The rheumatoid arthritis susceptibility polymorphism PTPN22 C1858T is not associated with leflunomide response or toxicity.

Autor: Hopkins, A. M.¹, O'Doherty, C. E.¹, Foster, D. J. R.¹, Suppiah, V.¹, Upton, R. N.¹, Spargo, L. D.², Cleland, L. G.^2,3, Proudman, S. M.^2,3, Wiese, M. D.¹

Publikováno v: Journal of Clinical Pharmacy & Therapeutics. Oct2014, Vol. 39 Issue 5, p555-560. 6p.

Semiphysiologically Based Pharmacokinetic Model of Leflunomide Disposition in Rheumatoid Arthritis Patients.

Autor: Hopkins AM; University of South Australia, Australian Centre for Pharmacometrics, School of Pharmacy and Medical Sciences Adelaide, South Australia, Australia ; University of South Australia, Sansom Institute for Health Research, School of Pharmacy and Medical Sciences Adelaide, South Australia, Australia., Wiese MD; University of South Australia, Sansom Institute for Health Research, School of Pharmacy and Medical Sciences Adelaide, South Australia, Australia., Proudman SM; Royal Adelaide Hospital, Department of Rheumatology Adelaide, South Australia, Australia ; Adelaide University, Discipline of Medicine Adelaide, South Australia, Australia., O'Doherty CE; University of South Australia, Sansom Institute for Health Research, School of Pharmacy and Medical Sciences Adelaide, South Australia, Australia., Foster D; University of South Australia, Australian Centre for Pharmacometrics, School of Pharmacy and Medical Sciences Adelaide, South Australia, Australia., Upton RN; University of South Australia, Australian Centre for Pharmacometrics, School of Pharmacy and Medical Sciences Adelaide, South Australia, Australia.

Publikováno v: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2015 Jun; Vol. 4 (6), pp. 362-71. Date of Electronic Publication: 2015 Jun 15.