California Riverside, Riverside, CA 92521, USA., O'Leary SE; Department of Biochemistry, University of California Riverside, Riverside, CA 92521, USA.; Center for RNA Biology and Medicine, University of California Riverside, Riverside, CA 92521, USA.

Publikováno v: Science advances [Sci Adv] 2024 Oct 04; Vol. 10 (40), pp. eadm9801. Date of Electronic Publication: 2024 Oct 02.

Translation initiation factor eIF1.2 promotes Toxoplasma stage conversion by regulating levels of key differentiation factors.

Autor: Wang F; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Holmes MJ; Department of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Hong HJ; Department of Biochemistry, University of California Riverside, Riverside, CA, 92521, USA., Thaprawat P; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.; Medical Scientist Training Program, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Kannan G; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Huynh MH; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Schultz TL; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Licon MH; Whitehead Institute, Cambridge, MA, 02142, USA., Lourido S; Whitehead Institute, Cambridge, MA, 02142, USA.; Biology Department, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA., Dong W; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.; Life Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, USA.; Center for RNA Biomedicine, University of Michigan, Ann Arbor, MI, 48109, USA., Brito Querido J; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.; Life Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, USA.; Center for RNA Biomedicine, University of Michigan, Ann Arbor, MI, 48109, USA., Sullivan WJ Jr; Department of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Department of Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., O'Leary SE; Department of Biochemistry, University of California Riverside, Riverside, CA, 92521, USA.; Center for RNA Biology and Medicine, University of California Riverside, Riverside, CA, 92521, USA., Carruthers VB; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. vcarruth@umich.edu.

Publikováno v: Nature communications [Nat Commun] 2024 May 23; Vol. 15 (1), pp. 4385. Date of Electronic Publication: 2024 May 23.

DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation.

Autor: Ren W; Department of Biochemistry, University of California, Riverside, CA, USA., Fan H; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Grimm SA; Division of Intramural Research, Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, USA., Kim JJ; Department of Molecular Biosciences, LIVESTRONG Cancer Institute of the Dell Medical School, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA., Li L; Department of Biochemistry, University of California, Riverside, CA, USA., Guo Y; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Petell CJ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Tan XF; Department of Biochemistry, University of California, Riverside, CA, USA., Zhang ZM; Department of Biochemistry, University of California, Riverside, CA, USA., Coan JP; Department of Biology, Stanford University, Stanford, CA, USA., Yin J; Environmental Toxicology Graduate Program, University of California, Riverside, CA, USA., Kim DI; Department of Molecular Biosciences, LIVESTRONG Cancer Institute of the Dell Medical School, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA., Gao L; Environmental Toxicology Graduate Program, University of California, Riverside, CA, USA., Cai L; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Khudaverdyan N; Department of Biochemistry, University of California, Riverside, CA, USA., Çetin B; Cell, Molecular, and Developmental Biology Graduate Program, University of California, Riverside, Riverside, CA, USA., Patel DJ; Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Wang Y; Environmental Toxicology Graduate Program, University of California, Riverside, CA, USA.; Department of Chemistry, University of California, Riverside, CA, USA., Cui Q; Departments of Chemistry, Physics and Biomedical Engineering, Boston University, Boston, MA, USA., Strahl BD; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Gozani O; Department of Biology, Stanford University, Stanford, CA, USA., Miller KM; Department of Molecular Biosciences, LIVESTRONG Cancer Institute of the Dell Medical School, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA., O'Leary SE; Department of Biochemistry, University of California, Riverside, CA, USA.; Cell, Molecular, and Developmental Biology Graduate Program, University of California, Riverside, Riverside, CA, USA., Wade PA; Division of Intramural Research, Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, USA., Wang GG; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. greg_wang@med.unc.edu.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. greg_wang@med.unc.edu., Song J; Department of Biochemistry, University of California, Riverside, CA, USA. jikui.song@ucr.edu.; Environmental Toxicology Graduate Program, University of California, Riverside, CA, USA. jikui.song@ucr.edu.

Publikováno v: Nature communications [Nat Commun] 2021 May 03; Vol. 12 (1), pp. 2490. Date of Electronic Publication: 2021 May 03.

Structural basis for STAT2 suppression by flavivirus NS5.

Autor: Wang B; Department of Biochemistry, University of California, Riverside, CA, USA., Thurmond S; Department of Microbiology and Plant Pathology, University of California, Riverside, CA, USA.; Cell, Molecular and Developmental Biology Graduate Program, University of California, Riverside, CA, USA., Zhou K; California NanoSystems Institute, University of California, Los Angeles, CA, USA., Sánchez-Aparicio MT; GlobalHealth and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Fang J; Department of Biochemistry, University of California, Riverside, CA, USA., Lu J; Department of Biochemistry, University of California, Riverside, CA, USA., Gao L; Environmental Toxicology Graduate Program, University of California, Riverside, CA, USA., Ren W; Department of Biochemistry, University of California, Riverside, CA, USA., Cui Y; California NanoSystems Institute, University of California, Los Angeles, CA, USA., Veit EC; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hong H; Department of Biochemistry, University of California, Riverside, CA, USA., Evans MJ; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., O'Leary SE; Department of Biochemistry, University of California, Riverside, CA, USA., García-Sastre A; GlobalHealth and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zhou ZH; California NanoSystems Institute, University of California, Los Angeles, CA, USA. Hong.Zhou@ucla.edu.; Departement of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, USA. Hong.Zhou@ucla.edu., Hai R; Department of Microbiology and Plant Pathology, University of California, Riverside, CA, USA. ronghai@ucr.edu.; Cell, Molecular and Developmental Biology Graduate Program, University of California, Riverside, CA, USA. ronghai@ucr.edu., Song J; Department of Biochemistry, University of California, Riverside, CA, USA. jikui.song@ucr.edu.; Environmental Toxicology Graduate Program, University of California, Riverside, CA, USA. jikui.song@ucr.edu.

Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Oct; Vol. 27 (10), pp. 875-885. Date of Electronic Publication: 2020 Aug 10.