An mRNA-encoded dominant-negative inhibitor of transcription factor RUNX1 suppresses vitreoretinal disease in experimental models.

Autor: O'Hare M; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Miller WP; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Arevalo-Alquichire S; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Amarnani D; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Apryani E; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Perez-Corredor P; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Marino C; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Shu DY; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Vanderleest TE; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Muriel-Torres A; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Gordon HB; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Gunawan AL; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Kaplan BA; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Barake KW; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Bejjani RP; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Doan TH; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Lin R; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Delgado-Tirado S; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Gonzalez-Buendia L; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Rossin EJ; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Zhao G; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Eliott D; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Weinl-Tenbruck C; CureVac SE, Tübingen, 72076, Germany., Chevessier-Tünnesen F; CureVac SE, Tübingen, 72076, Germany., Rejman J; CureVac SE, Tübingen, 72076, Germany., Montrasio F; CureVac SE, Tübingen, 72076, Germany., Kim LA; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA., Arboleda-Velasquez JF; Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.; Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, MA 02114, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Nov 27; Vol. 16 (775), pp. eadh0994. Date of Electronic Publication: 2024 Nov 27.

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APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation.

Autor: Marino C; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Perez-Corredor P; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., O'Hare M; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Heuer A; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Chmielewska N; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Gordon H; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Chandrahas AS; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Gonzalez-Buendia L; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Delgado-Tirado S; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Doan TH; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Vanderleest TE; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Arevalo-Alquichire S; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Obar RA; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA., Ortiz-Cordero C; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Villegas A; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia., Sepulveda-Falla D; Molecular Neuropathology of Alzheimer's Disease, Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kim LA; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Lopera F; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia., Mahley R; Gladstone Institute of Neurological Disease, San Francisco, California, USA.; Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA.; Department of Pathology, UCSF, San Francisco, California, USA.; Department of Medicine, UCSF, San Francisco, California, USA.; Cardiovascular Research Institute, UCSF, San Francisco, California, USA., Huang Y; Gladstone Institute of Neurological Disease, San Francisco, California, USA.; Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA.; Department of Pathology, UCSF, San Francisco, California, USA.; Department of Neurology, UCSF, San Francisco, California, USA., Quiroz YT; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Arboleda-Velasquez JF; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Feb; Vol. 20 (2), pp. 819-836. Date of Electronic Publication: 2023 Oct 04.

Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous man.

Autor: Lopera F; Neuroscience Group of Antioquia, Medicine School, University of Antioquia, Medellín, Colombia.; Medicine School, University of Antioquia, Medellín, Colombia., Marino C; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, MA, USA., Chandrahas AS; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, MA, USA., O'Hare M; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, MA, USA., Villalba-Moreno ND; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Aguillon D; Neuroscience Group of Antioquia, Medicine School, University of Antioquia, Medellín, Colombia.; Medicine School, University of Antioquia, Medellín, Colombia., Baena A; Neuroscience Group of Antioquia, Medicine School, University of Antioquia, Medellín, Colombia., Sanchez JS; Department of Neurology at Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Vila-Castelar C; Department of Psychiatry at Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Ramirez Gomez L; Department of Neurology at Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Chmielewska N; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, MA, USA., Oliveira GM; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, MA, USA.; Department of Psychiatry at Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Littau JL; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hartmann K; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Park K; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Krasemann S; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Glatzel M; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schoemaker D; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, MA, USA.; Department of Psychiatry at Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Gonzalez-Buendia L; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, MA, USA., Delgado-Tirado S; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, MA, USA., Arevalo-Alquichire S; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, MA, USA., Saez-Torres KL; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, MA, USA., Amarnani D; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, MA, USA., Kim LA; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, MA, USA., Mazzarino RC; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, MA, USA., Gordon H; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, MA, USA., Bocanegra Y; Neuroscience Group of Antioquia, Medicine School, University of Antioquia, Medellín, Colombia., Villegas A; Neuroscience Group of Antioquia, Medicine School, University of Antioquia, Medellín, Colombia.; Medicine School, University of Antioquia, Medellín, Colombia., Gai X; Center for Personalized Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.; Department of Pathology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA., Bootwalla M; Center for Personalized Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA., Ji J; Center for Personalized Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.; Department of Pathology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA., Shen L; Center for Personalized Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA., Kosik KS; Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, CA, USA., Su Y; The Banner Alzheimer's Institute, Phoenix, AZ, USA., Chen Y; The Banner Alzheimer's Institute, Phoenix, AZ, USA., Schultz A; Department of Neurology at Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Sperling RA; Department of Neurology at Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Johnson K; Department of Neurology at Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.; Department of Radiology at Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Reiman EM; The Banner Alzheimer's Institute, Phoenix, AZ, USA.; University of Arizona, Tucson, AZ, USA.; Arizona State University, Tucson, AZ, USA.; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA., Sepulveda-Falla D; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. d.sepulveda-falla@uke.uni-hamburg.de., Arboleda-Velasquez JF; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, MA, USA. joseph_arboleda@meei.harvard.edu., Quiroz YT; Neuroscience Group of Antioquia, Medicine School, University of Antioquia, Medellín, Colombia. yquiroz@mgh.harvard.edu.; Department of Neurology at Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA. yquiroz@mgh.harvard.edu.; Department of Psychiatry at Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA. yquiroz@mgh.harvard.edu.

Publikováno v: Nature medicine [Nat Med] 2023 May; Vol. 29 (5), pp. 1243-1252. Date of Electronic Publication: 2023 May 15.

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