Zobrazeno 1 - 10
of 126
pro vyhledávání: '"O'Donoghue, AJ"'
Autor:
LaMonte, GM, Almaliti, J, Bibo-Verdugo, B, Keller, L, Zou, BY, Yang, J, Antonova-Koch, Y, Orjuela-Sanchez, P, Boyle, CA, Vigil, E, Wang, L, Goldgof, GM, Gerwick, L, O'Donoghue, AJ, Winzeler, EA, Gerwick, WH, Ottilie, S
Publikováno v:
Journal of Medicinal Chemistry
LaMonte, GM; Almaliti, J; Bibo-Verdugo, B; Keller, L; Zou, BY; Yang, J; et al.(2017). Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity. JOURNAL OF MEDICINAL CHEMISTRY, 60(15), 6721-6732. doi: 10.1021/acs.jmedchem.7b00671. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0r57k1b0
LaMonte, GM; Almaliti, J; Bibo-Verdugo, B; Keller, L; Zou, BY; Yang, J; et al.(2017). Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity. JOURNAL OF MEDICINAL CHEMISTRY, 60(15), 6721-6732. doi: 10.1021/acs.jmedchem.7b00671. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0r57k1b0
Naturally derived chemical compounds are the foundation of much of our pharmacopeia, especially in antiproliferative and anti-infective drug classes. Here, we report that a naturally derived molecule called carmaphycin B is a potent inhibitor against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f8c707eab7509a6569f1586119dd0a99
http://europepmc.org/articles/PMC5554889
http://europepmc.org/articles/PMC5554889
Akademický článek
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Autor:
Liu LJ; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States., Francisco KR; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., Sun YU; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., Serafim MSM; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.; Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG Brazil, 31270901., Amarasinghe DK; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., Teixeira TR; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., Lucero B; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States., Kronenberger T; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery (TüCAD2), Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio 70211, Finland.; Partner-site Tübingen, German Center for Infection Research (DZIF), Elfriede-Aulhorn-Str. 6, 72076 Tübingen, Germany., Elsayed W; Department of Medical Parasitology, Faculty of Medicine, Ain Shams University, Abassia, Cairo 1181, Egypt., Elwakeel H; Department of Medical Parasitology, Faculty of Medicine, Ain Shams University, Abassia, Cairo 1181, Egypt., Al-Hindy M; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., Almaliti J; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.; Department of Pharmaceutical Sciences, College of Pharmacy, University of Jordan, Amman 11942, Jordan., Gerwick WH; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., O'Donoghue AJ; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., Caffrey CR; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Publikováno v:
ACS infectious diseases [ACS Infect Dis] 2024 Dec 13; Vol. 10 (12), pp. 4182-4193. Date of Electronic Publication: 2024 Nov 26.
Autor:
Fajtova P; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague 6, Czech Republic.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA., Hurysz BM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA., Miyamoto Y; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA.; Department of Medicine, University of California San Diego, La Jolla, California, USA., Serafim MSM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA.; Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil., Jiang Z; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA., Vazquez JM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA., Trujillo DF; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA., Liu LJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA., Somani U; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA., Almaliti J; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA.; Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA., Myers SA; Division of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, California, USA., Caffrey CR; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA., Gerwick WH; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA.; Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA., McMinn DL; Kezar Life Sciences, South San Francisco, California, USA., Kirk CJ; Kezar Life Sciences, South San Francisco, California, USA., Boura E; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague 6, Czech Republic., Eckmann L; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA.; Department of Medicine, University of California San Diego, La Jolla, California, USA., O'Donoghue AJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA.
Publikováno v:
Protein science : a publication of the Protein Society [Protein Sci] 2024 Dec; Vol. 33 (12), pp. e5225.
Autor:
Quadros de Azevedo D; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG. 31270-901, Brazil., Vinícius Viera Nóia J; Departamento de Ciência da Computação, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Ribeiro YCM; Departamento de Ciência da Computação, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Alves Dos Reis R; Departamento de Ciência da Computação, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Ribeiro PHO; Departamento de Ciência da Computação, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Almeida Moura G; Departamento de Ciência da Computação, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Mendes P; Departamento de Ciência da Computação, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Barbosa de Souza AB; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG. 31270-901, Brazil., Carpini Mermejo S; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG. 31270-901, Brazil., Serafim MSM; Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil., Fernandes THM; Departamento de Matéria Prima, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Rio Grande do Sul, RS, Brazil., O'Donoghue AJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego (UCSD), San Diego, CA, US., Campos ACFA; Departamento de Ciência da Computação, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Campos SVA; Departamento de Ciência da Computação, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Gonçalves Maltarollo V; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG. 31270-901, Brazil., Oliveira Castilho R; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG. 31270-901, Brazil.
Publikováno v:
Chemistry & biodiversity [Chem Biodivers] 2024 Dec; Vol. 21 (12), pp. e202400285. Date of Electronic Publication: 2024 Nov 15.
