Multivalent mRNA-DTP vaccines are immunogenic and provide protection from Bordetella pertussis challenge in mice.

Autor: Wolf MA; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., O'Hara JM; Moderna Inc., Cambridge, MA, 02139, USA., Bitzer GJ; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., Narayanan E; Moderna Inc., Cambridge, MA, 02139, USA., Boehm DT; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., Bevere JR; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., DeJong MA; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., Hall JM; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., Wong TY; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., Falcone S; Moderna Inc., Cambridge, MA, 02139, USA., Deal CE; Moderna Inc., Cambridge, MA, 02139, USA., Richards A; Moderna Inc., Cambridge, MA, 02139, USA., Green S; Moderna Inc., Cambridge, MA, 02139, USA., Nguyen B; Moderna Inc., Cambridge, MA, 02139, USA., King E; Moderna Inc., Cambridge, MA, 02139, USA., Ogega C; Moderna Inc., Cambridge, MA, 02139, USA., Russo L; Moderna Inc., Cambridge, MA, 02139, USA., Sen-Kilic E; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., Plante O; Moderna Inc., Cambridge, MA, 02139, USA., Himansu S; Moderna Inc., Cambridge, MA, 02139, USA., Barbier M; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., Carfi A; Moderna Inc., Cambridge, MA, 02139, USA., Damron FH; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA. fdamron@hsc.wvu.edu.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA. fdamron@hsc.wvu.edu.

Publikováno v: NPJ vaccines [NPJ Vaccines] 2024 Jun 10; Vol. 9 (1), pp. 103. Date of Electronic Publication: 2024 Jun 10.

Generation of protective pneumococcal-specific nasal resident memory CD4 ⁺ T cells via parenteral immunization.

Autor: O'Hara JM; Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Redhu NS; Harvard Medical School, Boston, MA, USA.; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA., Cheung E; Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Robertson NG; Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA., Patik I; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Sayed SE; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Thompson CM; Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA., Herd M; Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA., Lucas KB; Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA., Conaway E; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA., Morton CC; Harvard Medical School, Boston, MA, USA.; Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Farber DL; Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USA., Malley R; Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA. richard.malley@childrens.harvard.edu.; Harvard Medical School, Boston, MA, USA. richard.malley@childrens.harvard.edu., Horwitz BH; Harvard Medical School, Boston, MA, USA. bhorwitz@rics.bwh.harvard.edu.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA. bhorwitz@rics.bwh.harvard.edu.; Division of Emergency Medicine, Boston Children's Hospital, Boston, MA, USA. bhorwitz@rics.bwh.harvard.edu.

Publikováno v: Mucosal immunology [Mucosal Immunol] 2020 Jan; Vol. 13 (1), pp. 172-182. Date of Electronic Publication: 2019 Oct 28.

Neutralizing Monoclonal Antibodies against Disparate Epitopes on Ricin Toxin's Enzymatic Subunit Interfere with Intracellular Toxin Transport.

Autor: Yermakova A; Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY 12208.; Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, NY 12201., Klokk TI; Department of Molecular Cell Biology, Centre for Cancer Biomedicine, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway., O'Hara JM; Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY 12208.; Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, NY 12201., Cole R; Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, NY 12201.; Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201., Sandvig K; Department of Molecular Cell Biology, Centre for Cancer Biomedicine, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway.; Department of Biosciences, University of Oslo, Oslo, Norway., Mantis NJ; Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY 12208.; Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, NY 12201.

Publikováno v: Scientific reports [Sci Rep] 2016 Mar 07; Vol. 6, pp. 22721. Date of Electronic Publication: 2016 Mar 07.

Stabilization of a recombinant ricin toxin A subunit vaccine through lyophilization.

Autor: Hassett KJ; Department of Chemical and Biological Engineering, University of Colorado, Boulder, USA., Cousins MC, Rabia LA, Chadwick CM, O'Hara JM, Nandi P, Brey RN, Mantis NJ, Carpenter JF, Randolph TW

Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2013 Oct; Vol. 85 (2), pp. 279-86. Date of Electronic Publication: 2013 Apr 10.

LT-IIb(T13I), a non-toxic type II heat-labile enterotoxin, augments the capacity of a ricin toxin subunit vaccine to evoke neutralizing antibodies and protective immunity.

Autor: Greene CJ; The Witebsky Center for Microbial Pathogenesis and Immunology, The University at Buffalo, Buffalo, New York, United States of America., Chadwick CM, Mandell LM, Hu JC, O'Hara JM, Brey RN 3rd, Mantis NJ, Connell TD

Publikováno v: PloS one [PLoS One] 2013 Aug 02; Vol. 8 (8), pp. e69678. Date of Electronic Publication: 2013 Aug 02 (Print Publication: 2013).