Pancreatic Cancer Risk in Relation to Lifetime Smoking Patterns, Tobacco Type, and Dose-Response Relationships

Autor: Molina-Montes, Esther, Van Hoogstraten, Lisa, Gomez-Rubio, Paulina, Lohr, Matthias, Sharp, Linda, Molero, Xavier, Marquez, Mirari, Michalski, Christoph W, Farre, Antoni, Perea, Jose, O'Rorke, Michael, Greenhalf, William, Ilzarbe, Lucas, Tardon, Adonina, Gress, Thomas M, Barbera, Victor M, Crnogorac-Jurcevic, Tatjana, Munoz-Bellvis, Luis, Dominguez-Munoz, Enrique, Balsells, Joaquim, Costello, Eithne, Iglesias, Mar, Kleeff, Jorg, Kong, Bo, Mora, Josefina, O'Driscoll, Damian, Poves, Ignasi, Scarpa, Aldo, Yu, Jingru, Ye, Weimin, Hidalgo, Manuel, Carrato, Alfredo, Lawlor, Rita, Real, Francisco X, Malats, Nuria, Investigators, PanGenEu Study

Publikováno v: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
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Background: Despite smoking being a well-established risk factor for pancreatic cancer, there is a need to further characterize pancreatic cancer risk according to lifespan smoking patterns and other smoking features, such as tobacco type. Our aim wa

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A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

Autor: López De Maturana, Evangelina, Rodríguez, Juan Antonio, Alonso, Lola, Lao, Oscar, Molina-Montes, Esther, Martín-Antoniano, Isabel Adoración, Gómez-Rubio, Paulina, Lawlor, Rita, Carrato, Alfredo, Hidalgo, Manuel, Iglesias, Mar, Molero, Xavier, Löhr, Matthias, Michalski, Christopher, Perea, José, O'Rorke, Michael, Barberà, Victor Manuel, Tardón, Adonina, Farré, Antoni, Muñoz-Bellvís, Luís, Crnogorac-Jurcevic, Tanja, Domínguez-Muñoz, Enrique, Gress, Thomas, Greenhalf, William, Sharp, Linda, Arnes, Luís, Cecchini, Lluís, Balsells, Joaquim, Costello, Eithne, Ilzarbe, Lucas, Kleeff, Jörg, Kong, Bo, Márquez, Mirari, Mora, Josefina, O'Driscoll, Damian, Scarpa, Aldo, Ye, Weimin, Yu, Jingru, PanGenEU Investigators, García-Closas, Montserrat, Kogevinas, Manolis, Rothman, Nathaniel, Silverman, Debra T, SBC/EPICURO Investigators, Albanes, Demetrius, Arslan, Alan A, Beane-Freeman, Laura, Bracci, Paige M, Brennan, Paul, Bueno-De-Mesquita, Bas, Buring, Julie, Canzian, Federico, Du, Margaret, Gallinger, Steve, Gaziano, J Michael, Goodman, Phyllis J, Gunter, Marc, LeMarchand, Loic, Li, Donghui, Neale, Rachael E, Peters, Ulrika, Petersen, Gloria M, Risch, Harvey A, Sánchez, Maria José, Shu, Xiao-Ou, Thornquist, Mark D, Visvanathan, Kala, Zheng, Wei, Chanock, Stephen J, Easton, Douglas, Wolpin, Brian M, Stolzenberg-Solomon, Rachael Z, Klein, Alison P, Amundadottir, Laufey T, Marti-Renom, Marc A, Real, Francisco X, Malats, Núria

BACKGROUND: Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% of the phenotypic variance. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2ca7501ee0d0caea0fc4a452e0c4f0e

Pancreatic Cancer Risk in Relation to Lifetime Smoking Patterns, Tobacco Type, and Dose-Response Relationships.

Autor: Molina-Montes E; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, and CIBERONC, Spain. nmalats@cnio.es memolina@cnio.es., Van Hoogstraten L; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, and CIBERONC, Spain., Gomez-Rubio P; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, and CIBERONC, Spain., Löhr M; Gastrocentrum, Karolinska Institutet and University Hospital, Stockholm, Sweden., Sharp L; National Cancer Registry Ireland and HRB Clinical Research Facility, University College Cork, Cork, Ireland.; Newcastle University, Institute of Health & Society, Newcastle, United Kingdom., Molero X; Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Barcelona, Universitat Autònoma de Barcelona, CIBEREHD, Spain., Márquez M; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, and CIBERONC, Spain., Michalski CW; Department of Surgery, Technical University of Munich, Munich, Germany.; Department of Visceral, Vascular and Endocrine Surgery, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany., Farré A; Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Perea J; Department of Surgery, Hospital 12 de Octubre, Madrid, Spain.; Department of Surgery and Health Research Institute, Fundación Jiménez Díaz, Madrid, Spain., O'Rorke M; Centre for Public Health, Belfast, Queen's University Belfast, United Kingdom.; College of Public Health, The University of Iowa, Iowa City, Iowa., Greenhalf W; Department of Molecular and Clinical Cancer Medicine, The Royal Liverpool University Hospital, Liverpool, United Kingdom., Ilzarbe L; Hospital del Mar-Parc de Salut Mar, Barcelona, CIBERONC, Spain., Tardon A; Department of Medicine, Instituto Universitario de Oncología del Principado de Asturias, Oviedo, CIBERESP, Spain., Gress TM; Department of Gastroenterology, University Hospital of Giessen and Marburg, Marburg, Germany., Barberà VM; Molecular Genetics Laboratory, General University Hospital of Elche, Spain., Crnogorac-Jurcevic T; Barts Cancer Institute, Centre for Molecular Oncology, Queen Mary University of London, London, United Kingdom., Muñoz-Bellvis L; General and Digestive Surgery Department, Salamanca University Hospital, Spain., Domínguez-Muñoz E; Department of Gastroenterology, University Clinical Hospital of Santiago de Compostela, Spain., Balsells J; Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Barcelona, Universitat Autònoma de Barcelona, CIBEREHD, Spain., Costello E; Department of Molecular and Clinical Cancer Medicine, The Royal Liverpool University Hospital, Liverpool, United Kingdom., Iglesias M; Hospital del Mar-Parc de Salut Mar, Barcelona, CIBERONC, Spain., Kleeff J; Department of Surgery, Technical University of Munich, Munich, Germany.; Department of Visceral, Vascular and Endocrine Surgery, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany., Kong B; Department of Surgery, Technical University of Munich, Munich, Germany., Mora J; Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., O'Driscoll D; National Cancer Registry Ireland and HRB Clinical Research Facility, University College Cork, Cork, Ireland., Poves I; Hospital del Mar-Parc de Salut Mar, Barcelona, CIBERONC, Spain., Scarpa A; ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy., Yu J; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stokholm, Sweden., Ye W; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stokholm, Sweden., Hidalgo M; Madrid-Norte-Sanchinarro Hospital, Madrid, Spain.; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts., Carrato A; Department of Oncology, Ramón y Cajal University Hospital, IRYCIS, Alcala University, Madrid and CIBERONC, Spain., Lawlor R; ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy., Real FX; Epithelial Carcinogenesis Group, Madrid, Spanish National Cancer Research Centre (CNIO), Madrid, Universitat Pompeu Fabra, Departament de Ciències Experimentals i de la Salut, Barcelona, and CIBERONC, Spain., Malats N

Publikováno v: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2020 May; Vol. 29 (5), pp. 1009-1018. Date of Electronic Publication: 2020 Feb 12.