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Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.

Autor: Yavari A; Experimental Therapeutics, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. Electronic address: arash.yavari@well.ox.ac.uk., Stocker CJ; The Buckingham Institute for Translational Medicine, University of Buckingham, Buckingham MK18 1EG, UK., Ghaffari S; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Wargent ET; The Buckingham Institute for Translational Medicine, University of Buckingham, Buckingham MK18 1EG, UK., Steeples V; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Czibik G; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Pinter K; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Bellahcene M; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Woods A; Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College London, London SW7 2AZ, UK., Martínez de Morentin PB; Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB25 2ZD, UK., Cansell C; Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB25 2ZD, UK., Lam BY; University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Chuster A; Pos Graduação Ciências Médicas, Faculdade Ciências Médicas, Universidade Federal de Minas Gerais, Belo Horizonte-MG 31270-901, Brazil., Petkevicius K; University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Nguyen-Tu MS; Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology, and Metabolism, Imperial College London, London SW7 2AZ, UK., Martinez-Sanchez A; Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology, and Metabolism, Imperial College London, London SW7 2AZ, UK., Pullen TJ; Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology, and Metabolism, Imperial College London, London SW7 2AZ, UK., Oliver PL; MRC Functional Genomics Unit, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, UK., Stockenhuber A; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Nguyen C; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Lazdam M; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK., O'Dowd JF; The Buckingham Institute for Translational Medicine, University of Buckingham, Buckingham MK18 1EG, UK., Harikumar P; The Buckingham Institute for Translational Medicine, University of Buckingham, Buckingham MK18 1EG, UK., Tóth M; Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest 1083, Hungary., Beall C; Cardiovascular and Diabetes Medicine, Medical Research Institute, University of Dundee, Dundee DD1 9SY, UK., Kyriakou T; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Parnis J; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Sarma D; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Katritsis G; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Wortmann DD; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Harper AR; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Brown LA; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK., Willows R; Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College London, London SW7 2AZ, UK., Gandra S; Pos Graduação Ciências Médicas, Faculdade Ciências Médicas, Universidade Federal de Minas Gerais, Belo Horizonte-MG 31270-901, Brazil., Poncio V; Universidade Estadual de Campinas, Campinas-SP 13083-970, Brazil., de Oliveira Figueiredo MJ; Universidade Estadual de Campinas, Campinas-SP 13083-970, Brazil., Qi NR; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Peirson SN; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK., McCrimmon RJ; Cardiovascular and Diabetes Medicine, Medical Research Institute, University of Dundee, Dundee DD1 9SY, UK., Gereben B; Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest 1083, Hungary., Tretter L; Department of Medical Biochemistry, Semmelweis University, Budapest 1085, Hungary; MTA-SE Laboratory for Neurobiochemistry, Semmelweis University, Budapest 1085, Hungary., Fekete C; Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest 1083, Hungary; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Tupper Research Institute, Tufts Medical Center, Boston, MA 02111, USA., Redwood C; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Yeo GS; University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Heisler LK; Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB25 2ZD, UK., Rutter GA; Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology, and Metabolism, Imperial College London, London SW7 2AZ, UK., Smith MA; Metabolic Signalling Group, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, UK., Withers DJ; Metabolic Signalling Group, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, UK., Carling D; Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College London, London SW7 2AZ, UK., Sternick EB; Pos Graduação Ciências Médicas, Faculdade Ciências Médicas, Universidade Federal de Minas Gerais, Belo Horizonte-MG 31270-901, Brazil., Arch JR; The Buckingham Institute for Translational Medicine, University of Buckingham, Buckingham MK18 1EG, UK., Cawthorne MA; The Buckingham Institute for Translational Medicine, University of Buckingham, Buckingham MK18 1EG, UK., Watkins H; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Ashrafian H; Experimental Therapeutics, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Experimental Therapeutics, Clinical Science Group, New Medicines, UCB Pharma S.A., Slough, Berkshire SL1 3WE, UK. Electronic address: houman.ashrafian@cardiov.ox.ac.uk.

Publikováno v: Cell metabolism [Cell Metab] 2016 May 10; Vol. 23 (5), pp. 821-36. Date of Electronic Publication: 2016 Apr 28.

Circulating levels of the cytokines IL10, IFNγ and resistin in an obese mouse model of developmental programming.

Autor: Kępczyńska MA; Clore Laboratory, University of Buckingham, Buckingham, UK., Wargent ET; Clore Laboratory, University of Buckingham, Buckingham, UK., Cawthorne MA; Clore Laboratory, University of Buckingham, Buckingham, UK., Arch JR; Clore Laboratory, University of Buckingham, Buckingham, UK., O'Dowd JF; Clore Laboratory, University of Buckingham, Buckingham, UK., Stocker CJ; Clore Laboratory, University of Buckingham, Buckingham, UK.

Publikováno v: Journal of developmental origins of health and disease [J Dev Orig Health Dis] 2013 Dec; Vol. 4 (6), pp. 491-8.

Endocrine pancreatic development: impact of obesity and diet.

Autor: O'Dowd JF; Metabolic Diseases Group, Clore Laboratory, University of Buckingham Buckingham, UK., Stocker CJ

Publikováno v: Frontiers in physiology [Front Physiol] 2013 Jul 18; Vol. 4, pp. 170. Date of Electronic Publication: 2013 Jul 18 (Print Publication: 2013).

Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.

Autor: Bellahcene M; Clore Laboratory, University of Buckingham, Buckingham MK18 1EG, UK., O'Dowd JF, Wargent ET, Zaibi MS, Hislop DC, Ngala RA, Smith DM, Cawthorne MA, Stocker CJ, Arch JR

Publikováno v: The British journal of nutrition [Br J Nutr] 2013 May 28; Vol. 109 (10), pp. 1755-64. Date of Electronic Publication: 2012 Oct 31.