Zobrazeno 1 - 10
of 863
pro vyhledávání: '"O'Brien JT"'
Autor:
Croall, ID, Lohner, V, Moynihan, B, Khan, U, Hassan, A, O'Brien, JT, Morris, RG, Tozer, DJ, Cambridge, VC, Harkness, K, Werring, DJ, Blamire, AM, Ford, GA, Barrick, TR, Markus, HS
Publikováno v:
Clinical Science (London, England : 1979)
Diffusion tensor imaging (DTI) metrics such as fractional anisotropy (FA) and mean diffusivity (MD) have been proposed as clinical trial markers of cerebral small vessel disease (SVD) due to their associations with outcomes such as cognition. However
Autor:
Mak, FK, Gabel, S, Su, L, Williams, GB, Arnold, R, Passamonti, L, Vazquez Rodríguez, P, Surendranathan, A, Bevan-Jones, WR, Rowe, JB, O'Brien, JT
Publikováno v:
International Psychogeriatrics
$\textbf{BACKGROUND}$: Volumetric atrophy and microstructural alterations in diffusion tensor imaging (DTI) measures of the hippocampus have been reported in people with Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, no study
Dementia with Lewy bodies (DLB) is the underlying aetiology of 10–15% of all cases of dementia and as such is a clinically important diagnosis. In the past few years, substantial advances have been made in understanding the genetics and pathology o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854905a238e820940c0fc27a6ce09dda
https://www.repository.cam.ac.uk/handle/1810/291375
https://www.repository.cam.ac.uk/handle/1810/291375
Autor:
Stylianou, Myrto, Murphy, Nicholas, Peraza, Luis R, Graziadio, Sara, Cromarty, Ruth, Killen, Alison, O'Brien, JT, Thomas, Alan J, LeBeau, Fiona EN, Taylor, John-Paul
Objective: We investigated for quantitative EEG (QEEG) differences between Alzheimer’s disease (AD), dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) patients and healthy controls, and for QEEG signatures of cognitive fluctu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0a8480a9adc11aee0f1dadbc5b7bf5
https://www.repository.cam.ac.uk/handle/1810/277817
https://www.repository.cam.ac.uk/handle/1810/277817
Autor:
Croall, ID, Tozer, DJ, Moynihan, B, Khan, U, O'Brien, JT, Morris, RG, Cambridge, VC, Barrick, TR, Blamire, AM, Ford, GA, Markus, HS, PRESERVE Study Team
Importance: Blood pressure (BP) lowering is considered neuroprotective in patients with cerebral small vessel disease; however, more intensive regimens may increase cerebral hypoperfusion. This study examined the effect of standard vs intensive BP tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::7e73228f84bf01af448966f3ddc32aea
https://openaccess.sgul.ac.uk/id/eprint/109714/1/jamaneurology_Croall_2018_oi_170126.pdf
https://openaccess.sgul.ac.uk/id/eprint/109714/1/jamaneurology_Croall_2018_oi_170126.pdf
A significant symptom of Lewy body dementia (LBD) is slow cognitive processing or bradyphrenia. In a previous fMRI task-based study, we found slower responses in LBD, accompanied by greater deactivation in the default mode network. In this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8fa20e13195bcfb837bb1027f70d325
Autor:
Passamonti L 1, Rodríguez PV 2, Hong YT 2, Allinson KSJ 2, Bevan-Jones WR 2, Williamson D 2, Jones PS 2, Arnold R 2, Borchert RJ 2, Surendranathan A 2, Mak E 2, Su L 2, Fryer TD 2, Aigbirhio FI 2, O'Brien JT 2, Rowe JB 2.
Publikováno v:
Neurology 90 (2018): e1989–e1996. doi:10.1212/WNL.0000000000005610
info:cnr-pdr/source/autori:Passamonti L 1, Rodríguez PV 2, Hong YT 2, Allinson KSJ 2, Bevan-Jones WR 2, Williamson D 2, Jones PS 2, Arnold R 2, Borchert RJ 2, Surendranathan A 2, Mak E 2, Su L 2, Fryer TD 2, Aigbirhio FI 2, O'Brien JT 2, Rowe JB 2./titolo:[11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy./doi:10.1212%2FWNL.0000000000005610/rivista:Neurology/anno:2018/pagina_da:e1989/pagina_a:e1996/intervallo_pagine:e1989–e1996/volume:90
info:cnr-pdr/source/autori:Passamonti L 1, Rodríguez PV 2, Hong YT 2, Allinson KSJ 2, Bevan-Jones WR 2, Williamson D 2, Jones PS 2, Arnold R 2, Borchert RJ 2, Surendranathan A 2, Mak E 2, Su L 2, Fryer TD 2, Aigbirhio FI 2, O'Brien JT 2, Rowe JB 2./titolo:[11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy./doi:10.1212%2FWNL.0000000000005610/rivista:Neurology/anno:2018/pagina_da:e1989/pagina_a:e1996/intervallo_pagine:e1989–e1996/volume:90
OBJECTIVE: We tested whether in vivo neuroinflammation relates to the distinctive distributions of pathology in Alzheimer disease (AD) and progressive supranuclear palsy (PSP). METHODS: Sixteen patients with symptomatic AD (including amnestic mild co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=cnr_________::7f7f925914cc02d6ee8075a7ea4b5ff3
Background: Alzheimer’s disease (AD) is associated with atrophy in entorhinal cortex (ERC), the hippocampus, and its subfields Cornu Ammonis 1 (CA1) and subiculum, which predict conversion from Mild Cognitive Impairment (MCI) to clinical AD. The st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa5ae74d664d5afe509cf7ebc84b14e
https://www.repository.cam.ac.uk/handle/1810/269528
https://www.repository.cam.ac.uk/handle/1810/269528
Autor:
Harper, L, Bouwman, F, Burton, EJ, Barkhof, F, Scheltens, P, O'Brien, JT, Fox, NC, Ridgway, G, Schott, JM
Publikováno v:
Journal of Neurology, Neurosurgery and Psychiatry, 88(11), 908-916. BMJ Publishing Group
Harper, L, Bouwman, F, Burton, E J, Barkhof, F, Scheltens, P, O'Brien, J T, Fox, N C, Ridgway, G R & Schott, J M 2017, ' Patterns of atrophy in pathologically confirmed dementias : A voxelwise analysis ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 88, no. 11, pp. 908-916 . https://doi.org/10.1136/jnnp-2016-314978
Harper, L, Bouwman, F, Burton, E J, Barkhof, F, Scheltens, P, O'Brien, J T, Fox, N C, Ridgway, G R & Schott, J M 2017, ' Patterns of atrophy in pathologically confirmed dementias : A voxelwise analysis ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 88, no. 11, pp. 908-916 . https://doi.org/10.1136/jnnp-2016-314978
Objective Imaging is recommended to support the clinical diagnoses of dementias, yet imaging research studies rarely have pathological confirmation of disease. This study aims to characterise patterns of brain volume loss in six primary pathologies c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::38467f6b0bec419db8b329b298e9e961
https://research.vumc.nl/en/publications/d6f48c0f-460d-4981-a90f-931868709516
https://research.vumc.nl/en/publications/d6f48c0f-460d-4981-a90f-931868709516