Autor:
Rubio-Hernández M; ISTUN Institute of Tropical Health, Department of Pharmaceutical Sciences, Universidad de Navarra, 31008 Pamplona, Spain., Alcolea V; ISTUN Institute of Tropical Health, Department of Pharmaceutical Sciences, Universidad de Navarra, 31008 Pamplona, Spain., Barbosa da Silva E; Skaggs School of Pharmacy and Pharmaceutical Sciences and Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., Giardini MA; Skaggs School of Pharmacy and Pharmaceutical Sciences and Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., M Fernandes TH; Skaggs School of Pharmacy and Pharmaceutical Sciences and Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., Martínez-Sáez N; Department of Pharmaceutical Sciences, Universidad de Navarra, 31008 Pamplona, Spain., O'Donoghue AJ; Skaggs School of Pharmacy and Pharmaceutical Sciences and Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., Siqueira-Neto JL; Skaggs School of Pharmacy and Pharmaceutical Sciences and Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., Pérez-Silanes S; ISTUN Institute of Tropical Health, Department of Pharmaceutical Sciences, Universidad de Navarra, 31008 Pamplona, Spain.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2024 Nov 14; Vol. 67 (21), pp. 19038-19056. Date of Electronic Publication: 2024 Nov 01.
Autor:
Castro-Falcón G; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States., Guillén-Matus DG; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States., Da Silva EB; Skaggs School of Pharmacy and Pharmaceutical Sciences, Center for Discovery and Innovation in Parasitic Diseases, University of California San Diego, La Jolla, California 92093, United States., Guo W; Department of Chemistry, University of California Davis, Davis, California 95616, United States., Ross A; Department of Chemistry, University of California Davis, Davis, California 95616, United States., Serafim MSM; Skaggs School of Pharmacy and Pharmaceutical Sciences, Center for Discovery and Innovation in Parasitic Diseases, University of California San Diego, La Jolla, California 92093, United States., Fernandes THM; Skaggs School of Pharmacy and Pharmaceutical Sciences, Center for Discovery and Innovation in Parasitic Diseases, University of California San Diego, La Jolla, California 92093, United States., Tantillo DJ; Department of Chemistry, University of California Davis, Davis, California 95616, United States., O'Donoghue AJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, Center for Discovery and Innovation in Parasitic Diseases, University of California San Diego, La Jolla, California 92093, United States., Jensen PR; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.
Publikováno v:
BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 30. Date of Electronic Publication: 2024 Oct 30.
Autor:
Robbertse L; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice 370 05, Czech Republic., Fajtová P; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, La Jolla, California 92093-0755, United States.; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague 117 20, Czech Republic., Šnebergerová P; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice 370 05, Czech Republic.; Faculty of Science, University of South Bohemia, Ceske Budejovice 370 05, Czech Republic., Jalovecká M; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice 370 05, Czech Republic.; Faculty of Science, University of South Bohemia, Ceske Budejovice 370 05, Czech Republic., Levytska V; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice 370 05, Czech Republic., Barbosa da Silva E; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, La Jolla, California 92093-0755, United States., Sharma V; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, La Jolla, California 92093-0755, United States., Pachl P; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague 117 20, Czech Republic., Almaliti J; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, San Diego, La Jolla, California 92093-0212, United States., Al-Hindy M; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, San Diego, La Jolla, California 92093-0212, United States., Gerwick WH; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, San Diego, La Jolla, California 92093-0212, United States., Bouřa E; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague 117 20, Czech Republic., O'Donoghue AJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, La Jolla, California 92093-0755, United States., Sojka D; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice 370 05, Czech Republic.
Publikováno v:
ACS omega [ACS Omega] 2024 Oct 28; Vol. 9 (45), pp. 44989-44999. Date of Electronic Publication: 2024 Oct 28 (Print Publication: 2024).
Autor:
Bhaduri S, Braza MKE, Stanchev S, Tauber M, Al-Bawab R, Liu LJ, Trujillo DF, Solorio-Kirpichyan K, Srivastava A, Sanlley-Hernandez J, O'Donoghue AJ, Lemberg MK, Amario R, Strisovsky K, Neal SE
Publikováno v:
BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 17. Date of Electronic Publication: 2024 Oct 17.
Autor:
Silhan J; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Prague, Czech Republic., Fajtova P; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Prague, Czech Republic. fajtova@uochb.cas.cz.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA. fajtova@uochb.cas.cz., Bartosova J; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Prague, Czech Republic., Hurysz BM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Almaliti J; Department Pharmaceutical Sciences, College of Pharmacy, The University of Jordan, Amman, Jordan.; Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA., Miyamoto Y; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA., Eckmann L; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA., Gerwick WH; Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA., O'Donoghue AJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA. ajodonoghue@health.ucsd.edu.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA. ajodonoghue@health.ucsd.edu., Boura E; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Prague, Czech Republic. boura@uochb.cas.cz.
Publikováno v:
Nature communications [Nat Commun] 2024 Oct 04; Vol. 15 (1), pp. 8621. Date of Electronic Publication: 2024 Oct 04.